AB-001 / Aubrak Therapeutics - LARVOL DELTA

Therapeutic evaluation of [212Pb]Pb-AB001 and [177Lu]Lu-PSMA-617 in a mouse model of disseminated prostate cancer. (PubMed, Eur J Nucl Med Mol Imaging) - "[212Pb]Pb-AB001 showed significant efficacy against micrometastases and advantages over [177Lu]Lu-PSMA-617 in preventing or treating early bone metastases for the investigated injected activities. This implies clinical potential for treating mCRPC, including patients at risk of early metastatic disease, but further studies including dosimetry and toxicity analyses are required with regards to activity levels."

Journal • Preclinical • Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

INTERIM RESULTS FROM THE PHASE I IBC -01-01 STUDY: THE FIRST IMMUNE CHECKPOINT INHIBITOR THERAPY IN PATIENTS WITH EARLY ALZHEIMER'S DISEASE (ADPD 2025) - "IBC -01-01 is a Phase I clinical study investigating the safety, tolerability, and preliminary efficacy of IBC -Ab001, a no vel immunomodulatory agent designed to harness peripheral immunity by targeting the inhibitory immune checkpoint PD -L1 in patients with early AD. IBC-01-01 adopts an innovative approach in AD treatment by targeting an immune checkpoint inhibitor for the fir st time in dementia therapy. This first -of-its-kind treatment represents a unique approach to targeting AD by leveraging the physiological role of the immune system in brain repair."

Checkpoint inhibition • Clinical • IO biomarker • P1 data • Alzheimer's Disease • CNS Disorders • Dementia • Inflammation • Oncology • APOE

First-in-Human Phase 0 Study of AB001, a Prostate-Specific Membrane Antigen-Targeted 212Pb Radioligand, in Patients with Metastatic Castration-Resistant Prostate Cancer. (PubMed, J Nucl Med) - "γ-camera imaging of AB001 was feasible, even at a microdose, and demonstrated metastatic targeting, albeit for only 1 lesion. The promising biodistribution and clearance encourage further clinical investigation."

Journal • P1 data • Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • FOLH1