ampicillin / Generic mfg. - LARVOL DELTA

Chitosan/Carboxymethyl Cellulose Nanocomposites Prepared via Electrolyte Gelation-Spray Drying for Controlled Ampicillin Delivery and Enhanced Antibacterial Activity. (PubMed, Polymers (Basel)) - "The nanocomposites demonstrated controlled ampicillin release and pronounced antibacterial activity against Staphylococcus aureus, with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 3.2 µg/mL and 5.3 µg/mL, respectively, which were lower than those of free ampicillin. These results indicate that the chitosan/carboxymethyl cellulose nanocomposites are promising, eco-friendly carriers for antibiotic delivery and antibacterial applications."

Journal

Synthesis, Antimicrobial Activity and Cytotoxicity of Novel (Piperidin-4-yl)adamantane-1-carboxylate N-Substituted Derivatives. (PubMed, Molecules) - "It was found that the synthesized substituted piperidines bearing an adamantane fragment exhibit in vitro antimicrobial and antifungal activity against museum microbial strains (Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 6538-P, Candida albicans ATCC 10231, Cryptococcus neoformans) and demonstrate significant advantages over the reference drugs used in clinical practice, such as fluconazole and ampicillin. These compounds are therefore recommended for further in-depth studies."

Journal

Development of a high-resolution multiplex qPCR method to profile microbial consortia in spaceflight water recovery systems. (PubMed, Biofilm) - "Here, we report on the development and validation of a multiplex quantitative Polymerase Chain Reaction (qPCR) method to identify and quantify members of a five species model biofilm community acquired from the ISS. Species-specific primers and probes detect organisms to an estimated detection limit of 104-106 CFU and detect the specific targeting of C. metallidurans by ampicillin when overall population levels were not significantly changed."

Journal

Sublethal Antibiotic Exposure Induces Microevolution of Quinolone Resistance in Pathogenic Vibrio parahaemolyticus. (PubMed, Int J Mol Sci) - "A phenotypic analysis revealed that VPD14M exhibited resistance to ampicillin, levofloxacin and ciprofloxacin, compared to VPD14. Whole-Genome Sequencing identified that the acquired resistance was primarily attributable to key point mutations in three Quinolone Resistance-Determining Regions (QRDRs). Specifically, a G → T substitution at nucleotide position 248 in the gyrA gene, leading to a serine-to-isoleucine substitution at the 83rd amino acid position (Ser83Ile) of the DNA gyrase subunit A; a C → T substitution at position 254 in the parC gene, resulting in a serine-to-phenylalanine substitution at position 85 (Ser85Phe) of the topoisomerase IV subunit A; and a C → T substitution at position 2242 in the gyrB gene, causing a proline-to-serine substitution at position 748 (Pro748Ser) of the DNA gyrase subunit B. Collectively, the study demonstrated that sublethal antibiotic levels rapidly drive quinolone resistance in V. parahaemolyticus, and the specific mutations..."

Journal

The Apparent pH Stability of Antibiotic Preparations Used for Uterine Infusions in Mares. (PubMed, Animals (Basel)) - "In experiment 1, amikacin, ampicillin, ceftiofur, ciprofloxacin, gentamicin, penicillin G potassium, penicillin G procaine, and ticarcillin clavulanate were diluted in saline and lactated Ringer' s solution and stored at 5 ° C, 21 ° C, and 37 ° C for 24 h. Solutions were evaluated for pH and physical characteristics at 0, 1, 3, 6, and 24 h after storage. In conclusion, the pH stability of uterine infusions is affected by various storage conditions and vehicles, underscoring the importance of evaluating antibiotic treatments for quality control. While pH changes were observed, the potential impact on the overall stability or antimicrobial activity of the solutions requires further investigation."

Journal • Endometriosis • Infertility

Chemical Profiling, Ampicillin Interaction Patterns, and Exploratory Molecular Docking of Lauraceae Essential Oils. (PubMed, Int J Mol Sci) - "The docking scores revealed binding affinities of the bioactive compounds towards Dpr protein (4.3-5.8 kcal/mol), DNA gyrase (4.7-7.1 kcal/mol), mono- diacylglycerol lipase (4.4-6.2 kcal/mol), CYP51 (5.8-8.0 kcal/mol), phage-encoded quorum sensing anti-activator (5.8-8.0 kcal/mol) and Chondroitin ABC lyase I (4.8-6.3 kcal/mol). Two (2) hit compounds (α-Citral, β-Citral) were finely defined by strong hydrophobic and hydrophilic interactions with the bacterial and fungal protein targets, respectively."

