Poster Rounds with the Professor: Efficacy of Avutometinib and Defactinib vs Conventional Care in Low-Grade Serous Ovarian Cancer (LGSOC): An External Control Arm Analysis (Businesswire) - Oct 2, 2026 - "The external control arm analysis compared outcomes among patients treated with avutometinib plus defactinib in RAMP 201 with a matched and reweighted cohort treated with conventional care, chemotherapy or anti-estrogen therapy, from the GOG 281 trial. Among patients with KRAS-mutated LGSOC, weighted ORR was 38.7% with avutometinib plus defactinib versus 0% with conventional care and median weighted PFS was 22.1 months versus 6.5 months, respectively. Among patients with KRAS wild-type LGSOC, weighted ORR was 22.7% with avutometinib plus defactinib versus 7.9% with conventional care and median weighted PFS was 11.3 months versus 7.7 months, respectively. 'Patients whose tumors are wild-type for KRAS, NRAS, and/or BRAF have typically experienced response rates under 10% with trametinib, chemotherapy or endocrine therapy'..."
P2 data • Low Grade Serous Ovarian Cancer
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