AngioCal (40 kDA PEGylated anticalin) / Palvella Therapeutics - LARVOL DELTA

Evaluating a calcium chloride-elastase combination for creating large aneurysms in the endovascular rabbit elastase model. (PubMed, Interv Neuroradiol) - "Aneurysm volumes were estimated using AngioCalc.com...Differences in width (4.1 ± 0.92 mm vs 3.4 ± 0.36 mm; p = 0.06), height (9.0 ± 1.1 mm vs 9.1 ± 2.1 mm; p = 0.46), and volume (83.5 ± 38.35 mm³ vs 53.0 ± 16.94 mm³; p = 0.11) were not significant between CaCl2 + elastase and elastase-alone, respectively.ConclusionsCaCl2 modestly increased neck size but did not significantly enlarge overall aneurysm dimensions. Further studies are needed to assess its utility in endovascular aneurysm models."

Journal • Preclinical • Cardiovascular • ELANE

EFFECTS OF THE ANEURYSM TREATMENT METHOD ON COIL PACKING DENSITY AND ITS RELATIONSHIP WITH THE OSTIUM AREA. (PubMed, J Vasc Interv Radiol) - "In cerebral aneurysms treated with balloon- or stent-assisted coiling, the CPD value does not differ from that in aneurysms treated with simple coiling."

Journal • Cardiovascular • Immunology • Vascular Neurology

"What's the silent @Roche $PIRS project aimed &I/O just as Avastin comes off patent $AMGN attacking? Antiangio now required? Ramp PRS-050 up?"

Biosimilar

Nonclinical pharmacokinetics and safety of Angiocal, the first VEGF-A-specific alternative scaffold protein entering clinical development for cancer (AACR 2011) -

Effects on inflammatory cytokines or complement factors was not reported; Exaggerated pharmacodynamic effects consistent with potent VEGF neutralization were seen

Pharmacokinetic data • Oncology