Accounting for partial volume effects makes baseline tumoral SUVmean from 177 Lu-PSMA SPECT prognostically comparable to 68 Ga-PSMA PET (EANM 2026) - Sep 29, 2026 - Abstract #OP-681; Pres time: Oct 20, 2026; 03:00 PM - 04:30 PM; Location: Hall B; "Materials and Patients with metastatic castration-resistant prostate cancer treated with [177Lu]Lu-PSMA-617 who underwent pre-therapeutic [68Ga]Ga-PSMA-11 PET and quantitative whole-body 360° CZT SPECT acquired 24h after treatment cycles were retrospectively included... Partial volume effects markedly reduce the prognostic value of baseline tumoral SUVmean measured on 177Lu-PSMA whole-body 360° CZT-SPECT. A simple phantom-based recovery coefficient adjustment substantially improves its prognostic performance, bringing it to a level comparable to that obtained with pre-therapeutic PSMA PET. These results suggest that the tumoral SUVmean determined by SPECT after the first [177Lu]Lu-PSMA injection may provide clinically relevant prognostic information when partial volume effects are accounted for."
Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor
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S. Heyer 1; C. Boursier-Joppin 1; A. Zouaoui 2; S. Melki 2; P. Olivier 1; M. Claudin 2; P. Marie 1; L. Imbert 1
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