Loss of UBE3C-mediated PIM2 ubiquitination drives Helicobacter pylori-induced gastritis via JAK2/STAT3 activation. (PubMed, Mol Cell Biochem) - Oct 14, 2026 - "Combined treatment with the JAK1/2 inhibitor Ruxolitinib further potentiated the anti-inflammatory effects of PIM2 knockdown in H. pylori-infected GES-1 cells and mouse gastric tissues. This study revealed a novel mechanism by which H. pylori promoted gastritis through downregulation of UBE3C, impairment of PIM2 ubiquitination, and activation of the JAK2/STAT3 pathway. The dual benefits of PIM2 knockdown, suppressing inflammation while promoting bacterial clearance, positioned PIM2 as a potential therapeutic target for H. pylori-associated gastritis."
Journal • Gastrointestinal Disorder • Hematological Malignancies • Infectious Disease • Leukemia • Oncology • Targeted Protein Degradation • JAK2 • STAT3
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Juan Zheng; Xiaoping Zhu; Yan Xiong; Yanhuan Tang
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