ampicillin / Generic mfg. - LARVOL DELTA

Positive Syphilis Serology With Concurrent Disseminated Talaromycosis marneffei in a Patient With HIV: A Case Report. (PubMed, Am J Case Rep) - "However, his symptoms did not improve after ampicillin treatment...It is essential to ensure an adequate duration of antifungal therapy and conduct a comprehensive post-treatment evaluation, as the current evidence is only derived from single cases. The use of blood culture positivity as a marker for treatment response still requires further validation with a larger number of cases."

Journal • Cough • Dermatology • Human Immunodeficiency Virus • Infectious Disease • Respiratory Diseases

Transcriptional analysis of D, D-carboxypeptidase genes as secondary cephalosporin resistance reporters in Escherichia coli harbouring blaCTX-M. (PubMed, FEMS Microbiol Lett) - "MIC determination, growth assessment, and qRT-PCR were performed under ampicillin and oxyimino cephalosporins stress...The study revealed consistent upregulation of dacB and dacD with host-specific effects on MICs, highlighting their potential as reporters for cephalosporin resistance in future diagnostics. Differential transcriptional responses observed among recombinant strains further suggested host-specific adaptive mechanisms during antibiotic exposure."

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Multidrug-resistant CC3 Staphylococcus haemolyticus with increased vancomycin MIC among neonates in a Brazilian NICU. (PubMed, Diagn Microbiol Infect Dis) - "Colonization rates were similar between periods (71.2% vs. 67.3%; p=0.57), with no clinical or microbiological differences, except for reduced ampicillin-gentamicin use in the second period (p=0.048). The epidemic ST29 lineage, subsequently associated with neonatal outbreaks in Europe, was already circulating in our NICU between 2019 and 2021. These findings highlight the need for enhanced surveillance of S. haemolyticus in neonatal settings."

Journal • Critical care • Infectious Disease • Novel Coronavirus Disease

Staphylococcal-scalded skin syndrome in an adult with acquired epidermolysis bullosa mimicking pemphigus presentation (EADV 2026) - "The patient was initially treated with high-dose oral prednisone (1 mg/kg/day) and careful wound care, including topical emollients and antiseptic dressings for the extensive mucocutaneous erosions. Intravenous ampicillin (50 mg/kg per day, divided into three doses) was administered...Dermatologists should be aware of this complication, especially in the presence of superficial erosions and a positive Nikolsky sign. A quick and accurate diagnosis and treatment of this complication are mandatory to prevent widespread illness and death."

Clinical • CNS Disorders • Dermatopathology • Immunology • Infectious Disease • Mood Disorders • Movement Disorders • Ophthalmology • Parkinson's Disease • Pemphigus Vulgaris • Steven-Johnson Syndrome

Structural and functional characterization of PDC-16 β-lactamase reveals a constrained active-site architecture associated with altered catalysis. (PubMed, Int J Biol Macromol) - "Consistent with these structural features, kinetic analyses revealed reduced catalytic efficiency toward ampicillin and carbapenems, while activity toward cefotaxime was comparatively preserved, indicating substrate-dependent effects associated with the constrained active-site architecture. Biochemical assays showed that avibactam produced substantially greater inhibition of PDC-16 than representative phenazine-derived compounds, underscoring that favorable computational binding does not necessarily translate into inhibitory efficacy. Together, these findings support an association between the remodeled active-site architecture and substrate-dependent catalytic behavior in PDC-16."

Journal

Beyond simple folliculitis.lupus folliculitis in a male patient:A diagnostic dilemma (EADV 2026) - "The patient had failed multiple topical and systemic treatments, including antibiotics(metronidazole,ampicillin,azithromycin,clindamycin,doxycycline) and retinoids(oral and topical isotretinoin) for treating acne rosacea and folliculitis.Cutaneous examination revealed hyperpigmentation involving his malar(butterfly) region,multiple milia on zygomatic region,fine wrinkles in periocular region,there were multiple erythematous plaques studded with pustules distributed asymmetrically in his beared area of face and neck,with few areas of scarring,however no such lesion was present on his scalp,and his mucosae were healthy looking.All laboratory parameters were noramal including ANA and anti dsDNA.skin biopsy done for histopathological evaluation showed acanthosis with slight hyperkeratosis along with follicular plugging.upper dermis showed solar elastosis along with dense lymphocytic infiltrate no neutrophils or eosinophils were seen,lymphocytic aggregates were seen around..."

