SSTR2 receptor states and cellular metabolism modulate 177Lu-DOTATATE binding affinity. (PubMed, EANM Innov) - Oct 2, 2026 - "By employing cell-based real-time binding assays, we were able de-convolute the contribution of distinct receptor states to 177Lu-DOTATATE affinity and retention and study the impact of internalization and recycling dynamics. Improved understanding of ligand/drug-GPCR interactions and how these are impacted by the cellular environment and metabolism can be used to optimize existing and new therapeutic approaches."
Journal • Endocrine Cancer • Oncology • Solid Tumor • SSTR • SSTR2
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Julie Nonnekens; Pleun A M Engbers; Sara Lundsten Salomonsson; Sina Bondza
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