Clinical outcomes of sacubitril/valsartan in patients with mildly reduced or preserved ejection fraction and acute heart failure: a multi-institutional study. (PubMed, Ann Med) - Oct 13, 2026 - "In this multi-institutional real-world cohort of patients hospitalized for acute HF with left ventricular ejection fraction (LVEF) >40%, in-hospital initiation of sacubitril/valsartan was not associated with lower risks of HF rehospitalization or CV death compared with ARB therapy, despite greater NT-proBNP reduction in a biomarker subcohort. Limited sample size precludes definitive conclusions regarding therapeutic equivalence."
Clinical • Clinical data • Journal • Retrospective data • Cardiovascular • Chronic Kidney Disease • Heart Failure • Nephrology • Renal Disease
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Birdie Huang; Chieh-Yu Chang; Chun-Chi Chen; Dong-Yi Chen; I-Chang Hsieh; Ming-Jer Hsieh; Ming-Lung Tsai; Ming-Shien Wen; Pao-Hsien Chu; Shao-Wei Chen; Tien-Hsing Chen
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