Alfenta (alfentanil) / Abbott - LARVOL DELTA

Comparison of Ciprofol Versus Propofol for the General Anaesthesia During Gynecological Day Surgery: A Prospective, Randomized, Double-Blind, Non-Inferiority Trial. (PubMed, Drug Des Devel Ther) - "Anesthesia induction in the ciprofol group: ciprofol 0.5 mg/kg was given intravenously within 1 minute, alfentanil 20 μg/kg was given intravenously within 30 seconds, mivacurium 0.2 mg/kg was given intravenously within 30 seconds, and anesthesia maintenance: ciprofol 1.25 mg/kg/h combined with alfentanil 40 μg/kg/h was given intravenously. However, the awakening time of the ciprofol group was significantly longer than that of the propofol group (7.57 vs 5.52 min). Ciprofol demonstrated non-inferior efficacy to propofol for gynecological day surgery anesthesia, while offering superior hemodynamic stability and reduced adverse effects."

Clinical • Head-to-Head • Journal • Anesthesia

Effect of alfentanil on rapid perioperative recovery in day surgery patients —— a randomized, double-blind, clinical comparative study (ChiCTR) - P4 | N=160 | Completed | Sponsor: Anqing Municipal Hospital; Anqing Municipal Hospital | Recruiting ➔ Completed

Trial completion • Gynecology

Anesthesia management for a case of acute myocardial infarction with moderate to severe aortic valve stenosis undergoing total gastrectomy (ASA 2025) - "During the operation, alfentanil was pumped to control stress reaction, and landiolol was used to control ventricular rate. After the operation, epidural analgesia was used, and the patient recovered smoothly and was discharged from the hospital."

Clinical • Anesthesia • Atrial Fibrillation • Cardiovascular • Coronary Artery Disease • Heart Failure • Myocardial Infarction

Different combinations of anesthetics in transperineal prostate biopsy in elderly men: A prospective, randomized, controlled monocentric trial (PubMed, Zhonghua Nan Ke Xue) - "For elderly male patients undergoing transperineal prostate biopsy under intravenous anesthesia with preservation of spontaneous breathing, the combined use of remimazolam and alfentanil can achieve more stable intraoperative hemodynamics, faster recovery from anesthesia and a lower incidence of perioperative adverse reactions, and produce an even better anesthetic effect with a small dose of propofol to suppress the body movement at the time of needle puncture."

Clinical • Journal • Anesthesia • CNS Disorders • Depression • Pain • Psychiatry

Effect of Different Sequences of Administration of Remimazolam and Alfentanil on Adverse Reactions During the Anesthetic Induction Period in Gynecological Day Surgery Patients (ChiCTR) - P4 | N=104 | Recruiting | Sponsor: Weifang People's Hospital; Weifang People's Hospital

New P4 trial • Anesthesia

Safety and efficacy of slow induction of amnesia analgesia with alfentanil combined with dexmedetomidine in elderly patients undergoing orthopedic surgery : a randomized, controlled study (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: Hefei First People's Hospital; Hefei First People's Hospital

New trial • CNS Disorders • Musculoskeletal Diseases • Orthopedics

A Study on the Efficacy and Safety of Different Doses of Dexmedetomidine for Bronchoscopy in ASA Class III Patients (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: Gansu Provincial Hospital; Gansu Provincial Hospital

New trial

Evaluating the efficacy and safety of lidocaine combined with alfentanil and propofol in painless gastroenteroscopy: a randomized, double-blind, controlled clinical trial. (ChiCTR) - P=N/A | N=240 | Recruiting | Sponsor: The First Affiliated Hospital of Baotou Medical College; The First Affiliated Hospital of Baotou Medical College

New trial • Pain

A Randomized, Double-Blind, Controlled Clinical Trial Evaluaing the Efficacy and Safety of Remimazolam-Alfentanil and Ciprofol-Alfentanil for Painless Fiberoptic Bronchoscopy (ChiCTR) - P4 | N=204 | Not yet recruiting | Sponsor: Xiangya Hospital, Central South University; Xiangya Hospital, Central South University

