Alfenta (alfentanil) / Abbott - LARVOL DELTA

The Median Effective Concentration (EC50) of Alfentanil Combined with Propofol Closed-Loop Targeted Infusion in Super-Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP). (PubMed, Drug Des Devel Ther) - "The EC50 of alfentanil combined with propofol by closed-loop target-controlled infusion during ERCP in super-elderly patients is 36.52ng/mL. At this concentration level, the patients can be satisfied with surgical anesthesia and maintain relatively stable hemodynamics."

Clinical • Journal • Anesthesia

Population Pharmacokinetics of Alfentanil in Children. (PubMed, J Clin Pharmacol) - "These regimens should be prospectively evaluated to ensure their safety and confirm their efficacy. Overall, this study provides valuable insights into pharmacokinetics and dosing of alfentanil in children."

Journal • PK/PD data • Anesthesia • Pain • Pediatrics

Pharmacokinetics and Pharmacodynamics of Analgesic and Anesthetic Drugs in Patients During Cardiac Surgery With Cardiopulmonary Bypass: A Narrative Review. (PubMed, Anesth Analg) - "The breakdown of studies by main topic was as follows: propofol (9 articles), sevoflurane (4), remifentanil (3), isoflurane (2), fentanyl (2), and sufentanil (2), and alfentanil (1). The clinical implication of the altered drug responses after CPB remains challenging in this high-risk population. Key takeaways include the necessity of considering patient-specific factors, utilizing objective monitoring tools, and recognizing potential drug alterations due to CPB."

Journal • PK/PD data • Anesthesia • Cardiovascular • Pain

Safety of remimazolam in deep sedation during flexible fiberoptic bronchoscopy: a prospective, randomized controlled trial. (PubMed, BMC Anesthesiol) - P4 | "During the maintenance of elderly patients under deep sedation with FFB, remimazolam exhibited superior safety than propofol, particularly in terms of respiratory depression and cardiovascular inhibition."

Clinical • Journal • Anesthesia • Cardiovascular • CNS Disorders • Depression • Hypotension • Pain • Psychiatry

HISPANIC PATIENTS WITH IBD WHO UNDERWENT BOWEL RESECTION ARE LESS LIKELY TO RECEIVE ALL-CAUSE OPIOID AND NON-OPIOID AGENTS USED IN MULTIMODAL PAIN MANAGEMENT (SSAT 2025) - "Medications, which were identified using RXNORM codes, assessed included opioids (weak/strong), NSAIDs, gabapentin/pregabalin, antispasmodics, TCAs, and SSRIs. Among 70,654 IBD patients, non-Hispanic whites (NHW) comprised 49.4% (34,922), Hispanics 16.2% (11,457), and non-Hispanic blacks (NHB) 11.9% (8,431). These findings emphasize differences in all-cause pain management among IBD patients undergoing bowel resections. Hispanic patients consistently used fewer opioids and non-opioid pain medications compared to NHW patients, despite similar resection rates. Our findings may reflect differences in disease severity, pain perception, or healthcare access on the basis of ethnicity.Table 1."

Clinical • Addiction (Opioid and Alcohol) • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Pain • Ulcerative Colitis

Comparison of Propofol and Sevoflurane as Anesthesia Maintenance Agents in Relation to Postoperative Pain, Nausea and Vomiting During Endoscopic Retrograde Cholangio-Pancreatography: A Prospective, Single-Center, Randomized, Single-Blind Pilot Study. (PubMed, Cureus) - "Moreover, in both groups, all patients received balanced anesthesia based on alfentanil and rocuronium. Conclusion There appeared to be no difference in terms of postoperative pain, nausea and vomiting after ERCP in adults, based on the choice of maintenance anesthetic agent (sevoflurane versus propofol). However, the results of this pilot study should be confirmed in a larger sample."

Journal • Anesthesia • Pain

Successful sedation with remimazolam and alfentanil in a child susceptible to malignant hyperthermia: a case report. (PubMed, BMC Anesthesiol) - "This case demonstrates the feasibility of remimazolam-based sedation in genetically confirmed pediatric MH patients, supporting its safety profile in this population. Further multicenter studies are needed to establish standardized protocols."

Journal • Anesthesia • Pediatrics • RYR1

Alfentanil combined with dexmedetomidine for painless conscious sedation in outpatient gastroscopy in obese patients (ChiCTR) - P=N/A | N=120 | Completed | Sponsor: Department of Anesthesiology, Shiyan People's Hospital (People's Hospital Affiliated to Hubei Medical College); Department of Anesthesiology, Shiyan P

New trial • Anesthesia • Obesity • Pain

The observation of the effects of different doses of alfentanil for pediatric bronchoscopy without muscle relaxants (ChiCTR) - P=N/A | N=300 | Not yet recruiting | Sponsor: Linyi People's Hospital; Linyi People's Hospital

New trial • Pediatrics • Respiratory Diseases

The safety and efficacy of alfentanil-propofol combined total intravenous anesthesia without neuromuscular blocking agents during daytime hysteroscopy induction and maintenance (ChiCTR) - P=N/A | N=250 | Not yet recruiting | Sponsor: Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University; Qilu Hospital(Qingdao),Cheeloo College of Medicine, Shandong University

