Alfenta (alfentanil) / Abbott - LARVOL DELTA

Comparison of opioid-free versus weak-opioid general anesthesia on quality of postoperative recovery in soldiers undergoing arthroscopic meniscal surgery. (PubMed, Front Med (Lausanne)) - "Anesthesia induction consisted of alfentanil 0.2 μg/kg in the WOA group and esketamine 0.2 mg/kg in the OFA group...The WOA group received remifentanil 0.1 μg/kg/h and sevoflurane (MAC 0.8-1.0)...Postoperatively, the OFA group reported lower NPRS scores across the first 3 days, required less rescue analgesia, and had a lower incidence of rebound pain. Compared with weak-opioid anesthesia, opioid-free anesthesia significantly improves early postoperative recovery quality, as measured by the QoR15, in soldiers undergoing arthroscopic meniscal surgery."

Journal • Anesthesia • Cardiovascular • Orthopedics • Pain

Exploration of the application of alfentanil in anesthesia induction for pediatric day surgery:a single-center, prospective, double-blind, randomized controlled study (ChiCTR) - P=N/A | N=508 | Not yet recruiting | Sponsor: WeiHai Municipal Hospital; WeiHai Municipal Hospital

New trial • Anesthesia • Pediatrics

Comparison of the effects of alfentanil and sufentanil on the quality of postoperative recovery in patients undergoing non-beating heart coronary artery bypass grafting (ChiCTR) - P=N/A | N=330 | Not yet recruiting | Sponsor: The Second Hospital of Hebei Medical University; The Second Hospital of Hebei Medical University

New trial

QSAR-based physiologically based pharmacokinetic (PBPK) modeling for 34 fentanyl analogs: model validation, human pharmacokinetic prediction and abuse risk insights. (PubMed, Front Pharmacol) - "For structurally similar, clinically characterized analogs (e.g., sufentanil, alfentanil), predictions of key PK parameters (e.g., T1/2, Vss) fall within 1.3-1.7-fold of clinical data, supporting the framework's utility for generating testable hypotheses about the PK of understudied analogs. It not only fills the data gap for fentanyl analog hazard assessment but also provides a scalable modeling strategy for PK evaluation of other NPS or illicit drugs."

Journal • PK/PD data

The median effective dose of alfentanil in combination with etomidate for inhibiting cardiovascular responses in elderly patients after laryngeal mask insertion (ChiCTR) - P4 | N=30 | Not yet recruiting | Sponsor: Hangzhou Third People's Hospital; Hangzhou Third People's Hospital

New P4 trial • Anesthesia • Cardiovascular • Pain

Study on the Effective Dose of Alfentanil Combined with Ciprofol in Inhibiting Intraoperative Body Movement Responses in Patients Undergoing Breast Lump Resection (ChiCTR) - P1 | N=40 | Not yet recruiting | Sponsor: Suzhou Municipal Hospital; Suzhou Municipal Hospital

New P1 trial

Dose-Response Study of Remimazolam Combined with Different Doses of Alfentanil for Sedation in Pediatric Gastroscopy (ChiCTR) - P=N/A | N=80 | Not yet recruiting | Sponsor: Qinghai Women and Children's Hospital; Qinghai Women and Children's Hospital

New trial • Anesthesia • Pediatrics

Study on the Sedative and Analgesic Effects of Propofol and Alfentanil in Pain-Free Abortion Surgery (ChiCTR) - P=N/A | N=213 | Not yet recruiting | Sponsor: The Second Hospital of Dalian Medical University; The Second Hospital of Dalian Medical University

New trial • Pain

Postinduction hypotension with ciprofol or propofol combined with alfentanil in geriatric patients-a single-centre, double-blind, randomised controlled trial (ChiCTR) - P4 | N=202 | Not yet recruiting | Sponsor: Zhongshan Hospital, Fudan University; Zhongshan Hospital, Fudan University

New P4 trial • Geriatric Disorders • Hypotension

ED50 of alfentanil for tracheal intubation in obese patient. (ChiCTR) - P=N/A | N=50 | Not yet recruiting | Sponsor: Zhongshan Hospital (Xiamen Branch), Fudan University, Xiamen; Zhongshan Hospital (Xiamen Branch), Fudan University, Xiamen

