Genetic evidence and multi-omics characterization of DEHP-relevant detoxification and metabolic heterogeneity in hepatocellular carcinoma. (PubMed, Front Toxicol) - Oct 15, 2026 - "LINCS-based screening and molecular docking prioritized PD-0325901, trametinib, and regorafenib, but these predictions did not demonstrate binding or efficacy, and the compounds were not tested experimentally. DPTS defines a DEHP-relevant, detoxification-suppressed HCC molecular phenotype rather than an exposure-defined or DEHP-induced subtype. These findings provide a bounded framework for future mechanistic validation of metabolic vulnerability in HCC."
Heterogeneity • Journal • Hepatocellular Cancer • Oncology • Solid Tumor • ALDH2 • EHHADH
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Guoqing Zhang; Letian Ren; Wence Zhou; Zeyang Fan
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