Impact of Deep Learning Denoising on Time Activity Curves and Dosimetric Accuracy in Preclinical Theranostic SPECT (EANM 2026) - Sep 29, 2026 - Abstract #EP-1111; "Materials and Tumor-bearing mice and healthy controls were injected with 177Lu-FAPI-46 (n=19) or 161Tb-FAPI-46 (n=17)... A DL-DN model trained on diagnostic micro-SPECT successfully transfers to theranostic 177Lu and 161Tb images, offering substantial voxel-level noise suppression without compromising inter-subject variability. This makes denoising highly promising for voxel-based dosimetry. However, the systematic downward bias in TIA warrants caution in dosimetric applications."
Preclinical
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E. Taragola 1; A. Meskens 1; F. M. Muller 1, 2; S. Neyt 1; M. Abi Akl 1; F. De Vos 1; S. Vandenberghe 1; C. Vanhove 1
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