An age-preserving neuronal iSpheroid platform for modeling human aging and Alzheimer's disease. (PubMed, bioRxiv) - Oct 11, 2026 - "Oxaliplatin shifted AD iSpheroids toward oxidative metabolism, whereas a multi-compound screen identified trametinib as a modulator of inflammatory and age-associated programs. - Direct conversion generates age-preserving, functional human neuronal iSpheroids.- iSpheroids recapitulate molecular and pathological hallmarks of AD.- Multi-omics distinguishes physiological neuronal aging from AD.- Pharmacological screening identifies reversible metabolic and inflammatory phenotypes."
Journal • Alzheimer's Disease • CNS Disorders • Metabolic Disorders
|
|
; Brian Kirk; Chynna Bowman; Daniela Boassa; Elise MacDonald; Fred H Gage; George J Murphy; Jeffrey R Jones; Jerome Mertens; Joseph R Herdy; Julio Martinez-Trujillo; Kazuori Yoshikiyo; Kotaro Oiwa; Lisa Mitchell; Lukasz Jaremko; Marjan Mahmoudi; Meiyan Wang; Melissa Hernandez; Michael S Cuoco; Nicholas Skvir; Raffaella Lucciola; Ravi Agarwal; Samhan Alsolami; Samuel Cranston; Thais Sarraf Sabedot; Upendra Singh
|