Light- and ROS-responsive nanomicelles enable targeted combination photothermal molecular therapy in melanoma cells and spheroids. (PubMed, Nanoscale) - Oct 17, 2026 - "We showed that this dual-stimuli response of light and ROS-responsive micelles (LRMs) can be leveraged to reverse the resistance of melanoma cells to a small molecule drug, trametinib...Furthermore, our results also show that LRM treatment has distinct effects in lipid remodelling and triglyceride storage in 2D cells compared to 3D spheroids, emphasizing the importance of both cellular models in understanding treatment response. Our findings will ultimately enable a new generation of stimuli-responsive nanocarriers that will have a tremendous impact on many diseases beyond cancer."
Journal • Melanoma • Oncology • Solid Tumor
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Ansuja Pulickal Mathew; Anwesha Sarkar; Irine Rose Antony; Nabila Masud; Rizia Bardhan; Surya K Mallapragada; Susheel Kumar Nethi
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