The influence of anti-CD20-directed B cell depletion across different agents on Epstein-Barr virus-specific humoral and cellular immunity in patients with multiple sclerosis. (PubMed, J Neuroinflammation) - Sep 30, 2026 - "Unlike in treatment-naïve pwMS, BCDT is associated with selectively lower EBV-specific T-cell frequencies while EBV-specific and polyclonal T-cell functionality was largely preserved. In contrast, EBV-specific antibody levels were persistently higher despite treatment. Given the remarkably high clinical efficacy of BCDT in this cohort, the findings support a prominent role of EBV-specific cellular immunity in ongoing MS pathophysiology and suggest that reduced EBV-reactive T-cell responses may contribute to this potency. Differences between BCDT agents warrant further investigation."
Journal • CNS Disorders • Epstein-Barr Virus Infections • Multiple Sclerosis • CD4 • CD8 • IFNG • IL2
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Beatrice Tocariu-Krick; Celina Kron; Chiara Huber; Eszter Németh; Gabriel Gonzalez-Escamilla; Jakob Stögbauer; Katharina Schwartz; Martina Sester; Mathias Fousse; Niklas Saenz Kämpfer; Olaf Stüve; Rebecca Urschel; Saskia Bronder; Sergiu Groppa; Sven G Meuth; Tina Schmidt; Wenlin Hao
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