Age-associated Autoimmunity Driven by T cell Immunosenescence. (PubMed, bioRxiv) - Oct 2, 2026 - "Notably, a senescent cell-clearing senolytic agent (fisetin) decreased the pathogenic capacity of CD4+ T cells, and a SASP-suppressing senomorphic therapy (ruxolitinib) protected mice against autoimmune demyelination. Together, these findings delineate a key role for age-associated senescent CD4+ T cells in driving age-associated autoimmunity."
Journal • Diabetes • Immunology • Metabolic Disorders • Pain • Type 1 Diabetes Mellitus • CD4 • CDKN1A • TNFSF8
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Anthony J Covarrubias; Caitlyn L H Pham; Christian Bustillos; Christopher Fu; Ethan C McCarthy; Faranak Fattahi; Isabela Salazar; Ivan A Salladay-Perez; Jason K Whitmire; Jocelyn Weng; Madison F Bang; Maryamsadat Seyedsadr; Maureen A Su; Mehdi Bouhaddou; Melissa G Lechner; Perry Shieh; Sophie Blanc
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