New trial • Anesthesia • Gynecology

The Median Effective Dose and studies on Pharmacokinetics of Afentanil combined with Remimazolam Tosilate for hysteroscopic Surgery (ChiCTR) - P4 | N=100 | Not yet recruiting | Sponsor: Qingdao Women and Children's hospital; Qingdao Women and Children's hospital

New P4 trial

Application effect of cyclopropofol in endoscopic retrograde cholangiopancreatography under nasal high-flow oxygen therapy in elderly patients (ChiCTR) - P4 | N=108 | Recruiting | Sponsor: First Affiliated Hospital of Gannan Medical University; First Affiliated Hospital of Gannan Medical University

New P4 trial • Gastroenterology • Pain

Comparison of Oliceridine and Alfentanil in Fiberoptic Bronchoscopy under General Anesthesia with Laryngeal Mask Airway (ChiCTR) - P=N/A | N=90 | Not yet recruiting | Sponsor: Anshan Central Hospital; Anshan Central Hospital

New trial • Anesthesia • Lung Cancer • Oncology • Pulmonary Disease

The influence of alfentanil on the effective dose of etoposide during anesthesia induction in patients undergoing hysteroscopic surgery (ChiCTR) - P=N/A | N=60 | Not yet recruiting | Sponsor: Hangzhou Obstetrics and Gynecology Hospital; Hangzhou Obstetrics and Gynecology Hospital

New trial • Anesthesia

Determination of the 50% effective dosage of cyclopofol for pediatric fiberoptic bronchoscopy in conjunction with alfentanil (ChiCTR) - P4 | N=50 | Not yet recruiting | Sponsor: Ganzhou Maternal and Child Health Hospital; Ganzhou Maternal and Child Health Hospital

New P4 trial • Infectious Disease • Pediatrics • Pneumonia

Observation on the Anesthetic Effect of Low-dose Remazolam Combined with Ciprofloxacin for Painless Gastroscopy (ChiCTR) - P=N/A | N=220 | Not yet recruiting | Sponsor: The Third Affiliated Hospital of Guangzhou University of Chinese Medicine; The Third Affiliated Hospital of Guangzhou University of Chinese Medicine

New trial • Anesthesia • Pain

Clinical Observation of Dexmedetomidine Combined with Alfentanil for Painless Gastroscopy in Elderly Patients (ChiCTR) - P=N/A | N=140 | Completed | Sponsor: Shiyan City People's Hospital; Shiyan City People's Hospital

New trial • Pain

Application of alfentanil combined with propofol in oocyte retrieval (ChiCTR) - P=N/A | N=130 | Recruiting | Sponsor: The First Affiliated Hospital of Guangxi Medical University; The First Affiliated Hospital of Guangxi Medical University

New trial • Infertility • Sexual Disorders

Effectiveness of opioid-sparing and opioid-free anesthesia in daytime hysteroscopic surgery without intubation of general anesthesia (ChiCTR) - P=N/A | N=144 | Not yet recruiting | Sponsor: The First Affiliated Hospital,Zhejiang University School of Medicine; The First Affiliated Hospital,Zhejiang University School of Medicine

New trial • Anesthesia • Pain

Comparison of the inhibitory effects of ciprofol-lidocaine and ciprofol-alfentanil on body movements during oocyte retrieval surgery (ChiCTR) - P=N/A | N=150 | Not yet recruiting | Sponsor: General Hospital of Northern Theater Command; General Hospital of Northern Theater Command

New trial • Infertility • Sexual Disorders

Efficacy and safety of remimazolam with alfentanil in bronchoscopy in adults: a randomized, double-blind, controlled clinical study (ChiCTR) - P4 | N=118 | Completed | Sponsor: Lishui People's Hospital; Lishui People's Hospital

New P4 trial

Study on the Median Effective Dose of a Propofol-Alfentanil-Lidocaine Mixture in Inhibiting Body Movement Responses During Ocular Regional Blockade (ChiCTR) - P4 | N=150 | Not yet recruiting | Sponsor: The Zhongshan Ophthalmic Center, Sun Yat-sen University; The Zhongshan Ophthalmic Center, Sun Yat-sen University

New P4 trial

Comparison of the inhibitory effects of lidocaine and alfentanil on body movement during painless oocyte retrieval surgery: a non inferiority study (ChiCTR) - P=N/A | N=500 | Recruiting | Sponsor: General Hospital of Northern Theater Command; General Hospital of Northern Theater Command

New trial • Infertility • Pain • Sexual Disorders

Anesthesia effects of different doses of fospropofol disodium for painless colonoscopy diagnosis and treatment. (PubMed, Front Med (Lausanne)) - P4 | "In painless colonoscopy, fospropofol disodium 12.5 mg/kg combined with alfentanil 5 μg/kg has a high success rate of first-time sedation and low hemodynamic impact, which has some clinical advantages. ChiCTR2400090788."

Journal • Anesthesia • Hypotension • Pain

Safety and efficacy analysis of ciprofol combined with low-dose alfentanil in sedation of patients during transesophageal echocardiography: a randomized double-blind controlled study. (PubMed, Curr Med Res Opin) - P4 | "Ciprofol combined with low-dose alfentanil demonstrated a more favorable safety profile compared to propofol, with significantly reduced rates of adverse events and injection pain. ChiCTR2400081723."

Clinical • Journal • Anesthesia • Cardiovascular • Cough • Pain • Respiratory Diseases