The hemodynamic effects of sacubitril/valsartan in the first 24 h of initiation in pediatric cardiac intensive care unit patients: insights using high-fidelity data. (PubMed, Pediatr Cardiol) - Sep 25, 2026 - "Linear mixed effects models were used to estimate post-initiation trends in absolute units from 2 to 24 h, accounting for repeated measures within patients and adjusting for age, ventricular assist device status, milrinone exposure, and circulatory physiology. Sacubitril/valsartan initiation in critically ill children is associated with coordinated changes in arterial, venous, and tissue-level physiology consistent with improved systemic oxygen delivery. The response appears continuous, with variability in magnitude across patients rather than discrete phenotypes."
Journal • Critical care • Pediatrics
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Adam Morrison; Agnes Szarek; Erika Mejia; Krysta Walter; Oscar Dominguez; Rohit S Loomba; Wesam Sourour
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