Journal • Infectious Disease • Influenza • Respiratory Diseases

Poultry Proteus mirabilis in selected areas of Hunan, China: Resistance profiles and virulence genes. (PubMed, Poult Sci) - "Resistance was most frequent to Trimethoprim - Sulfamethoxazole (SXT) (81.4%), Ampicillin (AMP) (79.7%), Ciprofloxacin (CIP) (78.0%), and Gentamicin (GEN) (75.4%), followed by Neomycin (NEO) (63.6%) and Chloramphenicol (CHL) (61.0%). Carbapenem resistance was detected in a subset of isolates, including meropenem (MEM) (6.8%) and imipenem (IPM) (11.0%)...In summary, poultry-derived P. mirabilis in Hunan demonstrated high MDR prevalence and frequent carriage of resistance-, virulence-, and environment-related markers. Our findings enrich the epidemiological data on Proteus mirabilis at the farm level and provide scientific guidance for the prevention and control of this disease."

Journal • Infectious Disease

Prevalence and Antimicrobial Resistance Profiles of Bloodstream Pathogens in Feni, Bangladesh. (PubMed, Biomed Res Int) - "Gram-negative isolates exhibited high resistance to ampicillin, amoxyclav, and cefuroxime, whereas amikacin maintained > 70% sensitivity. Gram-positive isolates were largely resistant to third-generation cephalosporins but were very susceptible to gentamicin and ciprofloxacin...Amikacin demonstrated the highest efficacy, supporting its empirical consideration pending susceptibility results. These findings highlight the urgent need for local antibiogram development and strengthened regional resistance surveillance."

Journal • Infectious Disease

Antimicrobial resistance and real-time PCR detection of blaKPC in Klebsiella pneumoniae isolated from wound infections in a tertiary care hospital. (PubMed, Front Antibiot) - "Out of 560 K. pneumoniae isolates, 110 (19.6%) were resistant to meropenem. These resistant isolates also displayed high rates of multidrug resistance, with over 90% resistant to amikacin, ceftazidime, ampicillin, and cefazolin...In conclusion, K. pneumoniae isolates exhibit a concerning rate of carbapenem resistance mediated by the blaKPC gene. Antimicrobial stewardship and molecular surveillance are crucial for the prevention of the spread of carbapenem-resistant K. pneumoniae in clinical settings."

Journal • Infectious Disease • Pneumonia

Fluoroquinolone resistant Escherichia coli in community: molecular analyses of resistance genes, virulence factors, and antimicrobial susceptibility test. (PubMed, Front Microbiol) - "High resistance rates were observed for ampicillin (100%), nalidixic acid (96.6%), ceftriaxone (83.3%), cefepime (81.5%), ciprofloxacin (81.5%), norfloxacin (81.5%), sulfamethoxazole/trimethoprim (75.9%), and nitrofurantoin (71.9%). The frequent coexistence of resistance determinants, virulence factors, and IncF plasmids highlights the adaptive success of these strains and their potential for sustained dissemination. These findings emphasize the need for continuous genomic surveillance, rational antimicrobial use, and region-specific treatment guidelines to mitigate the impact of MDR UPEC in the community."

Journal • Infectious Disease • Nephrology

Antimicrobial Resistance, Virulence and Resistance Genes in Aeromonas From Diseased Fish in China's Major Freshwater Aquaculture Regions. (PubMed, J Fish Dis) - "These isolates exhibited high resistance to ampicillin (98.1%), erythromycin (84.7%) and rifampicin (54.3%), but were susceptible to chloramphenicol, florfenicol and ceftriaxone. Aeromonas isolates in Jiangxi exhibit high genetic diversity, significant virulence potential, andconcerning antibiotic resistance profiles. Of particular concern is A. hydrophila, which poses a high multidrug-resistance risk."

Journal

Antimicrobial resistance of Escherichia coli in Hungarian wild rats and characterization of a CTX-M-1 type ESBL plasmid. (PubMed, Sci Rep) - "The predominant resistance pattern was combined resistance to ampicillin (17.8%) and tetracycline (12%), with plasmid-associated resistance genes blaTEM-1 and tet(A)/tet(B). Phylogenetically, it exhibits a central relationship to human CTX-M E. coli lineages, suggesting a shared genomic background with globally disseminated, human epidemic E. coli lineages. These findings highlight the role of urban brown rats as reservoirs and potential vectors of antimicrobial resistance within the One Health framework and advocate for enhanced surveillance of AMR in urban wildlife to better understand and mitigate the zoonotic transfer of resistance genes."

