atorvastatin / Generic mfg. - LARVOL DELTA

EFFECT OF ATORVASTATIN ON CLINIMETRIC OUTCOMES OF PATIENTS WITH RHEUMATOID ARTHRITIS AND DYSLIPIDEMIA (EULAR 2025) - "Our results indicated that high doses of statins can significantly reduce the DAS28 ESR score, suggesting attenuation of RA activity. Dyslipidemia and chronic inflammation are interrelated and collectively increase the risk of cardiovascular diseases significantly in patients with autoimmune diseases like rheumatoid arthritis. Proper management of both factors is essential to improve the overall health of these patients."

Clinical • Cardiovascular • Diabetes • Dyslipidemia • Endocrine Disorders • Hypertension • Immunology • Inflammation • Inflammatory Arthritis • Metabolic Disorders • Rheumatoid Arthritis • Rheumatology • Type 2 Diabetes Mellitus

MULTI-TARGET THERAPY IN PREVENTION OF STEROID-INDUCED OSTEONECROSIS: A RANDOMIZED CONTROLLED CLINICAL TRIAL. PRELIMINARY REPORT (EULAR 2025) - "The intervention group was administered a daily dosage of atorvastatin (40 mg), Aspirin (80 mg), and vitamin E (400 mg), along with a weekly dose of alendronate (70 mg). The initial findings suggest that a multi-target therapy could potentially prove effective in both preventing and mitigating steroid-induced osteonecrosis. While the multi-target therapy demonstrated a trend toward reducing the incidence of steroid-induced osteonecrosis, this observation did not reach statistical significance."

Clinical • Metabolic Disorders

ARE MYOSITIS ANTIBODIES MORE COMMON THAN WE KNOW – VERY HIGH PREVALENCE OF ANTI-HMGCR ANTIBODY IN A SINGLE-CENTRE UK COHORT (EULAR 2025) - "One patient was on Rosuvastatin at diagnosis and had received Atorvastatin and Simvastatin in the past. In our cohort, the proportion of patients with MSA/MAA was higher than what was previously reported in the literature. Notably, the proportion of patients with anti-HMGCR was much higher than in previous studies and was found in almost a quarter of patients. All patients with anti-HMGCR antibody had a history of statin use."

Clinical • Dermatomyositis • Immunology • Inflammation • Myositis • Rheumatology • DDB1 • IFIH1

Low Vitamin D Status Attenuates Hypolipidemic and Pleiotropic Effects of Atorvastatin in Women. (PubMed, Nutrients) - "In group I, atorvastatin treatment was associated with an increase in HOMA-IR, glycated hemoglobin, and creatine kinase. Low vitamin D status may exert an unfavorable effect on the lipid-dependent and lipid-independent effects of atorvastatin in middle-aged or elderly women."

Biomarker • Journal • Atherosclerosis • Dyslipidemia • Metabolic Disorders • CRP

Comparative Efficacy of Atorvastatin and Placebo in Intensive Care Unit Patients with Coronavirus Disease 2019: A Randomized Controlled Trial. (PubMed, J Res Pharm Pract) - "Atorvastatin could effectively reduce inflammation in intensive care unit (ICU) patients admitted for COVID-19 management, but it could not influence the clinical outcomes. We suggested investigating its effect on COVID-19 in larger sample sizes, nonICU patients, and from the beginning of the diagnosis for a longer duration."

Journal • Critical care • Infectious Disease • Inflammation • Novel Coronavirus Disease • Respiratory Diseases • CRP • IL6

The Activity of Phytotherapic Extracts Combined in a Unique Formulation Alleviates Oxidative Stress and Protects Mitochondria Against Atorvastatin-Induced Cardiomyopathy. (PubMed, Int J Mol Sci) - "The purpose of this study was to evaluate the effects of a novel phytotherapic formulation (PF) composed of Curcuma and Boswellia essential oils, Harpagophytum procumbens root, and Bromelain on the human AC16 cell line in an in vitro model of atorvastatin-induced cardiomyopathy. Interestingly, supplementation of cells with PF reduced oxidative stress by 20%, improved mitochondrial reshape and function, and restored the expression of the Nrf2/HO-1/GPX4 axis. These results provide new insights into statin-induced cardiomyopathy and suggest the employment of PF as a promising agent in the recovery of cardiac function."

Journal • Cardiomyopathy • Cardiovascular • Myositis • GPX4

Shoulder Tendinopathy Induced by Statins: A Case Report and Systematic Review. (PubMed, J Pers Med) - "The case report describes a patient who experienced RCD after increasing atorvastatin dosage, with symptoms improving after dose reduction and a multimodal personalized IRP...Further research is needed to clarify the relationship between statins and shoulder tendinopathy. Early diagnosis and appropriate personalized management are crucial for optimizing patient outcomes."

