An orthogonal TRAP enables intersectional genetic access to activated neurons in the mouse brain (Neuroscience 2026) - Sep 27, 2026 - Abstract #PSTR290.10 / LL31; Pres time: Nov 17, 2026; 01:00 PM - 05:00 PM; Location: WCC Halls A-C; "Here we describe an approach (X-TRAP) in which the activity-dependent expression of Flp recombinase is gated by branaplam, a small molecule that triggers splicing of the X-ON switch...We apply this strategy to generate intersectional maps of neuronal populations activated by GLP-1-induced satiety and nausea, revealing overlapping and distinct subpopulations across the brain that contribute to these responses. This approach for intersectional, activity-dependent genetic labeling should improve our ability to identify neural circuits underlying behavior with greater specificity."
Preclinical • CNS Disorders
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N. CHATZIRIS1; B. JARVIE1,3; C. LIU3; Z. KNIGHT1,2,3
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