RIBOCICLIB INDUCED HEPATOTOXICITY: INSIGHTS INTO THE MECHANISM OF LIVER INJURY, CLINICAL COURSE, AND MANAGEMENT (AASLD 2026) - Oct 6, 2026 - Abstract #3344; Pres time: Nov 7, 2026; 01:00 PM - 02:00 PM; Location: Convention Center: Poster Hall, Hall DE; "Palbociclib was held and liver enzymes normalized. Prednisone was started in all our patients resulting in rapid improvement and normalization of liver enzymes... We believe that ribociclib causes indirect hepatotoxicity, mechanistically like immunotherapy induced hepatitis (ICH) as seen with immune check point inhibitors. Hepatotoxicity from ribociclib, like ICH, is dose-independent with variable latency period. Liver biopsy showed features commonly seen in ICH."
Clinical • IO biomarker • Addiction (Opioid and Alcohol) • Breast Cancer • Hepatology • HER2 Breast Cancer • HER2 Negative Breast Cancer • HER2 Positive Breast Cancer • Hormone Receptor Breast Cancer • Hormone Receptor Positive Breast Cancer • Immunology • Infectious Disease • Liver Failure • Solid Tumor • HER-2
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Shelbie Manna1; Shaun Li1; Arvind Murali1
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