ampicillin / Generic mfg. - LARVOL DELTA

A Case of Decompensated Cirrhosis Secondary to Sickle Cell Hepatopathy (SCH) Managed With Orthotopic Liver Transplantation (OLT) Followed by Haploidentical Hematopoietic Stem Cell Transplantation (HSCT) (ACG 2025) - "Despite treatment of SCD with transfusions and hydroxyurea, his cirrhosis progressed with refractory ascites, spontaneous bacterial peritonitis, and hepatic encephalopathy. With a MELD score of 36, he underwent successful OLT with the institution's immunosuppression protocol of basiliximab induction, steroid taper, mycophenolate modafinil and maintenance tacrolimus...Complications included cutaneous reaction to ampicillin requiring IV methylprednisolone and ruxolitinib due to initial concern for early GVHD which was later felt less likely based on timing and presentation characteristics. Sirolimus, used for immunosuppression/GVHD prophylaxis, was switched to tacrolimus due to possible cutaneous adverse reaction and was continued to prevent OLT rejection...Patients with SCD who have undergone liver transplantation can have significant risk of graft loss, with studies showing up to 22% requiring re-transplantation due to SCD complications. Our approach addresses both..."

Clinical • Bone Marrow Transplantation • CNS Disorders • Fibrosis • Genetic Disorders • Graft versus Host Disease • Hematological Disorders • Hepatic Encephalopathy • Hepatology • Immunology • Liver Cirrhosis • Sickle Cell Disease • Transplantation

Delayed-Onset Drug-Induced Liver Injury and Immune Hemolytic Anemia: An Uncommon but Critical Complication (ACG 2025) - "To our knowledge, this is the first reported case of simultaneous DILI and DIIHA associated with cefoxitin.Case Description/ A 47-year-old woman with a history of HTN, GERD, and remote biopsy-proven DILI from ampicillin 24 years ago presented with fatigue, nausea, vomiting, and jaundice three weeks after undergoing Roux-en-Y gastric bypass surgery, during which she received cefoxitin...The discharge plan included tapering prednisone and completing six months of rituximab therapy as an outpatient. DILI, often hypersensitivity-related, may occur after a single dose the offending drug within 1–3 weeks...DIIHA is diagnosed by low hemoglobin and haptoglobin, elevated LDH, and positive DAT. Steroids treat severe DILI; DIIHA may require steroids and rituximab to prevent DIC.Figure: Table (1): Labs resultsFigure: Figure (1): Liver Biopsy"

Anemia • Autoimmune Hepatitis • Cardiovascular • Cholestasis • Fatigue • Fibrosis • Gastroesophageal Reflux Disease • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Failure • HP

Retrospective analysis of antimicrobial susceptibility testing illustrates the problem of resistant Staphylococcus species in cats in the northeastern United States. (PubMed, Prev Vet Med) - "Susceptibility was lowest overall to penicillin (48 %), followed by ampicillin (49 %) and erythromycin (62 %), while susceptibility was highest to vancomycin and rifampin (≥99 %)...Compared to coagulase-negative staphylococcal species, S. pseudintermedius had higher MICs for β-lactams, fluoroquinolones, doxycycline, and trimethoprim-sulfamethoxazole...This study underscores the significance of AMR and MDR in feline medicine and One Health. The findings emphasize the need for vigilant AMR surveillance in veterinary practices and antimicrobial stewardship in companion animal medicine."

Journal • Retrospective data • Infectious Disease

Antimicrobial susceptibility and genomic characterization of Lactococcus formosensis, Lactococcus garvieae, and Lactococcus petauri in Hong Kong. (PubMed, Microbiol Spectr) - "Among the three species, the antimicrobial resistance profiles were similar, with resistance being extremely high for rifampicin (100%) and clindamycin (71%-92%), very high for cotrimoxazole (53%-58%), moderate to very high for minocycline (12%-56%) and low for levofloxacin (0%-2%). All isolates were susceptible to ampicillin, ceftaroline, daptomycin, erythromycin, linezolid, meropenem, and vancomycin...No cross-sectoral clustering of isolates was observed for the other two species. There are potential risks associated with consuming ready-to-eat foods contaminated with potential pathogens, which can cause health consequences."

Journal • Infectious Disease

Epidemiology and environmental risks of antibiotic resistant Enterobacterales isolates in different aquatic matrices from North-Western Romania. (PubMed, Epidemics) - "Antibiotic susceptibility testing of 678 Enterobacterales isolates revealed an increased degree of intrinsic resistance to erythromycin (77.9 %), high level of resistance to ampicillin (39.7 %), low frequency of carbapenem resistance (2.36 %), and a percentage of 34.4 % MDR strains. Dendrogram analysis based on ERIC-PCR profiles confirmed the presence of strains with identical DNA fingerprints in non-related aquatic ecosystems. The epidemiology of resistant Citrobacter, Enterobacter, Klebsiella and Escherichia isolates confirmed an extensive migration and environmental dispersion of strains with human health significance, particularly important for water resources."

