ampicillin/sulbactam / Generic mfg. - LARVOL DELTA

The effectiveness and safety between colistin-based and high-dose ampicillin/sulbactam-based combination antibiotic therapy for hospital-acquired pneumonia caused by Carbapenem-resistant Acinetobacter baumannii pneumonia (ERS 2025) - No abstract available

Clinical • Infectious Disease • Pneumonia • Respiratory Diseases

Effects of Different Antibiotic Regimens in Preterm Premature Rupture of Membranes (clinicaltrials.gov) - P=N/A | N=40 | Completed | Sponsor: Yuzuncu Yıl University

New trial

Overcoming phage resistance: efficacy of sequential phage-colistin therapy against carbapenem-resistant Acinetobacter baumannii. (PubMed, Microbiol Spectr) - "PAS was assessed in vitro using meropenem, colistin, tigecycline, rifampin, and ampicillin/sulbactam. Our findings provide valuable translational insights, supporting the potential application of phage therapy in human medicine. By addressing the critical issue of phage resistance, this study advances the development of sustainable bacteriophage-antibiotic treatment regimens against CRAB and other drug-resistant pathogens."

Journal • Infectious Disease

Liver Abscess and ARDS in a Healthy Young Male Following Routine Dental Cleaning: An Uncommon Sequelae of Group G Streptococcal bacteremia (ACG 2025) - "He was started on IV piperacillin-tazobactam and underwent IR-guided abscess drainage...Post-extubation, antibiotics were narrowed to ampicillin-sulbactam...He improved with ertapenem and was discharged with outpatient follow-up. PLA in healthy individuals is rare...Early recognition and multidisciplinary care are critical to favorable outcomes as complications of PLA, such as ARDS, can occur due to systemic inflammatory response. This case adds to the limited literature on GGS-induced liver abscess in healthy individuals, highlighting the systemic implications of what may appear to be a routine outpatient procedure.Figure: CT abdomen with contrast shows a 6.1 cm * 6.2 cm * 6.4 cm right hepatic lobe fluid collection"

Clinical • Acute Respiratory Distress Syndrome • Hepatology • Immunology • Infectious Disease • Inflammation • Mood Disorders • Respiratory Diseases • Systemic Inflammatory Response Syndrome

A Rare Complication of Hepatic Cysts in Advanced Autosomal Dominant Polycystic Kidney and Liver Disease (ACG 2025) - "Patient was empirically started on intravenous meropenem and later de-escalated to ampicillin-sulbactam...The patient improved clinically and was discharged on oral amoxicillin-clavulanate, with plans for outpatient dialysis, and outpatient kidney and liver transplant evaluation. This case highlights a rare, but serious complication of ADPKD/PLD: hepatic cyst infection leading to sepsis and AKI on CKD...Figure: Figure 1: Non-contrast CT Imaging of the Abdomen Showing Extensive Polycystic Changes in Both Kidneys and Liver, Consistent with Advanced Autosomal Dominant Polycystic Kidney and Liver Disease. Liver cyst with measurement (13.8 cm x 11 cm) indicates the hepatic cyst that was drained percutaneously, with 1000 mL serous drainage output."

Metastases • Autosomal Dominant Polycystic Kidney Disease • Chronic Kidney Disease • Genetic Disorders • Hepatology • Infectious Disease • Nephrology • Polycystic Kidney Disease • Renal Disease • Septic Shock

A Rare Case of Septic Shock Secondary to Bacteroides fragilis Empyema in the Setting of Ruptured Liver Abscess (ACG 2025) - "Initially, the patient received broad-spectrum IV antibiotics, including piperacillin-tazobactam, which was later narrowed to ampicillin-sulbactam based on culture sensitivities. underscores the critical nature of this infection. Timely diagnosis through imaging and microbiological analysis, coupled with antibiotics and surgical drainage, is crucial for successful management"

Clinical • Addiction (Opioid and Alcohol) • Cardiovascular • Diabetes • Hepatology • Hypertension • Infectious Disease • Metabolic Disorders • Respiratory Diseases • Septic Shock • Type 2 Diabetes Mellitus

A Case Report of Clostridium perfringens Bacteremia Following Colorectal Cancer Resection (ACG 2025) - "Infectious Disease was consulted and recommended treatment with ampicillin-sulbactam with the transition to oral amoxicillin-clavulanate upon discharge. CT abdomen and pelvis showing colitis in the sigmoid colon (red arrows).Figure: Figure 2. CT abdomen and pelvis showing colitis in the descending colon (red arrows) and colonic hyperemia (blue arrow)."

