Optimizing the Therapeutic Index: Sequential Intraarterial-Intravenous PRRT with Personalized Volumetric-Adjusted Dosing. (PubMed, J Nucl Med) - Sep 25, 2026 - " The sequential administration of intraarterial followed by intravenous 177Lu-DOTATATE is a feasible and safe therapeutic strategy for liver-dominant metastatic NETs. The use of a personalized, volumetric-based approach provided higher uptake and absorbed doses in hepatic metastases, with high objective response rates and effectively maintained systemic coverage."
Journal • Hepatocellular Cancer • Hepatology • Neuroendocrine Tumor • Oncology • Pancreatic Cancer • Solid Tumor • SSTR
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Adrian Gonzalez-Aguirre; Audrey Mauguen; Bae Chu; Diane Reidy; Etay Ziv; Heiko Schöder; Jonathan Kuten; Joseph A O'Donoghue; Lisa Bodei; Nitya Raj; Pat Zanzonico
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