Journal • Preclinical

Distribution of serotypes, biotype, and antibiotic sensitivity of Haemophilus influenzae in nasopharyngeal carrier children in Lima, Peru. (PubMed, Rev Peru Med Exp Salud Publica) - "Of the isolates, 9/10 were resistant to sulfamethoxazole/trimethoprim, 3/10 to ampicillin and cefuroxime, 2/10 to azithromycin, and no resistance to ceftriaxone was observed. Understanding the carriage status of H. influenzae and local resistance patterns is useful for empirical antibiotic therapy in invasive infections where this bacterium is suspected."

Journal • Infectious Disease • Influenza • Respiratory Diseases

A Ten-Year Study of the Epidemiology and Antimicrobial Resistance of Bacterial Pathogens Associated with Otitis in Crete, Greece. (PubMed, Clin Lab) - "P. aeruginosa, S. aureus, and the Enterobacterales are the predominant bacterial pathogens causing otitis in our area. Regarding Gram-negatives, although resistance rates to commonly-used antibiotics are low, they are increasing over time. Continued surveillance of the prevalence and antimicrobial susceptibility of bacterial pathogens causing otitis is necessary to reassess updated antimicrobial policies and develop appropriate guidelines."

Journal • Infectious Disease • Otorhinolaryngology

Bacteraemia with Meningitis Caused by Listeria Innocua of Unknown Source in an Elderly Patient with Type 2 Diabetes Mellitus: A Case Report and Literature Review. (PubMed, Eur J Case Rep Intern Med) - "Listeria innocua, although considered non-pathogenic in healthy individuals, can cause severe bacteraemia and meningitis in elderly patients with poorly controlled diabetes mellitus.Third-generation cephalosporins are not effective against all Listeria species; empiric treatment in patients >65 years with diabetes mellitus and meningitis must include ampicillin.Recent molecular studies have identified some atypical L. innocua strains carrying virulence genes, challenging the traditional view of the harmlessness of this species."

Journal • Cardiovascular • CNS Disorders • Diabetes • Hypertension • Infectious Disease • Metabolic Disorders • Oncology • Pain • Type 2 Diabetes Mellitus

KLEBSIELLA PNEUMONIAE-INDUCED NEONATAL SEPTIC SHOCK REQUIRING EXTRACORPOREAL MEMBRANE OXYGENATION IN A LATE-TERM INFANT (WRMC 2026) - "Cefepime and Ampicillin were started. This case highlights the importance of recognizing signs of neonatal sepsis for prompt admission. Klebsiella pneumoniae-induced pneumonia can progress rapidly to severe septic shock requiring ECMO. Educating families regarding severity of neonatal sepsis is critical to initiate timely treatment."

Cardiovascular • Hematological Disorders • Hypotension • Infectious Disease • Leukopenia • Metabolic Disorders • Neutropenia • Pneumonia • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Septic Shock

Penicillin Allergy Evaluation in Pediatric Patients: Safety of Testing without MDM and the Role of Testing to Ampicillin and Duplicate PrePen® (AAAAI 2026) - "Among 265 patients with negative skin testing who underwent oral challenge to a penicillin (primarily Conclusions Penicillin skin testing using penicillin G, PrePen®, and ampicillin—without MDM testing—demonstrated a NPV of 98%. Inclusion of ampicillin identified an additional 33 patients (26.4%) with positive results. These findings suggest MDM may not be necessary in pediatric penicillin allergy testing protocols and that ampicillin should be considered an essential component of penicillin testing."

Clinical • Allergy • Immunology • Pediatrics

Biochemical and structural analyses of metallo-β-lactamase VIM-28: impact of substitutions at residues 224 and 228 on substrate profile, stability, and zinc affinity. (PubMed, Microbiol Spectr) - "Compared with VIM-26 (R228S), VIM-28 displayed decreased Km (12.5 for VIM-28 vs 513 μM for VIM-26; 9.66 vs 150 μM) and increased kcat/Km(15.3 vs 1.81 μM-1s-1; 28.6 vs 5.89 μM-1s-1) for ampicillin and cephalothin, respectively...The combined L224H/R228S substitutions in VIM-1 increased the catalytic efficiency of the enzyme for ceftazidime by more than one order of magnitude...Notably, the R228S substitution improved zinc binding and thermal stability, supporting enzyme function under zinc-limited host conditions. These findings reveal mechanisms driving MBL diversity and highlight evolutionary strategies sustaining antibiotic resistance."

