Mitochondrial DNA released by Biliary Epithelial Cells enhances inflammation in Biliary Atresia through the cGAS-STING-NF-κB pathway. (PubMed, Cell Mol Gastroenterol Hepatol) - Sep 25, 2026 - "mtDNA leakage activates the cGAS-STING-NF-κB pathway in BECs, driving a CXCL10/IL-32-dominant inflammatory response. CoQ10 mitigates this process and injury, supporting cGAS-STING modulation and mitochondrial stabilization as promising therapeutic strategies for BA."
Journal • Fibrosis • Hepatology • Immunology • Inflammation • Liver Failure • Rotavirus Infections • CGAS • CK19 • CXCL10 • IL32 • KRT19 • STING
|
|
Changgui Lu; Hua Xie; Ruyi Zhang; Weibing Tang; Xiaofeng Lv; Yufei Zhu; Zequan Ding; Zhengchen Lu; Zhongxian Zhu; Ziqi Tu
|