CHOLANGIOCYTE YAP1-MEDIATED DUCTULAR REACTION EXACERBATES CIRRHOTIC PORTAL HYPERTENSION BY PROMOTING CCN1-REGULATED DISRUPTION OF HEPATIC MICROCIRCULATION (AASLD 2026) - Oct 6, 2026 - Abstract #1450; Pres time: Nov 5, 2026; 12:00 PM - 01:00 PM; Location: Convention Center: Poster Hall, Hall DE; "In addition, pharmacological inhibition of YAP1 was conducted in BDL and DDC models using Verteporfin... In conclusion, our findings demonstrate that cholangiocyte YAP1 accelerates the progression of cirrhotic PHT by facilitating DR, and further induces pathological angiogenesis and LSEC capillarization via paracrine CCN1. This study provides novel mechanistic insights and a promising targeted therapeutic strategy for the treatment of cirrhotic PHT."
Cardiovascular • Fibrosis • Gastroenterology • Hepatology • Immunology • Liver Cirrhosis • Liver Failure • Portal Hypertension • CCN1 • YAP1
|
|
Jinbo Zhao1; Zhenhao Wu1; Guqing Luo1; Mengting Li1; Hongjie Li1; Jiayun Lin1; Chihao Zhang1; Guangbo Wu1; Meng Luo1; Lei Zheng1
|