Case report • Clinical • Biliary Cancer • Colon Cancer • Colorectal Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Genito-urinary Cancer • Immunology • Infectious Disease • Nephrology • Neutropenia • Oncology • Prostate Cancer • Renal Disease • Solid Tumor

A Rare Long Term Complication (ACG 2025) - "The patient was started on intravenous ampicillin-sulbactam 3 grams every 6 hours...A high index of suspicion and early treatment improve outcomes. Management should be individualized based on timing, location, and cause, with supportive measures (e.g., wound care, adequate feeding) as important as surgical repair.Figure: Figure 1Figure: Figure 2"

Cough • Gastrointestinal Disorder • Otorhinolaryngology • Respiratory Diseases

A Rare Case of Pylephlebitis Arising From Sigmoid Diverticulitis (ACG 2025) - "Patient was treated with ampicillin-sulbactam and discharged on amoxicillin-clavulanate. Thrombophlebitis was thought to be provoked, heparin drip was initiated, and transitioned to Eliquis with plans for 3 months of therapy...It was seen that these individuals did not have an underlying hypercoagulable state or mesenteric vein involvement. Overall, the decision to use anticoagulation should be individualized to patient risk factors and comorbidities."

Clinical • Cardiovascular • Fibrosis • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Hypertension • Immunology • Infectious Disease • Pancreatitis • Portal Hypertension • Thrombosis

MANAGEMENT OF SEPTIC SHOCK IN PNEUMONIA ASPIRATION OF STROKE PATIENT: A CASE REPORT (MTS 2025) - "Pneumonia treatment began with Ampicillin-Sulbactam and Levofloxacin...He was diagnosed with septic shock and managed with fluid resuscitation, antibiotics escalation, IV vasopressors, and hydrocortisone... Stroke significantly raises pneumonia risk, which can escalate into septic shock. Early diagnosis and aggressive treatment are essential to reduce mortality in such cases."

Case report • Clinical • Cardiovascular • CNS Disorders • Gastrointestinal Disorder • Hypotension • Infectious Disease • Metabolic Disorders • Pneumonia • Respiratory Diseases • Septic Shock

The effect of intraoperative excessive bleeding on the pharmacokinetics of ampicillin and sulbactam in recipients of living donor liver transplantation in Japan. (PubMed, JAC Antimicrob Resist) - "Guidelines recommend redosing with intravenous prophylactic antibiotics when excessive bleeding exceeds 1500 mL during surgery based on the pharmacokinetics data of cefazolin. Even with excessive bleeding, administering 3 g of ampicillin/sulbactam every 3 h maintained sufficient plasma concentration. Redosing may be unnecessary unless total bleeding exceeds 20 000 mL."

Journal • PK/PD data • Anesthesia • Transplantation

CASCADE: Cefiderocol and Ampicillin-sulbactam vs. Colistin +/- Meropenem for Carbapenem Resistant A. Baumannii (clinicaltrials.gov) - P4 | N=734 | Recruiting | Sponsor: Rambam Health Care Campus | Not yet recruiting ➔ Recruiting

Enrollment open • Infectious Disease • Pneumonia • Respiratory Diseases

Multidrug-resistant E. Coli in wastewater sources: a comparative study and identification of resistance hotspots. (PubMed, BMC Microbiol) - "Even though resistance was less in community wastewater than hospital wastewater, community outlets might be a source of spreading resistance. Furthermore, wastewater treatment might not be enough to eliminate resistant bacteria from the effluent; as a result, the effluent quality should be continuously monitored and evaluated."