Intubation • New trial • Obesity

Efficacy and Safety of the Remimazolam-Alfentanil Combination for Assisted Reproductive Therapy (ChiCTR) - P=N/A | N=400 | Not yet recruiting | Sponsor: The First Affiliated Hospital, College of Medicine, Zhejiang University; The First Affiliated Hospital, College of Medicine, Zhejiang University

New trial

Effect of alfentanil combined with fascia iliaca nerve block on emergence agitation undergoing chosed reduction of lower extremity fractures operation (ChiCTR) - P=N/A | N=60 | Not yet recruiting | Sponsor: Anqing Municipal Hospital; Anqing Municipal Hospital

New trial • Musculoskeletal Diseases • Orthopedics

OPIOID AVAILABILITY FOR PAIN IN PEDIATRIC ONCOLOGY POPULATIONS IN LOW- AND MIDDLE-INCOME COUNTRIES: A PAUCITY OF RESEARCH (SIOP 2025) - "The most frequently reported opioids were morphine and fentanyl, in 11 and 10 articles respectively, followed by tramadol (4), pethidine, methadone, and codeine (2 each), and tapentadol, remifentanil, alfentanil, and oxycodone (one each). Our finding of limited opioid research in pediatric oncology in LMICs highlights a significant research gap and possibly limited access to opioids for pain in LMICs in pediatric oncology. In the context in which opioid distribution is unequal and inequitable generally, this is especially concerning for the vulnerable pediatric oncology population."

Clinical • Pain • Palliative care • Pediatrics

The effects of alfentanil on emergence agitation in children under general anesthesia: a meta-analysis of randomized controlled trials. (PubMed, Front Pediatr) - "However, further high-quality studies are needed to verify the effect of alfentanil in preventing the occurrence of EA in children undergoing general anesthesia. https://www.crd.york.ac.uk/PROSPERO/view/CRD42023448260, PROSPERO CRD42023448260."

Journal • Retrospective data • Review • Anesthesia • Pain • Pediatrics

SED-ERCP: EEG and Pain Monitor Data Under Anesthesia to Study Pharmacodynamic Effects of Opioids and Sedatives (clinicaltrials.gov) - P=N/A | N=20 | Not yet recruiting | Sponsor: Chi Kwan Fung

New trial • Anesthesia • Pain

Prediction Model for Remimazolam Dosing Based on Patient Characteristics to Enhance Anesthesia Management (ASA 2025) - "Background:The combination of alfentanil and remimazolam tosylate is widely used in painless gastroscopy anesthesia. While Logistic Regression performed best, Random Forest is preferred for stability and generalization. BMI and heart rate are key factors in optimizing remimazolam dosing, with gender and administration time having moderate effects. Incorporating patient characteristics into predictive models enhances safety and anesthesia efficacy."

Clinical • Anesthesia • CNS Disorders • Depression • Immunology • Infectious Disease • Psychiatry • Respiratory Diseases

Anesthesia management for a case of acute myocardial infarction with moderate to severe aortic valve stenosis undergoing total gastrectomy (ASA 2025) - "During the operation, alfentanil was pumped to control stress reaction, and landiolol was used to control ventricular rate. After the operation, epidural analgesia was used, and the patient recovered smoothly and was discharged from the hospital."

Clinical • Anesthesia • Atrial Fibrillation • Cardiovascular • Coronary Artery Disease • Heart Failure • Myocardial Infarction

Precision sedation with novel single syringe multimodal opioid or non-opioid 6-2-2 mixtures. (PubMed, J Clin Anesth) - "Adjusted for age and weight, the bolus dose of the 6-2-2 mixture met the sedation requirements for ocular blocks in most patients with favorable outcomes and minimal airway or hemodynamic compromise regardless of which mixture was used."