Clinical • Acne Vulgaris • Cutaneous Lupus Erythematosus • Immunology • Inflammatory Arthritis • Lupus • Rosacea

The impact of EmrA deficiency on antibiotic-susceptibility and virulence- and stone-associated phenotypes in Proteus mirabilis. (PubMed, Front Microbiol) - "Comparison of the WT and ΔemrA strains showed that emrA deletion was associated with decreased MICs for carbenicillin and ampicillin, whereas the susceptibilities to most other antibiotics remained unchanged...This study identifies associations between emrA deletion and susceptibility changes to selected antibiotics, altered stress responses, and enhanced virulence- and stone-associated phenotypes in P. mirabilis. Because MICs were not measured for the complemented strain, the specific contribution of EmrA to the antibiotic-susceptibility phenotype remains unresolved."

Journal • Infectious Disease • Nephrology

Interfacial mechanisms governing the transport of bacteria in Yellow River sediments: Impact of antibiotic exposure and resistance phenotypes. (PubMed, J Hazard Mater) - "Under ampicillin stress (corresponding resistance of ARB), ASB exhibited a higher intracellular ATP levels (reaching ∼3.0 RLU) that fuelled motility and transport. Moreover, elevated levofloxacin (no corresponding resistance of ARB) stress induces the hypersecretion of EPS, thereby enhancing adhesion and effectively constraining transport. Our findings demonstrate that bacterial transport in complex sediments is dictated by the interplay between metabolically driven motility and interfacial retention, underscoring the critical need to integrate microbial metabolic states into predictive models of antimicrobial resistance dissemination."

Journal • CNS Disorders • Psychiatry

Genotypic and phenotypic analysis of antimicrobial resistance in Salmonella enterica isolates from retail chicken products in Kuwait. (PubMed, Poult Sci) - "Phenotypically, resistance was higher to ampicillin, tetracycline and cefotaxime with rates of 97.1%, 95.7% and 89.9%, respectively...The agreement between the genetic and phenotypic data varied, however, concordance was high for tetracycline (95.5%; k = 0.02), gentamicin (79.7%; k = 0.43), chloramphenicol (78.3%; k = 0.35) and meropenem (100%; k = 1.0), whereas, cefotaxime (10.1%; k = 0.0) and nalidixic acid (30.4%; k = 0.0) showed poor agreement...In conclusion, the widespread multidrug resistance and high load of resistance genes detected in Salmonella from retail chicken in Kuwait point to an important food safety concern. The findings support the need for routine surveillance in Kuwait that combines whole-genome sequencing with conventional susceptibility testing as a part of a broader One Health approach."

Journal • Infectious Disease

Integrated microbiome and metabolome analysis insights into microbial roles in poplar wetwood formation and control. (PubMed, Pest Manag Sci) - "The formation of poplar wetwood in Jianghan Plain involves the action of various microorganisms."

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Design of a yeast-based bio-interface on an optical fiber SPR platform toward drug adsorption monitoring. (PubMed, Beilstein J Nanotechnol) - "Using this sensor, real-time adsorption of pharmaceuticals onto yeast cells was evaluated: Doxorubicin showed a concentration-dependent SPR response, whereas ampicillin showed no significant change in SPR response. The optical fiber configuration allows for direct immersion into environmental waters for in situ measurements, providing a platform for dynamic analysis of microorganism-pollutant interactions and advancing water treatment and environmental monitoring technologies."

Journal

Synergistic activity of Ginsenoside Rh2 with β-lactam antibiotics and its mechanism of action against methicillin-resistant Staphylococcus aureus. (PubMed, Microbiol Spectr) - "Checkerboard assays revealed that G-Rh2 and β-lactam antibiotics (cefoxitin, cefazolin, ampicillin, and meropenem) exhibit a synergistic antibacterial effect on MRSA. Moreover, G-Rh2 significantly delays the development of antibiotic resistance. These findings provide a promising new strategy for using natural products to combat antibiotic-resistant infections, which may extend the lifespan of existing antibiotics and improve the treatment outcomes for patients."

Journal • Infectious Disease

Risk Factors Associated With Multidrug Resistant Organism (MDRO) Isolates in Infected Diabetic Foot Ulcers (DFU): An Analytical Cross-sectional Study. (PubMed, J ASEAN Fed Endocr Soc) - "For gram-negative isolates, erythromycin had the most resistance at 17.53% followed by oxacillin and clindamycin both at 13.4%. For gram-positive isolates, highest resistance were seen with ampicillin at 18.99% followed by cefuroxime at 13.57% and amoxicillin-clavulanate at 11.63%.Higher ulcer grade (Crude OR = 1.11 [95% CI 1.00 - 1.23], p-value 0.04; Crude OR = 1.29, [95% CI 1.04 - 1.60], p-value 0.02), as well as previous admission for diabetic foot ulcer (Crude OR = 2.28, [95% CI 1.10 to 4.73], p-value 0.04) were associated with multidrug resistance...There is a high burden of multidrug resistant organism infection in diabetic foot ulcers with significant association in higher ulcer grades. A previous admission for diabetic foot ulcer significantly increases the odds for MDRO infection in succeeding diabetic foot infections."

