SIRT7 upregulation protects against TKI-induced cardiotoxicity by inhibiting MCU-mediated mitochondrial calcium overload. (PubMed, Front Pharmacol) - Oct 4, 2026 - "AC16 cells were treated for 72 h with three TKIs: sunitinib (4.11 µM, IC30), trametinib (12.21 µM, IC30), and imatinib (21.84 µM, IC30). In hiPSC-CMs, SIRT7 overexpression reduced mitochondrial Ca2+ overload and prevented TKI-induced contraction inhibition. SIRT7 upregulation protects against TKI-induced cardiotoxicity by inhibiting MCU-mediated mitochondrial calcium overload."
Journal • Cardiovascular • Oncology • SIRT7 • TNNI3
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Congxin Li; Meiling Gao; Suhua Qiu; Wei Yan; Wenting Wu; Xianying Wang; Yanfang Xu; Zhe Wang; Zhihan Zhang; Zhiling Cheng
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