New P4 trial • Pain

Clinical application study of propofol combined with alfentanil anesthesia in tumor interventional surgery (ChiCTR) - P4 | N=202 | Not yet recruiting | Sponsor: Lishui Central Hospital; Lishui Central Hospital

New P4 trial • Anesthesia

Remimazolam Besylate-Alfentanil Combination for Pain-Free Colonoscopy: Clinical Outcomes and Influencing Factors (ChiCTR) - P=N/A | N=150 | Not yet recruiting | Sponsor: Zhongyi Northeast International Hospital Co., Ltd; Zhongyi Northeast International Hospital Co., Ltd

New trial • Pain

The effect of propofol combined with alfentanil target-controlled infusion compared with intermittent bolus injection in gastroenteroscopy (ChiCTR) - P4 | N=188 | Recruiting | Sponsor: Affiliated Hospital of Yan'an University; Affiliated Hospital of Yan'an University

New P4 trial

A comparative study of the anesthetic effect of Alfentanil versus Sufentanil in laryngeal microsurgery (ChiCTR) - P=N/A | N=92 | Recruiting | Sponsor: Ziyang Central Hospital; Ziyang Central Hospital

New trial • Anesthesia • Otorhinolaryngology

Efficacy and safety of remimazolam besylate combined with alfentanil for the induction and maintenance of general anesthesia in obese patients (ChiCTR) - P4 | N=330 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University

New P4 trial • Anesthesia • Obesity

Pharmacodynamics study of remimazolam besylate in anxious patients undergoing gastroscopy: a biased-coin design up-and-down sequential allocation trial. (PubMed, BMC Anesthesiol) - P=N/A | "When combined with 5 µg/kg alfentanil, the ED50 and ED90 of remimazolam besylate for inhibiting body movement response within two minutes of gastroscopy in anxious patients were 0.175 mg/kg and 0.251 mg/kg, respectively. Anxiety increased the requirement for remimazolam besylate in patients undergoing gastroscopy, but it did not increase the risk of prolonged discharge time or adverse effects."

Clinical • Journal • PK/PD data • Mood Disorders • Psychiatry

Evaluation of Therapeutic Opioids in Hair of Neonatal and Pediatric Patients. (PubMed, Drug Test Anal) - "These patients were treated with medically approved novel synthetic opioids (fentanyl, remifentanil, sufentanil, or alfentanil) and traditional opioids (morphine, methadone, and hydromorphone) during their clinical treatment. The metabolite ratio of β-hydroxyfentanyl to fentanyl was particularly well suited for children and neonatal patients. In conclusion, concentration ranges, metabolite ratios, and dose correlations of the studied opioids in pediatric hair were established, providing insights into opioid incorporation pathways."

Journal • Pediatrics

Effect of Sedation/Analgesia During Colonoscope on Abdominal Pain After Examination. (PubMed, Asian J Anesthesiol) - "Optimal S/A with midazolam and alfentanil decreases the severity and duration of postcolonoscopic abdominal pain."

Journal • Anesthesia • Hypotension • Mood Disorders • Pain • Psychiatry

Comparison of fentanyl and alfentanil in combination with atropine for premedication of dogs undergoing radiotherapy. (PubMed, Vet Anaesth Analg) - "Since the two protocols produced comparable clinical effects and were both found suitable for dogs undergoing repeated radiotherapy, fentanyl is recommended over alfentanil in countries where it is licensed."

Journal • Anesthesia • CNS Disorders • Ophthalmology

Optimizing adjuvant strategies for sevoflurane-related emergence delirium: a Bayesian network meta-analysis in pediatric surgery. (PubMed, Front Pharmacol) - "Among all interventions, dexmedetomidine combined with alfentanil was the most effective in reducing ED risk for tonsillectomy/adenoidectomy, achieving a SUCRA ranking of 94.63% (logRR = -2.82). Targeted use of dexmedetomidine-based combinations was found to be particularly effective across various surgeries, while fentanyl and propofol-midazolam combinations excelled in specific contexts. This study underscores the importance of tailoring anesthetic adjuvant strategies to specific surgical sites to reduce the risk of ED in pediatric patients, and provides a valuable reference for optimizing anesthetic care in this vulnerable population."

