Simple LC-MS/MS Method for Ruxolitinib in Human Plasma and Its Clinical Application in Pediatric and Adult Patients. (PubMed, Biol Pharm Bull) - Sep 24, 2026 - "Notably, an intraindividual comparison in one adult case revealed that posaconazole co-administration increased the trough concentration by approximately 4-fold and the area under the plasma concentration-time curve by approximately 2-fold, compared with the period without azoles. In conclusion, we established a validated LC-MS/MS method that was applicable to the measurement of ruxolitinib concentrations in pediatric and adult patients in this single-center study. This method may contribute to the accumulation of pharmacokinetic data for future evaluation of TDM strategies."
Journal • Graft versus Host Disease • Hemophagocytic lymphohistiocytosis • Immunology • Pediatrics • Rare Diseases
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Atsushi Manabe; Atsushi Yamaguchi; Fuyo Takeda; Keisuke Kagami; Masahiro Ueki; Mitsuru Sugawara; Shinsuke Hirabayashi; Shunsuke Nashimoto; Souichi Shiratori; Takanori Teshima; Yoh Takekuma; Yuki Tazawa
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