Cardiac Resynchronization as an Enabler of ARNI Efficacy: Insights From a Real-World Cohort. (PubMed, J Arrhythm) - Oct 5, 2026 - "Sacubitril/valsartan (ARNI) improves outcomes in heart failure with reduced ejection fraction (HFrEF)...In this real-world CRT cohort, ARNI therapy enhanced reverse remodeling and reduced subclinical congestion events detected by remote monitoring. These findings support a synergistic interaction between CRT and ARNI, where resynchronization provides the substrate for pharmacological efficacy."
Journal • Real-world evidence • Cardiovascular • Congestive Heart Failure • Heart Failure
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Alberto Palazzuoli; Amato Santoro; Antonio Pagliaro; Benedetta Maria Natali; Claudia Baiocchi; Francesco Morrone; Laura Spaccaterra; Massimo Fineschi; Maurizio Collantoni; Niccolò Manetti; Stefano Lunghetti
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