Journal • Anesthesia • Ophthalmology • Pain

Effect of low-dose ciprofol on postoperative nausea and vomiting following gynecologic day surgery: a randomized controlled trial. (PubMed, Front Med (Lausanne)) - P1 | "Both groups received remimazolam (6 mg/kg/h) until asleep, then alfentanil (20 μg/kg) and mivacurium (0.2 mg/kg) intravenous, followed by maintenance infusions of remimazolam and alfentanil. Low-dose ciprofol can effectively prevent PONV in PACU after gynecological day surgery under general anaesthesia remazolam combined with afentanil, but its effect is limited and cannot reduce the incidence of emetic episodes or nausea within 24 h after surgery. https://www.chictr.org.cn, identifier ChiCTR2300077247."

Journal • Anesthesia • Cardiovascular • Gynecology • Hypertension • Hypotension

Diagnostic value of repeat endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) (ERS 2025) - "Midazolam use remained unchanged (mean 2.6 mg), but increased alfentanil dosing (518.4 µg vs. 862.9 µg) notably reduced significant discomfort (29% vs. 2.5%). Repeat EBUS-TBNA adds diagnostic value when used for IHC and molecular testing, but its use is limited following initial negative result. Sedation optimization and sampling of all abnormal stations should be prioritized. Alternative diagnostics should be considered beyond 2 attempts."

Endobronchial ultrasound • Anesthesia

The effectiveness and experience of Endobronchial Ultrasound (ERS 2025) - "Procedures were performed under Alfentanil and Midazolam conscious sedation. EBUS is a minimally invasive technique that is effective in providing specimens suitable for cytological and molecular diagnosis of lung cancer. Despite being invasive, the patients favourably rated their experience of EBUS and found the procedure less painful and more acceptable than expected."

Endobronchial ultrasound • Anesthesia • Lung Adenocarcinoma • Lung Cancer • Solid Tumor • Squamous Cell Carcinoma • EGFR • KRAS

Trade-offs in airway stability vs. hemodynamic safety: a retrospective study of alfentanil-sevoflurane-propofol anesthesia for tracheal intubation. (PubMed, Clinics (Sao Paulo)) - "While the propofol-sevoflurane-alfentanil combination improved airway conditions, it caused universal hypotension and frequent bradycardia. Fixed-dose alfentanil (10 µg/kg) without titration may be unsafe in spontaneous breathing protocols due to respiratory depression."

Intubation • Journal • Retrospective data • Anesthesia • Cardiovascular • CNS Disorders • Depression • Hypotension • Pain • Psychiatry

Standardised Drug Provocation Testing in Perioperative Hypersensitivity (clinicaltrials.gov) - P=N/A | N=50 | Completed | Sponsor: University Hospital, Antwerp | Recruiting ➔ Completed | Trial completion date: Oct 2025 ➔ Jun 2025 | Trial primary completion date: Oct 2025 ➔ Jun 2025

Trial completion • Trial completion date • Trial primary completion date • Allergy • Immunology

Safety and efficacy of remimazolam combined with alfentanil in flexible fiberoptic bronchoscopy: A randomized controlled trial. (PubMed, J Int Med Res) - "It also shortened recovery time and improved both operator and patient comfort scores. These results support remimazolam plus alfentanil as a safe, effective, and well-tolerated alternative sedation regimen in this setting."

Clinical • Journal • Anesthesia • Cough • Hypotension • Pain • Respiratory Diseases

Expanding Fentanyl Analog Testing to Include Brain Specimens: Method Validation and Homogenate Stability Assessment. (PubMed, J Anal Toxicol) - "XXXXX recently added brain to its fentanyl analog testing method for 14 analogs (fluoroisobutyryl fentanyl, acetyl fentanyl, acryl fentanyl, alfentanil, butyryl fentanyl, carfentanil, fentanyl, para-fluorofentanyl, furanyl fentanyl, methoxyacetyl fentanyl, norcarfentanil, norfentanyl, sufentanil, and valeryl fentanyl) and 3 U-series drugs (U-47700, U-48800, and U-49900). Brain homogenate stability was improved when frozen and was not impacted by the addition of 1% sodium fluoride. The study herein provides insight into the feasibility of testing brain for fentanyl analogs and their stability under various storage conditions, contributing valuable data to the limited literature on brain toxicology testing."

Journal