A Population-Based Pharmacokinetic Model of [ 177 Lu]Lu-PSMA-617 for Predicting Organ and Tumor Biodistribution in Prostate Cancer Patients (EANM 2026) - Sep 29, 2026 - Abstract #EP-1242; "This population PK modeling predicts distribution of [¹⁷⁷Lu]Lu-PSMA-617 and its inter-individual variability in prostate cancer patients. Tumor burden was identified as a key driver of uptake kinetics, highlighting its relevance for treatment personalization. The proposed framework supports population-based prediction of radioligand distribution and may facilitate improved dosimetry and therapy optimization."
Clinical • PK/PD data • Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Oncology • Prostate Cancer • Salivary Gland Cancer • Solid Tumor
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V. Spielmann 1; D. Kupitz 2; W. Li 1; M. Kreißl 2, 3
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