Endothelin Receptor A Antagonism Attenuates Hypertension in Aged Female GPER1 Knockout Mice (KIDNEY WEEK 2026) - Oct 2, 2026 - Abstract #FR-PO0980; Pres time: Oct 23, 2026; 10:00 AM - 12:00 PM; Location: Exhibit Hall A, Convention Center; "Aortic ET A and ET B mRNA expression were assessed in 20-22 month-old GPER1 WT and KO female mice (n=4-7/group).Given the established vasoconstrictive role of ET A , atrasentan (an ET A antagonist) was used to determine the contribution of ET A to hypertension in GPER1 KO mice...Conclusion Our data suggest that ET A contributes to the increase in BP evident in aged female mice lacking GPER1, possibly via increased vasoconstriction. These findings may provide insight regarding potential therapeutic targets for postmenopausal hypertension."
Preclinical • Cardiovascular • Hypertension • EDN1 • GPER1
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Ravneet Singh; Ian Tweed Ross; Dennis P. Buehler; Eman Y. Gohar
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