Journal • Observational data • Retrospective data • Infectious Disease • Pneumonia

A Novel Nanoantibiotic Formulation With Magnetic and Targeting Potential: Ampicillin-Conjugated L-glu-Fe3O4 NPs. (PubMed, Microbiologyopen) - "This is the first report on the use of l-glu as a surface modifier of Fe3O4 NPs and Amp. Use of l-glu increases the drug-carrying capacity of NPs and reduces the possible side effects of Amp."

Journal

Inappropriate Antimicrobial Regimen Leading to Recurrent Listeria monocytogenes Meningitis: A PK/PD-Based Case Analysis and a Literature Review. (PubMed, Infect Drug Resist) - "Furthermore, a review of 43 published case reports has demonstrated that ampicillin in combination with gentamicin remains the first-line therapy for L. monocytogenes meningitis. Selection of antimicrobial therapy for L. monocytogenes meningitis should be guided by pharmacokinetic principles. Individualized precision therapy based on lesion-site PK/PD characteristics is essential to improve treatment success and patient prognosis."

Journal • PK/PD data • CNS Disorders • Infectious Disease

Comparative genomic and phenotypic profiling of commercial probiotic Enterococcus faecium strains: insights into safety and functional attributes. (PubMed, World J Microbiol Biotechnol) - "Crucially, all probiotic strains lacked high-risk antibiotic resistance genes (vanA) and major virulence determinants (esp, hyl, gelE) found in the clinical control strain ATCC 51559, and were phenotypically susceptible to the tested β-lactams (penicillin, ampicillin), vancomycin, and tetracycline, and lacked acquired resistance genes for WHO-defined critically important antibiotics. Our integrated analysis indicates a strong link between genomic identity, functional potential, and safety profile in commercial E. faecium probiotics. This study provides a detailed genomic framework for strain-level safety assessment and supports the informed selection of E. faecium strains for probiotic applications."

Clinical • Journal

ANTIBIOTIC PRE-CONDITIONING FOR FECAL MICROBIOTA TRANSPLANTATION DOES NOT IMPAIR GUT BARRIER INTEGRITY IN MICE (UEGW 2026) - "Concentrations were: ampicillin, gentamicin, and metronidazole at 0.25 mg/day, and vancomycin at 0.125 mg/day. The antibiotic concentrations tested appeared safe and did not alter intestinal barrier integrity. Ongoing analyses will clarify how pre-conditioning influences microbiota engraftment following FMT."

Preclinical • Transplantation • TJP1

LONG-TERM RIFAXIMIN USE IS ASSOCIATED WITH INCREASED ANTIMICROBIAL RESISTANCE AND ESBL-PRODUCING ORGANISMS IN DECOMPENSATED CIRRHOSIS PATIENTS WITH FIRST-EPISODE SPONTANEOUS BACTERIAL PERITONITIS (UEGW 2026) - "ESBL-producing organisms were more frequent (34.2% vs 18.4%, p=0.047), as was resistance to ceftriaxone (34.2% vs 18.4%, p=0.047). Increased resistance was also observed for ciprofloxacin (46.9% vs 21.1%, p=0.007), ampicillin (68.0% vs 39.7%, p=0.016), and amoxicillin-clavulanate (31.6% vs 8.6%, p=0.040).Subgroup analysis by cirrhosis etiology showed that this association was most pronounced in patients with cryptogenic cirrhosis (p=0.048). Long-term rifaximin use is associated with increased antimicrobial resistance and ESBL-producing organisms in patients with decompensated cirrhosis and first-episode SBP, without changes in pathogen distribution. These findings support a more selective use of rifaximin and highlight the importance of balancing its clinical benefits against the potential risk of promoting antimicrobial resistance."

Clinical • CNS Disorders • Fibrosis • Hepatic Encephalopathy • Hepatology • Immunology • Infectious Disease • Liver Cirrhosis

Increased Prevalence of Multidrug-Resistant Escherichia coli as an Adverse Effect of Excessive Antibiotic Use in a Tertiary Care Hospital in Serbia. (PubMed, Life (Basel)) - "Total antibiotic consumption remained stable, with no correlation between consumption and MDR isolation rates, although ampicillin resistance increased significantly. Compared with 2015, resistance significantly increased to amoxicillin-clavulanic acid, cefotaxime, cefepime, ceftazidime, ciprofloxacin, and levofloxacin, while ceftriaxone resistance decreased. The blaCTX-M gene was detected in 53% of bloodstream isolates, indicating widespread dissemination of ESBL-producing E. coli and highlighting the need for continuous surveillance and antimicrobial stewardship."