Journal • CNS Disorders • Psychiatry

Detection and antimicrobial susceptibility of E. coli O157:H7 in the milk supply chain, milking environments and humans in Woliata Sodo, Ethiopia. (PubMed, BMC Microbiol) - "This study confirmed the presence of multidrug resistant E. coli O157:H7 in the tested sample. Notably, the highest prevalence was detected in milk samples from collection centers, underscoring post harvest contamination as a critical point of intervention. Identification of the pathogen on milkers' hands, farm floors, and human stool samples highlights potential transmission pathways and suggests a tangible risk of foodborne infections. These findings emphasize the critical need for targeted public health strategies, including comprehensive education on hygienic practices and the implementation of effective contamination control measures, to reduce the risk of infection and protect consumer health."

Journal • Infectious Disease

Six-year antimicrobial resistance patterns of Escherichia coli isolates from different hospitals in Gaza, Palestine. (PubMed, BMC Microbiol) - "The resistance pattern of E. coli varies depending on gender, age, and specimen sources, and this should be taken into account when treating E. coli infections."

Journal • Infectious Disease

Listeria SBP After Flexible Sigmoidoscopy: A Case Report (ACG 2025) - "Our case involves the rare incidence of SBP due to Listeria, successfully treated with ampicillin/gentamicin. Historically, Listeria monocytogenes was frequently misclassified as a contaminating diphtheroid, leading to underdiagnosis. Recent trends indicate a rise in Listeria monocytogenes outbreaks, with transmission routes extending beyond traditional sources and therefore is important to include on the differential for SBP in susceptible patients with recent instrumentation."

Case report • Clinical • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Leukopenia

A Case of K. pneumoniae Primary Liver Abscess (KLA) in a Healthy Immunocompetent Patient (ACG 2025) - "IV Zosyn was initiated, and infectious disease was consulted...The routine culture identified K. pneumoniae, resistant to Ampicillin, for which antibiotics were changed to PO Augmentin and Levaquin...Smaller collection measuring about 3cm in maximal diameter.Figure: CT abdomen/pelvis with contrast showing clusters of small hypodensities in the Right Lobe of the Liver. Larger collection measuring about 5cm in maximal diameter."

Clinical • Cardiovascular • Gastrointestinal Disorder • Hepatology • Hypertension • Infectious Disease • Pneumonia

The antibacterial efficacy and effect of tungsten nanoparticles (WO3) on the expression of tetracycline and erythromycin-resistance genes in Streptococcus agalactiae isolated from pregnant women. (PubMed, GMS Hyg Infect Control) - "The results of antibiotic susceptibility assays revealed high-resistance S. agalactiae strains to tetracycline (87%), erythromycin (71.4%), and clindamycin (63%), while resistance rates chloramphenicol, levofloxacin, penicillin and ampicillin were 33.3%, 14.8%, 11.1%, and 7.4%, respectively. In addition to the mentioned antibiotics, it is worth noting that all strains exhibited sensitivity to other antibiotics such as ceftriaxone, linezolid, and vancomycin...In addition, the application of nanostructures induced a considerable down-regulation of the antibiotic resistance genes (tetM, ermB) relative to the untreated isolate. The findings indicate that tungsten trioxide nanoparticles hold the potential to serve as a promising pathway for the development of new antibacterial substances, with the specific aim of addressing the problem of antibiotic resistance in infections caused by S. agalactiae."

Journal • Infectious Disease

Phenotypical and genotypical resistance testing of Pasteurella multocida isolated from different animal species in Austria. (PubMed, Front Vet Sci) - "The most commonly detected resistance genes were against tetracyclines, aminoglycosides and sulphonamides...While the LHB and LHB + CO2 methods demonstrated effective detection of resistance genes, they were associated with a higher rate of false-positive results for ampicillin resistance...Despite the occurrence of false positive results, it is still the most suitable method to detect resistance genes. Our results suggest good efficacy of antibiotics against P. multocida in Austria, however, the risk posed by strains carrying multiple resistance genes should not be overlooked."

Journal

Occurrence and degradation of emerging antibiotic-resistant bacteria in riverine environment with sono, photo, and sonophotocatalytic oxidation under low-frequency ultrasound and sunlight. (PubMed, Photochem Photobiol Sci) - "Survey study conducted revealed that 12% of the participants reported the use of ampicillin, with 75% of the isolates displaying resistance to this antibiotic...The findings underscore the emergence of antibiotic resistance in aquatic bacteria that are typically exposed to antibiotics. This is the first study to demonstrate the feasibility of using inexpensive and renewable solar energy in combination with ultrasound for the purification of ARB-contaminated wastewater, thereby preventing the transmission of ARB and addressing the One Health challenges associated with them."