Journal • Retrospective data • Review • Anesthesia • CNS Disorders • Gastroenterology • Ophthalmology • Otorhinolaryngology • Pediatrics

The median Effective Dose (ED50) and the 95% Effective Dose (ED95) of alfentanil in inhibiting responses to cervical dilation when combined with ciprofol during hysteroscopic procedure: a prospective, double-blind, dose-finding clinical study. (PubMed, BMC Anesthesiol) - P=N/A | "For women undergoing hysteroscopic surgery, a dose of 10-12 µg·kg-1 of alfentanil was associated with significant ciprofol-sparing effect, earlier anesthesia emergence, better postoperative analgesia, and less unexpected hemodynamic events compared with sufentanil, but 14 µg·kg-1 alfentanil had the risk of transient desaturation and delayed anesthesia recovery. Indications and the optimal dose of alfentanil in this patient population need further clarification."

Clinical • Journal • Anesthesia • Gynecology • Hypotension • Pain

Alfentanil Enhanced the Sedation of Remimazolam During Anaesthesia Induction in Patients Undergoing Urological Day Surgery: A Randomised Controlled Trial. (PubMed, Drug Des Devel Ther) - P4 | "No significant differences were observed between groups in the total administration of alfentanil, ephedrine, rocuronium, or crystalloid infusion volumes. But the potential mechanisms need further study. The trial was registered before patient enrolment at http://www.chictr.org.cn (ChiCTR2200064130, principal investigator: Xuehai Guan; date of registration: 27 September 2022, https://www.chictr.org.cn/showproj.html?proj=179023)."

Clinical • Journal • Anesthesia • Cardiovascular • Hypertension • Hypotension

Pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated neonates. (PubMed, Cochrane Database Syst Rev) - "Morphine may have little to no effect on PIPP or duration of ventilation (evidence very uncertain). Morphine may not increase the risk of hypotension and probably does not reduce the incidence of severe IVH. Alfentanil may reduce CHEOPS and heart rate change from baseline (evidence very uncertain). Meperidine may reduce BPS. Compared to midazolam, morphine may have little to no effect on PIPP scores, and may result in a large reduction in the duration of ventilation (evidence very uncertain). No studies reported on physiological and behavioural indicators or haemodynamic changes. Morphine may not reduce the incidence of severe IVH, compared to midazolam (low-certainty evidence). Compared to placebo, midazolam may reduce PIPP scores, and has little to no effect on the duration of ventilation or on the risk of severe IVH (low to very low-certainty evidence); ketamine may reduce CHEOPS change, and have little to no effect on heart rate change, or on mean arterial blood..."

Journal • Review • Critical care • Hypotension • Pain

Quantitative Prediction of Drug-Drug Interactions Arising from CYP3A4 Induction using Chimeric Mice with Humanized Liver. (PubMed, Xenobiotica) - "After repeated administration of rifampicin or efavirenz as CYP inducers to chimeric mice, the relative expression of human CYP3A4 in their livers was measured and plotted against the area under the concentration-time curve (AUC) of rifampicin and efavirenz, respectively, in plasma on the final day of administration. The intrinsic clearance was incorporated into a constructed physiologically based pharmacokinetic model, which successfully predicted the pk change of midazolam or alfentanil coadministered with a CYP inducer or not. The results confirmed that our approach is useful to improve the prediction accuracy of CYP3A4 induction in the preclinical phase."

Journal • Preclinical • CYP3A4

Observation on the Clinical Effect of Remimazolam Sulfonate Combined with Afentanil in Gastric and Colon Endoscopy under Painless Condition (ChiCTR) - P=N/A | N=100 | Not yet recruiting | Sponsor: Jiangxi Provincial People's Hospital; Jiangxi Provincial People's Hospital

New trial • Pain

The application of alfentanil in painless abortion surgery in plateau area (ChiCTR) - P=N/A | N=28 | Completed | Sponsor: Shannan Maternal and Child Health Hospital; Shannan Maternal and Child Health Hospital

New trial • Pain