Journal • Musculoskeletal Diseases

A Study to Learn How the Study Medicine Danuglipron is Taken Up Into the Blood and If Danuglipron Changes How the Body Processes Other Study Medicines (Atorvastatin and Rosuvastatin) in Healthy Adults Who Are Overweight or Obese (clinicaltrials.gov) - P1 | N=82 | Completed | Sponsor: Pfizer | Active, not recruiting ➔ Completed

Trial completion • Genetic Disorders • Obesity

Combined phototherapy and systemic treatments for non-segmental vitiligo from 2013 to 2023: A systematic review (SID 2025) - "Interventions included: psoralen (2), afamelanotide, apremilast, minocycline, vitamin D, atorvastatin, vitamin A and E, and prednisone. In conclusion, UVB remains efficacious in the treatment of vitiligo and some systemic therapies further improved VASI scores. In agreement with previous studies, combination therapy is superior to monotherapy."

Review • Dermatology • Immunology • Vitiligo

LABS DO LIE: The Case of the Missing Bicarbonate (ATS 2025) - "Treatment included metformin 1000 mg and glipizide 10 mg daily for glycemic control, and atorvastatin 20 mg with fenofibrate 145 mg daily to manage lipid levels. This case highlights the diagnostic challenge of pseudo-anion gap metabolic acidosis in severe hypertriglyceridemia. Discrepancies between serum chemistry and ABG values should raise suspicion of lab interference, especially in patients with hypertriglyceridemia risk factors. Accurate diagnosis and management rely on correlating clinical findings with ABG, serum chemistry, and lipid panels, as shown in this case, where treating hypertriglyceridemia improved outcomes."

Clinical • Cardiovascular • Diabetes • Dyslipidemia • Hypertension • Hypertriglyceridemia • Metabolic Disorders • Severe Hypertriglyceridemia

Acute Respiratory Failure Secondary to Statin-induced Anti-HMG CoA Reductase Myopathy: A Rare Complication With Diagnostic Challenges (ATS 2025) - "Her symptoms began a month after starting atorvastatin following a cardiac catheterization...Invasive ventilation should only be pursued if confirmed by arterial blood gas and non-invasive measures are contraindicated, as NIF and VC alone may be unreliable indicators. This case emphasizes the need for a comprehensive approach to ARF with consideration of autoimmune myopathies in the differential."

Acute Respiratory Distress Syndrome • Cardiovascular • Chronic Obstructive Pulmonary Disease • CNS Disorders • Congestive Heart Failure • Coronary Artery Disease • Dyslipidemia • Gastrointestinal Disorder • Heart Failure • Hypertension • Infectious Disease • Interstitial Lung Disease • Myasthenia Gravis • Myositis • Pneumonia • Pulmonary Disease • Respiratory Diseases

From Atypical Symptoms to Diagnosis: A Case of Type 2B Spontaneous Coronary Artery Dissection (ATS 2025) - "The patient was diagnosed with type 2B SCAD, with no coronary intervention performed, and subsequently discharged on dual antiplatelet therapy, metoprolol, and atorvastatin...Additionally, these patients require counselling on the risks of recurrent SCAD and persistent chest pain, among other concerns. A high index of suspicion should be maintained, especially in this demographic, to initiate timely treatment and avert mortality."

Clinical • Acute Coronary Syndrome • Atherosclerosis • Coronary Artery Disease • Dyslipidemia • Hypertension • Myocardial Infarction • Obstructive Sleep Apnea • Pain • Respiratory Diseases • Sleep Disorder

Atypical Presentation of Takotsubu Cardiomyopathy in an Elderly Patient (ATS 2025) - "The patient was loaded with Aspirin and Atorvastatin and started on a heparin drip...Reports of Takotsubo Cardiomyopathy in elderly dementia patients remain sparse in the literature. This case contributes to an emerging, yet understudied, subset of Takotsubo Cardiomyopathy cases in dementia patients, emphasizing the need for further exploration in this unique population."

Clinical • Acute Coronary Syndrome • Alzheimer's Disease • Cardiomyopathy • Cardiovascular • CNS Disorders • Coronary Artery Disease • Dementia • Dermatology • Dyslipidemia • Endocrine Disorders • Heart Failure • Immunology • Metabolic Disorders • Myocardial Infarction • Sjogren's Syndrome • Urticaria

Stroke in the Context of HIV Vasculopathy and Varicella Zoster Virus Infection: A Case Report (ATS 2025) - "The patient was started on aspirin, clopidogrel, and atorvastatin. Brain imaging typically reveals ischemic or hemorrhagic infarctions, with lesions present in both the superficial and deep gray-white matter junctions. Given the severity of VZV-associated vasculopathy, it is essential to consider this condition in the differential diagnosis."

