Inhibition of LDHA Upregulates PSMA Protein Expression and Sensitizes PSMA-RLT in Prostate Cancer (EANM 2026) - Sep 29, 2026 - Abstract #EP-0916; "Therapeutic efficacy was compared between 177LuPSMA617 monotherapy and the combination with OXAMATE... This study reveals for the first time that LDHA negatively regulates PSMA through direct binding. Inhibiting LDHA upregulates PSMA and enhances ligand retention, thereby improving the efficacy of PSMAtargeted therapy. This strategy offers a new approach to enhance treatment response in CRPC patients."
Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • FOLH1 • LDHA
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