Adverse events • Journal • Infectious Disease

Phenotypic Characterisation of Uropathogenic Escherichia coli: Virulence Factors, ESBL Production, and Antibiogram in a Tertiary Care Hospital in Bihar. (PubMed, Cureus) - "High resistance rates to ampicillin and co-trimoxazole were noted. Nitrofurantoin and gentamicin retained better activity...Nitrofurantoin and aminoglycosides remain useful therapeutic options. Routine characterisation of UPEC is essential for effective UTI management in this region."

Journal • Infectious Disease • Nephrology

Occurrence and Antimicrobial Resistance Profiles of Culturable Ampicillin-Resistant Gram-Negative Bacteria in the Ring of Cenotes Aquifer, Yucatán, Mexico. (PubMed, Microorganisms) - "Resistance to cefotaxime, levofloxacin, gentamicin, and tetracycline was detected among several bacterial genera. Genomic analysis of 19 E. coli isolates revealed resistance determinants associated with multiple antimicrobial classes and a diverse population structure dominated by phylogroup B1. These findings show that the Ring of Cenotes aquifer harbors diverse populations of culturable ampicillin-resistant Gram-negative bacteria and emphasize the importance of groundwater ecosystems as environmental reservoirs of AMR."

Journal • Infectious Disease • Pneumonia

Isoflavones with Multifaceted Activities Synergistically Sensitize Pseudomonas aeruginosa to Antibiotics In Vitro and In Vivo. (PubMed, Antibiotics (Basel)) - "In addition, daidzein and genistein were found to synergistically sensitize the wild-type P. aeruginosa strain to gentamicin, carbenicillin, tobramycin, ampicillin, and polymyxin B, and synergistically or partially synergistically sensitize a multidrug-resistant strain to gentamicin, tobramycin, and ampicillin. Furthermore, in host macrophages, daidzein and genistein significantly inhibited LPS-induced production of NO, IL-6, and IL-1β when combined with an RXR agonist, implying a protective effect on host tissues through PPAR-γ activation. These findings demonstrate that daidzein and genistein serve as effective adjuncts to conventional antibiotics, exerting multifaceted actions against P. aeruginosa infection."

Journal • Preclinical • Infectious Disease • Inflammation • IL1B • IL6

Clinical Characteristics and Antimicrobial Resistance Profiles of Pediatric Enterococcal Infections: A Comparison Between Enterococcus faecium and Enterococcus faecalis. (PubMed, Pathogens) - "faecium showed substantially greater resistance to ampicillin and penicillin. Pediatric E. faecium and E. faecalis infections differed in patient profiles, healthcare exposures, antimicrobial susceptibility, and disease burden. Species identification may support clinical assessment and antimicrobial stewardship."

Clinical • Journal • Retrospective data • Hematological Disorders • Hematological Malignancies • Infectious Disease • Oncology • Pediatrics • Septic Shock

Genomic Epidemiology, Antimicrobial Resistance, and Virulence of Clinical Enterococcus Isolates from Hat Yai, Thailand: Genomic Relatedness and Lineage Persistence. (PubMed, Antibiotics (Basel)) - " All isolates were susceptible to linezolid and oritavancin, whereas non-susceptibility to ampicillin, fosfomycin, vancomycin, and daptomycin was 60.0%, 57.5%, 12.5%, and 5.0%, respectively. High-level gentamicin resistance and MDR occurred in 37.5% and 22.5%, respectively...Three novel STs were identified, with E. faecium ST3096 exhibiting high-level ampicillin resistance, fosfomycin resistance, and reduced daptomycin susceptibility. These findings reveal emerging resistant lineages and spatiotemporal patterns of genomic relatedness, supporting continued genomic surveillance of clinical enterococci in Thailand."

Journal • Infectious Disease • LIAS

Isolation and Preliminary In Vitro Characterization of a Honey-Derived Bacillus licheniformis Isolate. (PubMed, Antibiotics (Basel)) - " In vitro assays revealed that Blhoney exhibits robust tolerance to simulated gastrointestinal stress, including extreme acidity (pH 1-3), bile salts (0.3-1%), pepsin, and pancreatin, maintaining viability for up to 24 h. Phenotypic antimicrobial testing demonstrated measurable inhibition zones for erythromycin, kanamycin, chloramphenicol, ampicillin, tetracycline, gentamicin, streptomycin, and spectinomycin, whereas no measurable inhibition zones were observed for penicillin G, rifampicin, ciprofloxacin, or ceftazidime. Overall, these findings indicate that the honey-derived Blhoney isolate exhibits preliminary probiotic-associated characteristics under the tested in vitro conditions. However, further strain-level genomic and safety characterization is required before its potential probiotic application can be established."

Journal • Preclinical