Clinical • Journal

Cervical Necrotizing Fasciitis With Intractable Hiccups. (PubMed, Cureus) - "We report a case of a 61-year-old immunosuppressed man with rheumatoid arthritis on etanercept and past intravenous drug use who presented with intractable hiccups, an unreported feature of cervical necrotizing fasciitis (CNF)...The early surgical debridement, empirical broad-spectrum antibiotics (linezolid, ampicillin-sulbactam), and multidisciplinary teamwork were responsible for a good outcome after delayed diagnosis...This case illustrates the need for a high index of clinical suspicion and the utility of early imaging in immunocompromised patients with atypical presentations. These findings indicate a need for new diagnostic strategies to enhance the outcome of this deadly disease."

Journal • Cardiovascular • Gastrointestinal Disorder • Heart Failure • Immunology • Infectious Disease • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology • Septic Shock

Factors Influencing Oronasal Fistula Formation After Cleft Palatoplasty: Insights from 10-Years of Surgical Outcomes (PSTM 2025) - "Of these, 60 received preoperative ampicillin-sulbactam, with five developing fistulas (8.33%); 17 received cefazolin with seven developing fistulas (41.18%); three received clindamycin, resulting in one fistula (33.3%). This study identifies factors contributing to fistula development at our institution. The use of preoperative cefazolin demonstrated higher fistula rates, suggesting that antibiotics with better oral flora coverage may be a factor in reducing the risk of fistula formation. This suggests the need for reevaluation of SCIP protocol antibiotic choices, which could influence plastic surgery preoperative antibiotic guidelines."

Infectious Disease

Chronic Salmonella Lymphadenitis in a Diabetic Patient (AAO-HNSF 2025) - "The patient received ampicillin-sulbactam, followed by piperacillin-tazobactam and linezolid, eventually ceftriaxone, and finally outpatient trimethoprim-sulfamethoxazole. Although initially concerning for malignancy, this case of cervical lymphadenopathy with abscess formation was found to be a chronic Salmonella infection of unknown source. Management required multidisciplinary care and highlighted the vigilance required in addressing rare infections in diabetic patients."

Clinical • Cardiovascular • Dermatology • Diabetes • Gastroenterology • Gastrointestinal Disorder • Hypertension • Infectious Disease • Metabolic Disorders

Evaluating hospitalized children for preseptal cellulitis: A single-center experience and current literature review. (PubMed, North Clin Istanb) - "The most common finding in patients with preseptal cellulitis was swelling in the eye. The presence of leukocytosis in patients may be used to predict the duration of treatment. Age was an important factor in predicting the duration of clinical improvement in patients."

Journal • Conjunctivitis • Dermatology • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology

Antimicrobial Resistance Profile of Escherichia coli Isolated from Raw Chicken Meat in a Selected Wet Market in Manila City, Philippines. (PubMed, Acta Med Philipp) - "High resistance rates were observed against ampicillin (92%), tetracycline (88%), trimethoprim-sulfamethoxazole (83%), chloramphenicol (79%), ampicillin-sulbactam (75%), amoxicillin-clavulanic acid (67%), fosfomycin (67%), and streptomycin (54%). The majority of the E. coli isolates were still susceptible to a wide range of selected antimicrobial agents, including carbapenems (100%), ceftriaxone (100%), cefepime (100%), cefuroxime (96%), cefotaxime (96%), ceftazidime (96%), piperacillin-tazobactam (96%), aztreonam (96%), cefoxitin (92%), and nitrofurantoin (83%), among others...This study suggests that chickens in wet markets can potentially serve as reservoir hosts for drug-resistance genes, which could transfer to other bacteria and contaminate humans, animals, and the environment within the food production and supply chain. These findings emphasize the need for AMR surveillance and strategies to combat AMR in the Philippines through the One Health approach."

Journal • Infectious Disease

Adult Hospitalized Mycoplasma Cases in a Tertiary Hospital in Japan. (PubMed, Infect Drug Resist) - "He was treated with sulbactam/ampicillin drip infusion and oral administration of minocycline for 2 weeks, and improved. All hospitalized adult patients with mycoplasma pneumonia were treated with antibiotics, such as minocycline and fluoroquinolone, along with corticosteroid co-administration, and all of them ultimately improved, although the chest X-ray findings varied. Antibiotics other than macrolides and corticosteroids may be an effective regimen for the treatment of severe mycoplasma pneumonia with potential macrolide resistance."

