AN-0128 / Pfizer - LARVOL DELTA

Chairside clinicomicrobiological assessment of subgingival boric acid irrigation in periodontitis patients: A randomized controlled trial. (PubMed, J Indian Soc Periodontol) - "Elemental boron has a positive role in many functions in the human body, such as immune regulation, wound healing, bone health maintenance, etc. A boron-containing molecule (AN0128) has shown additional antimicrobial properties against virulent red-complex bacteria...Outcomes of the present trial demonstrated boron's significant role in clinical improvements. Adjunctive subgingival boric acid irrigation can be effective in healing following phase-I therapy."

Clinical • Journal • Dental Disorders • Periodontitis

Halogenated Dipyridine Alkaloids from Actinoalloteichus cyanogriseus and Its Mutant Strain upon Precursor Feeding. (PubMed, J Nat Prod) - "Nineteen uncovered 2,2'-dipyridine alkaloids (1-19), along with six previously reported analogues (20-25), were isolated from the wild strain Actinoalloteichus cyanogriseus OUCMDZ-413 and its mutant strain CRM005...The molecular structures of these compounds were determined through spectroscopic analysis. Notably, the novel compounds showed cytotoxicity against the HCT-116, B16, and K562 tumor cell lines, with IC50 values ranging from 0.16 to 11 μM."

Journal • Oncology

Ring Expansion of Cyclic Boronates via Oxyboration of Arynes. (PubMed, J Am Chem Soc) - "A series of 2-aryl-1,3,2-dioxaborolane derivatives were reacted with aryne precursors in the presence of CsF to give the corresponding ring-expanded seven-membered borinic acid esters via selective boron-oxygen bond activation. Preliminary experimental mechanistic studies and density functional theory (DFT) calculations suggest that this unprecedented aryne oxyboration proceeds through the formation of boron ate complexes of arylboronates with CsF, followed by aryne insertion into the boron-oxygen bond."

Journal