Journal

Prevalence of methicillin-resistant Staphylococcus aureus and multidrug resistance among food handlers in a hospital food and nutrition unit in Rio de Janeiro, Brazil. (PubMed, Lett Appl Microbiol) - "High resistance rates were observed for penicillin, erythromycin, and ampicillin. Methicillin-resistant S. aureus (MRSA) represented 29% of hand isolates and 47% of nasal isolates, and 26% were multidrug resistant. These findings indicate that food handlers may act as reservoirs and transmission sources of antimicrobial resistance in hospital food service settings, highlighting the need for continuous monitoring, strict hygiene practices, and antimicrobial stewardship programs."

Journal • Infectious Disease

Antimicrobial resistance of bacteria isolated in a resource-limited region: the experience of the North Kivu Provincial Reference Laboratory in the Democratic Republic of the Congo. (PubMed, Front Med (Lausanne)) - "In E. coli, resistance exceeded 60% to ampicillin, amoxicillin/clavulanate, and ciprofloxacin...pneumoniae showed uniform resistance to ampicillin and high resistance to cefuroxime, cefotaxime, gentamicin, and colistin...Recommended actions include participation in WHONET/GLASS program and antibiotic stewardship. In the interim, empiric strategies should favor nitrofurantoin for uncomplicated cystitis, judicious aminoglycoside use where appropriate, early culture, and prompt de-escalation, reserving carbapenems for severe ESBL-risk presentations."

Journal • Infectious Disease • Pneumonia

Molecular basis of ampicillin resistance: combinatorial mechanisms and future strategies. (PubMed, World J Microbiol Biotechnol) - No abstract available

Journal • Review

Hidden carriers: multidrug-resistant bacteria in hedgehogs from a wildlife rescue centre. (PubMed, Front Vet Sci) - "coli isolates were obtained on MacConkey agar (MCA) and MCA with cefotaxime and confirmed by MALDI-TOF MS...More than half of the isolates (37/69; 54%) were multidrug-resistant, with resistance most frequently observed to ampicillin and nalidixic acid...The presence of sequence types and resistance genes commonly associated with human and veterinary infections further supports the relevance of rehabilitated wildlife to the broader epidemiology of AMR. Enhancing biosafety practices and antimicrobial stewardship in wildlife rescue operations is therefore essential to mitigate zoonotic risks within a One Health framework."

Journal • CNS Disorders • Infectious Disease • Psychiatry

Role of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Predicting In-Hospital Mortality in Patients With Diabetic Foot Ulcers Undergoing Amputation: A Retrospective Study. (PubMed, Cureus) - "Elevated postoperative NLR and PLR are independent predictors of in-hospital mortality in DFU patients undergoing MLLA. These readily available biomarkers can assist in early risk stratification and guide postoperative management. The study also provides region-specific data on microbial prevalence and antibiotic susceptibility, supporting more targeted empiric therapy in this high-risk population."

Journal • Retrospective data • Diabetes • Metabolic Disorders

Differences in β-lactamase activity and carbapenem resistance among the Bacillus cereus group. (PubMed, Antimicrob Agents Chemother) - "Although all B. luti isolates lacked carbapenemase genes, they exhibited higher minimum inhibitory concentration (MIC) ranges for ampicillin and meropenem...All B. luti isolates and some B. mosaicus and B. cereus s.s. isolates displayed constitutive enzyme activity for penicillin G, whereas most B. mosaicus and B. cereus s.s. isolates displayed inducible activity, and five displayed silent activity...This is the first study to demonstrate interspecies variability within the B. cereus group regarding the presence of carbapenemase genes and β-lactam resistance profiles. These findings provide crucial insights into β-lactam resistance mechanisms in this bacterial group and provide a foundation for further research."

Journal • Infectious Disease

Preferential Encapsulation of DNA Impurities Derived from pAAV Plasmid Backbone into Recombinant Adeno-Associated Virus Capsids. (PubMed, Hum Gene Ther) - "These samples contained 0.49-3.80% detectable DNA impurities derived from the three plasmids, as estimated by the ampicillin resistance gene (ampR)...Analysis of the terminal sequences of the long reads containing backbone sequences revealed that 92.7-98.4% of them contained Rep-binding elements. These results indicate that the pAAV backbone in linear DNA form was cleaved from pAAV-ZsGreen1 by Rep78/68 nicking at trs in the nucleus, and that the single-stranded DNA was efficiently translocated into the capsids through the encapsulating machinery, similar to the rAAV genome."

Journal • Gene Therapies