muvalaplin (LY3473329) - Eli Lilly
pelacarsen (AKCEA-APO(a)-LRx) - Novartis
zerlasiran (SLN360) - Silence Therap
olpasiran (AMG 890) - Amgen
lepodisiran (LY3819469) - Eli Lilly
Efficacy and tolerability of targeted lipoprotein(a)-lowering therapies: A systematic review. (PubMed, J Clin Lipidol) - Oct 7, 2026 - "Emerging Lp(a)-targeted therapies achieve significant reductions in circulating Lp(a) concentrations and represent a promising strategy for addressing residual cardiovascular risk associated with elevated Lp(a). Ongoing large-scale cardiovascular outcome trials will determine whether pharmacologic lowering of Lp(a) translates into reductions in cardiovascular events." 
Journal • Review • Atherosclerosis • Cardiovascular • Coronary Artery Disease • Myocardial Infarction
http://www.ncbi.nlm.nih.gov/pubmed/42838767
 
Anurag Mehta; Dave L Dixon; Fadi N Salloum; Kayla Harley; Mathew Ambrosio; Matthew K Campbell; Nicholas Ws Chew; Pamela L Alebna; Yip Han Chin
 
Oct 7, 2026
 
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