Journal

A rapid screening method for detection of ampicillin residues in dairy milk. (PubMed, Res Vet Sci) - "The LFA developed using polyclonal antibodies demonstrated the rapid detection of maximum residue limits (MRL) of ampicillin (5 ppb) in milk samples within 8 to 10 min. The kit developed in this study can be used for screening ampicillin residues in milk samples throughout the supply chain, starting from production to consumers' doorstep."

Journal

Paediatric Enterococcal Bacteremia: An Exploration of the Clinical Impact With Emphasis on Antibiotic Resistance. (PubMed, J Paediatr Child Health) - "Antibiotic resistance in enterococci is common in children with underlying diseases and HAIs. The early empirical glycopeptide therapy consideration for high-risk patients is supported by the prevalence of ampicillin resistance. These findings underline the importance of continuous local surveillance to guide appropriate empiric antibiotic selection and highlight the need for further research into long-term resistance trends and paediatric-specific treatment strategies."

Journal • Infectious Disease • Pediatrics

Antimicrobial Activities of Propolis Nanoparticles in Combination with Ampicillin Sodium Against Methicillin-Resistant Staphylococcus aureus. (PubMed, Microorganisms) - "Meanwhile, PNPs weakened bacterial adhesion and aggregation by suppressing icaADBC gene expression, allowing antibiotics to penetrate the biofilm, and exhibiting significant synergistic anti-biofilm activity. In summary, PNPs are promising candidates for combating MRSA-related diseases."

Journal • Infectious Disease

Effectiveness of Implementing Hospital Wastewater Treatment Systems as a Measure to Mitigate the Microbial and Antimicrobial Burden on the Environment. (PubMed, Antibiotics (Basel)) - "The residual antimicrobials in the effluent were benzylpenicillin, cefpodoxime, ciprofloxacin, levofloxacin, azithromycin, clarithromycin, doxycycline, minocycline, and vancomycin, which were removed by ozone treatment on day 1. In contrast, the removal of ampicillin and cefdinir ranged from 19% to 64% even when combined with UV-LED treatment. Our findings will help to reduce the discharge of ARB and antimicrobials into rivers and maintain the safety of aquatic environments."

Journal • Infectious Disease

Uropathogenic Escherichia coli in a Diabetic Dog with Recurrent UTIs: Genomic Insights and the Impact of Glucose and Antibiotics on Biofilm Formation. (PubMed, Microorganisms) - "Most isolates (9/11) were resistant to ampicillin and fluoroquinolones. Sulfamethoxazole-trimethoprim demonstrated the strongest antibiofilm activity, though this was attenuated in glucose-supplemented environments. This research highlights the clinical relevance of glucosuria in diabetic patients and emphasizes the need for therapeutic strategies targeting biofilm-mediated antibiotic tolerance to improve the management of recurrent UTIs."

Journal • Diabetes • Infectious Disease • Metabolic Disorders • Nephrology

Proteus mirabilis from Captive Giant Pandas and Red Pandas Carries Diverse Antimicrobial Resistance Genes and Virulence Genes Associated with Mobile Genetic Elements. (PubMed, Microorganisms) - "Giant panda isolates showed the highest resistance to ampicillin and cefazolin (58.8%), while red panda isolates were most resistant to trimethoprim/sulfamethoxazole (65%) and imipenem (55%). In addition, we found frequent co-localization of drug resistance genes/VAGs with MGEs, indicating a high possibility of horizontal gene transfer (HGT). This study provides crucial insights into AMR and virulence risks in P. mirabilis from captive pandas, supporting targeted surveillance and control strategies."

Journal • Gene Therapies

Resistance Response and Regulatory Mechanisms of Ciprofloxacin-Induced Resistant Salmonella Typhimurium Based on Comprehensive Transcriptomic and Metabolomic Analysis. (PubMed, Antibiotics (Basel)) - "Ciprofloxacin-induced Salmonella resistance involves both target site mutations and extensive reprogramming of the metabolic network. Exogenous metabolite supplementation presents a promising strategy for reversing resistance and enhancing antibiotic efficacy."

