Corneal Stiffening and Hyperosmolar Stress Associate With YAP1/TAZ Activation and Ocular Surface Inflammation in Dry Eye Disease. (PubMed, Transl Vis Sci Technol) - Oct 14, 2026 - "A desiccating stress (DS) mouse model was established using low humidity and scopolamine...DS mice received topical verteporfin (VP) or vehicle control...YAP1/TEAD inhibition in DS mice ameliorates corneal injury and inflammatory signaling, supporting functional involvement. Pharmacologic modulation of YAP1/TEAD signaling may represent a therapeutic strategy for inflammation-dominant DED."
Journal • Corneal Abrasion • Dry Eye Disease • Inflammation • Ocular Inflammation • Ophthalmology • CTGF • IL1B • IL6 • WWTR1 • YAP1
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Bin Lu; Haoran Chen; Huijuan Chen; Jiaxin Han; Kexin Li; Liang Hu; Qianwen Gong; Xiujuan Lv; Yang Lu; Yuanyuan Liu; Yuzhou Wang
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