Immunofluorescence Unmasks C3-Dominant Glomerulonephritis in an Electron Microscopy (EM)-Negative Biopsy (KIDNEY WEEK 2026) - Oct 2, 2026 - Abstract #SA-PO0703; Pres time: Oct 24, 2026; 10:00 AM - 12:00 PM; Location: Exhibit Hall A, Convention Center; "Targeted complement inhibition with iptacopan (oral factor B inhibitor) was discussed as a potential option based on emerging/available trial data, pending shared decision-making.This case highlights a diagnostic pitfall in which immunofluorescence demonstrated dominant C3 deposition supporting a C3-dominant process in the C3G spectrum. Normal serum C3 complement and limited/absent capillary wall deposits on EM may delay recognition of C3-dominant disease. Dominant C3 staining on IF should prompt careful exclusion of secondary causes and consideration of complement-directed evaluation and therapy."
Biopsy • Cardiovascular • Chronic Kidney Disease • Complement-mediated Rare Disorders • Fibrosis • Glomerulonephritis • Hepatology • Hypertension • Immunology • Inflammation • Lupus Nephritis • Monoclonal Gammopathy • Nephrology • Renal Disease
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Izhar Ullah; Asmad Khan; Noman Salih; Muhammad Owais Hanif; Kazi S. Khan; Ali Arif
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