Ferroptosis at the Metabolic-Immune Interface in Metastatic Castration-Resistant Prostate Cancer: Mechanistic Evidence, Translational Gaps, and Combination Strategies. (PubMed, Ann Surg Oncol) - Sep 24, 2026 - "AR-linked lipid and redox programs influence ferroptosis susceptibility in prostate cancer. Translation requires direct ferroptosis causality, tumor-selective delivery, preservation of immune-cell fitness, clinically relevant models, and orthogonal pharmacodynamic assessment. Clinical benefit from ferroptosis-based combinations with checkpoint inhibitors or 177Lu-PSMA radioligand therapy has not been demonstrated."
Journal • Review • Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • ACSL4 • AR • CGAS • DECR1 • GPX4 • SLC7A11 • STING
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Chih-Jen Wang; Chun-Chi Chen; Hung-Yu Lin
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