Type I autoimmunity in chronic spontaneous urticaria: Evidence, limits, and endotype overlap. (PubMed, J Allergy Clin Immunol) - Oct 14, 2026 - "However, total IgE level, atopy, allergic disease, and timing of the response to omalizumab are not diagnostic of this mechanism...Progress will require harmonized functional assays; skin, mast cell, and basophil readouts, as well as longitudinal treatment studies. The central question is when an IgE autoantibody is only a passenger, when it is a partner, and when it is the driver of the wheal."
Journal • Review • Allergy • Chronic Spontaneous Urticaria • Dermatology • Immunology • Urticaria
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Clive E H Grattan; George N Konstantinou
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