Case report • Clinical • Ataxia • Atherosclerosis • Cardiovascular • CNS Disorders • Hematological Disorders • Herpes Zoster • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Movement Disorders • Pain • Thrombosis • Varicella Zoster • Vasculitis • CD4

Comparative Studies of GAC Metric Tools AGREE, Analytical Eco-Scale, BAGI and WAC RGB Model to Determine Atorvastatin in Pharmaceuticals. (PubMed, Crit Rev Anal Chem) - "The results demonstrate that applying multiple assessment tools to evaluate the analytical method's greenness and whiteness is highly effective in acquiring synergetic results and enhancing the understanding of the GAC and WAC principles. These studies could help researchers and academicians to develop new environment-friendly methods to quantify atorvastatin in pharmaceuticals and biological fluids."

Journal • Review • Dyslipidemia

Effects of high doses of statins to prevent contrast-induced acute kidney injury, based on cystatin C levels: A meta-analysis. (PubMed, Sci Prog) - "This systematic review with meta-analysis was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under protocol (CRD42023441815).ResultsWe included four studies with a total of 1167 patients, of whom 594 (50.8%) received high-dose statins (atorvastatin or rosuvastatin). Overall, high doses of statins were associated with a lower incidence the CIAKI (OR 0.31; 95% CI [0.19,0.53]; P < .0001).ConclusionOur findings suggest that high doses of statins may play an important role as a measure to prevent CIAKI. If this result is confirmed, we will be able to set up CIAKI prevention protocols, thus expanding the number of patients who will undergo contrast-enhanced exams."

Biomarker • Clinical • Journal • Retrospective data • Review • Acute Kidney Injury • Cardiovascular • Diabetes • Dyslipidemia • Hypertension • Metabolic Disorders • Nephrology • Renal Disease • CST3

Ecofriendly first-derivative synchronous fluorometric method for simultaneous determination of atorvastatin and aspirin in pharmaceutical preparations. (PubMed, Sci Rep) - "The results confirmed its minimal environmental impact and eco-friendly nature. The FDSSF method provides a green, accurate, and reliable approach for simultaneously determining ATO and ASP in pharmaceuticals, offering high sensitivity, exceptional selectivity, and environmental sustainability."

Journal • Atherosclerosis • Cardiovascular • Myocardial Infarction

Rhabdomyolysis Due to Interactions Between CDK4/6 Inhibitors and Statins During Breast Cancer Treatment: A Case-Based Systematic Review (BBCS 2025) - "All patients were treated for metastatic breast cancer with CDK4/6 inhibitors (ribociclib or palbociclib) alongside statins (simvastatin, atorvastatin, or rosuvastatin). Rhabdomyolysis due to CDK4/6 inhibitor–statin interactions is a rare complication, albeit with a potentially life-threatening risk. Monitoring, prompt intervention, and individualized treatment strategies are paramount for preventing complications and improving patient outcomes."

Clinical • Review • Acute Kidney Injury • Breast Cancer • HER2 Breast Cancer • HER2 Negative Breast Cancer • HER2 Positive Breast Cancer • Hormone Receptor Breast Cancer • Hormone Receptor Positive Breast Cancer • Musculoskeletal Pain • Nephrology • Oncology • Pain • Renal Disease • Solid Tumor • HER-2

Rethinking statin therapy in nonagenarians with acute coronary syndrome (HEART FAILURE 2025) - "High-intensity statin therapy was defined as atorvastatin doses ≥40 mg/day or rosuvastatin ≥20 mg/day... In this cohort of elderly patients with ACS, high-intensity statin therapy did not demonstrate significant advantage over non-high-intensity in reducing MACE during the two-year follow-up. These findings suggest that the intensity of statin therapy may have limited impact on long-term outcomes in this population, highlighting the need for individualized treatment approaches considering frailty and comorbidities. Further research is warranted to clarify the role of statin intensity in this underrepresented age group."

Acute Coronary Syndrome • Cardiovascular • Congestive Heart Failure • Dyslipidemia • Heart Failure • Hypertension • Ischemic stroke

The effect of homocysteine correction on the quality of life in CKD patients (ERA 2025) - "The study established the positive effect of atorvastatin on the quality of life of patients with CKD. Its complex use in the treatment of CKD is recommended as an additional drug to improve the homocysteine index, which is also associated with the electrolyte balance in CKD."

