GLP-1/glucagon dual agonist reduces weight across three dosing regimens in obesity (Healio) - Nov 18, 2025 - "At 32 weeks, the reduction in body weight with mazdutide was 7.3% with a 6 mg dose, 15.6% with the 10 mg dose and 18.1% with the 16 mg dose vs. a 0.9% weight reduction with placebo....At 48 weeks, 52% of the 16 mg mazdutide group and 49% of the 10 mg group lost at least 20% of their body weight compared with 3% of the placebo group...At 48 weeks, waist circumference decreased by 11 cm in the 6 mg mazdutide group, 16.7 cm in the 10 mg group and 16.6 cm with the 16 mg dose vs. a 1.2 cm reduction with placebo....All three mazdutide groups had significant decreases in HbA1c, fasting glucose and fasting insulin at 48 weeks compared with placebo."
P2 data • Obesity
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