Senescent tumor cell membrane-based "time engine" nanosystem amplifies endoplasmic reticulum targeting for metastasis blockade. (PubMed, Sci Adv) - Oct 10, 2026 - "Herein, we design a "time engine" nanosystem for amplified ER targeting: Firstly, ribociclib is encapsulated into SNP (R@SNP) to induce tumor cell senescence; then, SNP loaded with brefeldin A (B@SNP) is used to trigger ER stress. By sequential therapy, R@SNP disrupts the cytoskeleton of 4T1 tumor cells to eliminate ER-targeting barriers and remodels the tumor immune microenvironment; B@SNP boosts ER-targeting efficiency and triggers intense ER stress. Collectively, such time engine nanosystem achieves excellent ER accumulation and antimetastatic efficacy in 4T1 tumor-bearing mice, providing an innovative perspective for subcellular delivery and tumor treatment."
Journal • Oncology
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Fengzhi Zhang; Jiahui Wu; Jing Tao; Jinxia Kong; Lian Li; Liyun Xing; Yuan Huang; Yuzhen Guo; Zhou Zhou
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