AR1003 / ariBio - LARVOL DELTA

DICER1-syndrome with manifestation of genital embryonal rhabdomyosarcoma in the first year of life: case report (PubMed, Probl Endokrinol (Mosk)) - "Molecular genetic examination revealed a heterozygous pathogenic variant p.Arg1003Ter in the DICER1 gene (NM_030621.4). The presented case emphasizes the importance of molecular genetic diagnosis of DICER1 syndrome in a diagnostic algorithm in the management of patients with TFND and history of malignancy. Considering ERMS of genital tract as a probable component of DICER1 syndrome it is necessary to screen for other manifestations of the disease as well."

Journal • Oncology • Rhabdomyosarcoma • Sarcoma • Solid Tumor • DICER1

Vitexin and Isovitexin Act Through Inhibition of Insulin Receptor to Promote Longevity and Fitness in Caenorhabditis elegans. (PubMed, Mol Nutr Food Res) - "Vitexin and isovitexin might inhibit IIS pathway by occupying the ATP-binding site pocket of IGFR, subsequently decreasing IGFR expression, thereby promoting longevity and fitness."

Journal • IR • PI3K

A promising strategy for investigating the anti-aging effect of natural compounds: a case study of caffeoylquinic acids. (PubMed, Food Funct) - "Moreover, ASP1153, GLU1080, ASP1086, and ARG1003 were the key amino acid residues during the interaction of these 6 compounds with IGFR...Further studies demonstrated that 3,5-diCQA induced longevity effects by downregulating the insulin/insulin-like growth factor signaling (IIS) pathway. This study suggested that the combination of molecular docking and genetic analysis of specific worm mutants could be a promising strategy to reveal the anti-aging mechanisms of small molecule natural compounds."

Clinical • Journal

Korean startup develops potential Covid-19 cure to stop cytokine storm (Pulse by Maeil Business News Korea) - "Ari Bio, a Korean cell therapy developer, said...that its investigational acute sepsis drug is under priority regulatory review in Korea for the treatment of COVID-19 patients with severe pneumonia....The company hopes to conduct clinical trials simultaneously in Korea and the United States....The company is also preparing to produce a test drug in the U.S. while asking for a pre-NDA meeting with the Food and Drug Administration (FDA) ahead of its filing for phase 1 study approval, Jung added, expecting the initiation of the first clinical trial sometime around September or October....In an animal test of mice...40 percent of the mice treated with AR1003 survived on the seventh day..."

IND • New P1 trial • Non-US regulatory • Preclinical • Infectious Disease • Novel Coronavirus Disease