Public availability of trial-design and clinical-context information in contemporary lipoprotein(a)-targeted cardiovascular trials: A cross-sectional meta-research study. (PubMed, Am Heart J Plus) - Oct 6, 2026 - "Other elements were identifiable less consistently: Lp(a) unit (13/14), background lipid-lowering therapy (9/14), numeric Lp(a) threshold (8/14), PCSK9/inclisiran handling (8/14), demographic information (8/14), CKD/eGFR criteria (6/14), heart failure criteria (6/14), diabetes criteria (5/14), and LDL-C context (3/14). Public availability varied across contemporary Lp(a)-targeted trials at the data lock, particularly for registry-only programs. These findings describe fixed-date public retrievability and should not be interpreted as protocol deficiency, registry noncompliance, trial quality, efficacy, safety, or regulatory readiness."
Journal • Cardiovascular • Congestive Heart Failure • Diabetes • Heart Failure • Metabolic Disorders
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Daniel Yow; Joyce Gu; Lucy Zheng; Samuel Tan
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