FDX1 is associated with CALR abundance and JAK-STAT-related inflammatory signaling in myeloproliferative neoplasms. (PubMed, Front Oncol) - Oct 14, 2026 - "Functionally, FDX1 knockdown reduced total CALR abundance, STAT5 phosphorylation, cytokine release, sensitivity to copper-dependent cytotoxicity, and proliferation, whereas FDX1 overexpression showed the reciprocal pattern and was partly counteracted by ruxolitinib. These findings support an association between FDX1 perturbation, total CALR abundance, STAT5-associated signaling, and inflammatory output in MPN, but do not establish direct regulation of mutant CALR or mutant CALR-MPL signaling."
CALR • Journal • Essential Thrombocythemia • Fibrosis • Hematological Disorders • Myelofibrosis • Myeloproliferative Neoplasm • Oncology • Polycythemia Vera • Thrombocytosis • CALR • FDX1 • IL6 • STAT5 • TNFA
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Diernu Simayi; Diyaer Abuduaini; Mihelayi Maimaiti; Yinglan Feng; Yixia Wang
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