Clinical • HEOR • Chronic Kidney Disease • Metabolic Disorders • Nephrology • Pain

Hepatitis, acute kidney injury and myositis due to atorvastatin (ERA 2025) - "Our patient showed a rare case of hepatitis, myositis and acute kidney injury after introduction of atorvastatin. As we know, this is the first case of acute kidney injury caused by statins with a delay of elevation of creatinin kinase. It shows the necessity to monitor the patients after introduction of statins to prevent the occurrence of side effect, although generally minor, but in some cases lead to major medical conditions."

Acute Kidney Injury • Addiction (Opioid and Alcohol) • Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Dyslipidemia • Hepatology • Hypertension • Immunology • Inflammation • Metabolic Disorders • Myocardial Infarction • Myositis • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

Pharmacogenetic analysis from exome data and pharmaco-clinico-biological co-interpretation enable personalized care in nephrology and kidney transplantation (ERA 2025) - "Relevant drugs affected by altered metabolism included tacrolimus (9/19), azathioprine (1/19), tramadol (6/19), clopidogrel (7/19), allopurinol (3/19), atorvastatin (5/19). Pharmacogenetic analysis based on exome data is valuable for managing patients with chronic kidney disease, as it can prevent adverse effects in these polymedicated patients. It is also particularly beneficial for patients with forthcoming immunosuppressive therapy for kidney transplantation."

Biomarker • Chronic Kidney Disease • Nephrology • Transplantation • HLA-B

Evaluation of Rosuvastatin Use and Its Association with Proteinuria and Kidney Function Impairment in Kidney Transplant Recipients (ERA 2025) - "In this extensive and representative sample of kidney transplant recipients, no association was identified between rosuvastatin use and impaired renal function or higher proteinuria levels compared to atorvastatin after 12 months of treatment. These findings suggest that rosuvastatin appears to be a safe option from a renal perspective in the kidney transplant population. However, further studies with broader methodological designs are recommended to explore in greater detail aspects that were not addressed in the present study, including long-term safety and potential metabolic effects."

Clinical • Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Dyslipidemia • Hypertension • Metabolic Disorders • Nephrology • Renal Disease • Transplantation • KEAP1

Successful Use of Glucagon-Like Peptide-1 Receptor Agonists (GLP1-RA) in A Patient WITH OBESITY and DIABETIC KIDNEY DISEASE UNDER Peritoneal Dialysis: a Case Report (ERA 2025) - "The patient was treated with insulin 43 U/day (18 U Aspart and 25 U Degludec), along with furosemide 250 mg, amlodipine 10 mg, eplerenone 50 mg, bisoprolol 2.5 mg/day, clopidogrel/aspirin 70/100 mg, omega−3 fatty acids 3000 mg and atorvastatin 40 mg (figure 1). In conclusion, GLP1-RAs may help improve metabolic control in patients with obesity and diabetes treated by PD potentially making kidney transplantation feasible. GLP1-RAs is well tolerated, though a careful monitoring is required."

Case report • Clinical • Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Genetic Disorders • Nephrology • Obesity • Renal Disease • Type 2 Diabetes Mellitus

Not Just an Itch: A Rare Dermatological Manifestation in Chronic Kidney Disease (ERA 2025) - "Her medical history includes long-standing hypertension treated with irbesartan, a surgically and endovascularly managed cerebral aneurysm in 2006, and a history of preeclampsia and HELLP syndrome during pregnancies (G5P5)...Current medications include esomeprazole, acetylsalicylic acid, sertraline, epoetin beta, folic acid, sevelamer, cinacalcet, cholecalciferol, calcitriol, and lactulose...The onset of the lesions coincided with the initiation of atorvastatin therapy, which was discontinued without clinical improvement...Treatment was started with acitretin 10 mg, allopurinol 100 mg, and emollients, resulting in initial improvement... This case underscores the importance of recognizing RPC as a rare but clinically significant skin disorder, particularly in patients with systemic illnesses like CKD. While uncommon, its association with systemic diseases highlights the need for a multidisciplinary approach. After excluding potential drug-induced causes, a skin biopsy..."

Autosomal Dominant Polycystic Kidney Disease • Cardiovascular • Chronic Kidney Disease • Dermatology • Diabetes • Diabetic Nephropathy • Genetic Disorders • Gynecology • Hypertension • Metabolic Disorders • Mood Disorders • Nephrology • Oncology • Polycystic Kidney Disease • Pruritus • Renal Disease • Vascular Neurology