Monoallelic Apolipoprotein 1 Variants in Living Kidney Donors Are Associated with Impaired Long-Term Graft Survival: Results from the Brazilian Investigation on Donor Genetic Evaluations (KIDNEY WEEK 2026) - Oct 2, 2026 - Abstract #FR-PO1137; Pres time: Oct 23, 2026; 10:00 AM - 12:00 PM; Location: Exhibit Hall A, Convention Center; "Induction therapy with thymoglobulin or basiliximab was administered in 31.9% of recipients. Maintenance immunosuppression predominantly consisted of a calcineurin inhibitor combined with azathioprine (69.8%), with no significant differences between groups...Conclusion In this Brazilian cohort of living donor kidney transplantation, APOL1 risk variants were independently associated with inferior long-term graft survival. Notably, even the presence of a single APOL1 risk allele was associated with a significantly increased risk of death-uncensored graft loss."
Transplantation
|
|
Melissa Gaspar Tavares; Luisa Queiroga Ferreira; Guilherme De Sousa Ferreira; Leonardo Moura Godoi; Marina Oliveira Melo Soares; Rhaon Pietro Santos Finamor; Roberta Oliveira Alves Lima; Helio Tedesco-Silva; Renato Demarchi Foresto; Jose Medina-Pestana; Lucio Roberto Requiao-Moura
|