Journal • Infectious Disease

Polymicrobial Arthritis Following a Domestic Cat Bite Involving Rahnella aquatilis in an Immunocompetent Patient. (PubMed, Microorganisms) - "The R. aquatilis isolate was susceptible to beta-lactams (excluding ampicillin), quinolones, and co-trimoxazole. The patient received amoxicillin-clavulanic acid and fully recovered within two weeks...It highlights the importance of considering environmental Enterobacterales in animal bite wounds, and the utility of advanced microbiological tools for detecting uncommon pathogens. Broader awareness may improve diagnosis and guide targeted therapy in polymicrobial infections."

Journal • Immunology • Infectious Disease • Inflammation • Pain • Rheumatology

Prevalence and Characterization of the Antimicrobial Resistance and Virulence Profiles of Staphylococcus aureus in Ready-to-Eat (Meat, Chicken, and Tuna) Pizzas in Mansoura City, Egypt. (PubMed, Antibiotics (Basel)) - "All recovered isolates (n = 560) were classified as multidrug-resistant and were resistant to penicillin, oxacillin, and ampicillin. Moreover, 77% (431/560), 24% (134/560), 8% (45/560), and 8.6% (48/560) of isolates were resistant to cefotaxime, ciprofloxacin, azithromycin, and vancomycin, respectively. The current study emphasizes that ready-to-eat pizza is highly contaminated with multidrug-resistant S. aureus, highlighting the urgent need for rationalizing antibiotic use in both veterinary and human medicine to prevent the transmission of resistant bacteria through the food chain. Additionally, strict adherence to good hygienic practices throughout all stages of the food chain is essential to minimize overall contamination and enhance food safety."

Journal • Cardiovascular • Infectious Disease • Pneumonia • Respiratory Diseases • CAT

Resistance of Gram-Negative Bacteria to Cefepime-Enmetazobactam: A Systematic Review. (PubMed, Pathogens) - "The resistance of the studied extended-spectrum β-lactamase (ESBL)-producing and ampicillin C β-lactamase (AmpC)-producing isolates was low (0-2.8% and 0%, respectively). The high activity of cefepime-enmetazobactam against Enterobacterales and selected lactose non-fermenting Gram-negative pathogens, including ESBL-producing and AmpC-producing isolates, makes it a potential carbapenem-sparing agent. The drug should be used after in vitro antimicrobial susceptibility testing in patients with infections caused by OXA-48, KPC, and MBL-producing isolates."

Journal • Review • Infectious Disease • Pneumonia

Prevalence of Antibiotic Resistance Bacteria in Manure, Soil, and Vegetables in Urban Blantyre, Malawi, from a Farm-to-Fork Perspective. (PubMed, Int J Environ Res Public Health) - "All manure isolates exhibited sulfamethoxazole-trimethoprim resistance, with 50% of pig manure E. coli showing cefotaxime resistance. Soil isolates mirrored these patterns (100% ampicillin resistance in K. pneumoniae and 77% cefotaxime resistance in farm soil E. coli). Vegetables displayed severe multidrug resistance (100% E. coli and 80% K. pneumoniae resistant to ≥3 classes), including critical gentamicin resistance (100% E. coli)...and 6.1% in Brassica rapa, suggesting a potential zoonotic transmission route from livestock farms that requires molecular confirmation. These findings demonstrate manure-amended farms as AMR reservoirs, necessitating extended composting and antibiotic stewardship to mitigate One Health risks."

Journal • Infectious Disease • Pneumonia

Does Bovine Raw Milk Represent a Potential Risk for Vancomycin-Resistant Enterococci (VRE) Transmission to Humans? (PubMed, Antibiotics (Basel)) - "The most common resistance frequencies were to ciprofloxacin and erythromycin (102/163, 62.58% both), followed by quinupristin/dalfopristin (93/163, 57.06%), linezolid (65/163, 39.88%), tetracycline (58/163, 35.58%), daptomycin (46/163, 28.22%), chloramphenicol (33/163, 20.25%), ampicillin, tigecycline, and high-dosage gentamycin (8/163, 4.91% all). Resistance to teicoplanin was not observed...Whole genome sequencing confirmed the presence of the complete vanC gene cluster and several virulence genes in both strains. Our findings suggest that while raw milk is unlikely to be a source of vancomycin resistance genes of highest clinical importance (vanA or vanB), it may contribute to the spread of vanC enterococci, which are increasingly associated with human infections."

Journal • Infectious Disease

Molecular and Drug Resistance Characteristics of Haemophilus influenzae Carried by Pediatric Patients with Adenoid Hypertrophy. (PubMed, Microorganisms) - "BLPAR NTHi strains of CC11 are major epidemic strains in pediatric AH. Imipenem resistance in H. influenzae likely results from porin mutations rather than carbapenemase activity. Enhanced surveillance of H. influenzae's role in AH and its resistance patterns is warranted."

Journal • Infectious Disease • Influenza • Pediatrics • Respiratory Diseases