Entresto (sacubitril/valsartan) - Novartis, ROVI Pharmaceuticals Laboratories
Sex differences in leptin levels but not in the leptin response to sacubitril/valsartan in patients with heart failure with reduced ejection fraction. (PubMed, Front Cardiovasc Med) - Sep 26, 2026 - "Sex influences baseline leptin concentrations, but not the response to ARNI therapy. Further prospective studies are needed to clarify the mechanisms and clinical significance of leptin changes during sacubitril/valsartan treatment." 
Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • LEP
http://www.ncbi.nlm.nih.gov/pubmed/42787136
 
Bernhard Ohnewein; Dilvin Semo; Jürgen R Sindermann; Lukas J Motloch; Maciej Zechowicz; Michael Lichtenauer; Rudin Pistulli; Tobias Fröhling; Uta C Hoppe; Vera Paar; Zornitsa Shomanova
 
Sep 26, 2026
 
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