Journal • Acute Kidney Injury • Aplastic Anemia • Cough • Hematological Disorders • Infectious Disease • Nephrology • Novel Coronavirus Disease • Oncology • Pneumonia • Pulmonary Disease • Renal Disease • Respiratory Diseases

Multidisciplinary Management of Congenital Subglottic Stenosis in the Setting of Cystic Fibrosis (AAO-HNSF 2025) - "His postop course was complicated by increased peak inspiratory pressures on mechanical ventilation requiring frequent treatments, and tracheitis with H. influenzae and N. meningitidis treated with IV cefepime and ampicillin-sulbactam. This case emphasizes the unified airway theory and need for a broad differential of airway diagnoses in patients with CF who require repeated hospital admissions, unexplained O2 requirement, and intubation. A multidisciplinary approach is critical in the management of these complex airway patients."

Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Inflammation • Influenza • Respiratory Diseases

Comparison of the Clinical Efficacy of Ampicillin/Sulbactam and Cefoperazone/Sulbactam Against Multidrug Resistant Acinetobacter Baumannii Infections in Critically Ill Patients (clinicaltrials.gov) - P=N/A | N=50 | Recruiting | Sponsor: Cairo University

New trial • Infectious Disease

Antimicrobial susceptibility profiling of caprine clinical mastitis pathogens in Punjab, India. (PubMed, Ann Med Surg (Lond)) - "Milk samples were collected aseptically from the cases of clinical mastitis in goats followed by bacterial isolation and antibiotic susceptibility testing for amikacin, amoxicillin, amoxyclav, ampicillin, ampicillin-sulbactam, cefoperazone, cefoperazone-tazobactam, ceftizoxime, ceftriaxone, ceftriaxone-sulbactam, ceftriaxone-tazobactam, ciprofloxacin, colistin, doxycycline, enrofloxacin, erythromycin, gentamicin, moxifloxacin, ofloxacin, oxytetracycline, penicillin-G, streptomycin and tetracycline. As the antimicrobial susceptibility was found to vary among the goats suffering from mastitis as well as the bacteria involved, the antimicrobial susceptibility testing prior to treatment initiation would be crucial in limiting the development of resistance in goats and potentially in human beings as well. The antimicrobial susceptibility profiling in caprine mastitis revealed the multidrug resistant bacterial isolates."

Journal

Cystatin C for gentamicin dosing - a case study. (PubMed, Biochem Med (Zagreb)) - "He was treated with 240 mg gentamicin daily alongside ampicillin/sulbactam penicillin antibiotic. The difference between eGFRcrea and eGFRcys was 148%. Falsely high eGFRcrea in elderly patient led to the supratherapeutic gentamicin concentration even after the standard 240 mg gentamicin dose."

Journal • Anorexia • Cardiovascular • Congestive Heart Failure • Heart Failure • Infectious Disease • Pneumonia • Respiratory Diseases • CST3

Incidence of and risk factors for side effects associated with antibiotic treatment for pneumonia. (PubMed, J Infect Chemother) - "Broad-spectrum antibiotics tended to cause diarrhea more frequently. The use of cefotiam and meropenem was associated with increased liver enzyme levels."

Adverse events • Journal • Dermatology • Hepatology • Infectious Disease • Liver Failure • Pneumonia • Respiratory Diseases

Azygos Vein Thrombosis and Vertebral Osteomyelitis: A Rare Variant of Lemierre Syndrome. (PubMed, J Infect Chemother) - "Initial treatment with intravenous cefepime and metronidazole was administered, followed by ampicillin-sulbactam, and subsequently switched to oral clindamycin due to a drug eruption. This atypical presentation highlights the importance of thorough radiological evaluation in patients with persistent oropharyngeal symptoms and unexpected systemic manifestations, even when the classic internal jugular vein thrombosis is absent. The unique combination of thoracic vertebral osteomyelitis and azygos vein thrombosis represents an extremely rare manifestation with significant implications for diagnosis and management."

Journal • Cardiovascular • Hematological Disorders • Infectious Disease • Inflammation • Otorhinolaryngology • Pulmonary Embolism • Thrombocytopenia • Thrombosis