Identification of Plasma Protein Biomarkers for Early-Onset Stroke through Mendelian Randomization. (PubMed, medRxiv) - Sep 25, 2026 - "Drug-target mapping highlighted Factor XI as a leading therapeutic target, supported by existing inhibitors (e.g., abelacimab, milvexian). These findings highlight biologically plausible biomarkers and prioritize druggable targets, particularly Factor XI, for prevention of EOS and demonstrate the value of proteogenomic approaches for uncovering disease mechanisms and informing precision prevention strategies. Proteome-wide MR of 1,041 plasma proteins identified causal drivers of early-onset stroke, with strongest effects in coagulation (ABO, F7, F11) and immune-inflammatory pathways."
Biomarker • Journal • Cardiovascular • Venous Thromboembolism • EHBP1 • VAMP8
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Anna L Huynh; Brady J Gaynor; Braxton D Mitchell; Christina Jern; Guillaume Paré; Huichun Xu; John W Cole; Michael Chong; Patrick F McArdle; Steven J Kittner; Tara M Stanne
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