amikacin sulfate / Generic mfg. - LARVOL DELTA

The role of misoprostol in the prevention of amikacin-induced neuronal damage. (PubMed, Tissue Cell) - "On the other hand, while significant improvements were observed in brain weight and brain weight/body weight ratios in the AK + MP group, there was a significant decrease in CYP2B1 mRNA gene expression levels and histopathological changes. According to our results, MP may serve as a potential therapeutic candidate to reduce the severity of oxidative damage induced by AK in brain tissue."

Journal • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Inflammation

Mediastinal mass in an infant: A rare presentation of extrapulmonary tuberculosis. (PubMed, J Postgrad Med) - "GeneXpert of the abscess aspirate showed Mycobacterium tuberculosis (rifampicin resistant)...Antitubercular regimen was modified accordingly (linezolid, amikacin, cycloserine, clofazimine, and ethionamide)...The patient showed clinical and radiological improvement and was discharged after 6 weeks of inpatient stay. However, the patient was readmitted 16 days later with linezolid-induced lactic acidosis, developed measles, and succumbed to measles complication (pneumonia)."

Journal • Cough • Critical care • Human Immunodeficiency Virus • Immunology • Infectious Disease • Measles • Metabolic Disorders • Pediatrics • Pneumonia • Primary Immunodeficiency • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Management of Multidrug-Resistant Acinetobacter Infection Following Open Reduction and Internal Fixation of a Right Acetabular Fracture: A Case Report. (PubMed, Cureus) - "The patient subsequently developed a deep surgical site infection caused by MDR A. baumannii, resistant to multiple antibiotic classes. This case underscores the importance of culture-guided antibiotic selection, a role for the use of local antibiotic therapy. It also highlights therapeutic challenges in managing MDR infections in orthopedic surgery and the need for collaboration with the microbiology team."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Genetic and Microbial Analysis of Invasiveness for Escherichia coli Strains Associated With Inflammatory Bowel Disease. (PubMed, Cell Mol Gastroenterol Hepatol) - "This study highlights the importance of incorporating antibiotic resistance screening for invasion assays used in AIEC identification. Accurately screened invasion phenotypes identified accessory genome elements among E coli IBD isolates that correlate with their ability to invade epithelial cells. These results help explain why single genetic markers for the AIEC phylotype are challenging to identify."

Journal • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

Rectal Administration of Rifampicin and Isoniazid Suppositories: An Alternative Approach for the Treatment of Tuberculosis in a Patient with Multiple Comorbidities. (PubMed, Life (Basel)) - "Although treatment with rifampicin suppositories has demonstrated efficacy in tuberculosis, it is rarely used in practice. This case highlights the importance of individualizing tuberculosis treatment and demonstrates that rectal administration of isoniazid and rifampicin suppositories, combined with intravenous levofloxacin and amikacin, was successfully used to treat tuberculosis in a patient with severe digestive intolerance, highlighting a potential alternative regimen when standard oral therapy is not feasible."

Journal • Gastric Cancer • Infectious Disease • Oncology • Pulmonary Disease • Respiratory Diseases • Solid Tumor • Tuberculosis

Non-Susceptibility of Early-Onset Sepsis Pathogens to the Combination of Ampicillin and Gentamicin Among Neonates in Thailand. (PubMed, Antibiotics (Basel)) - "Pathogenic isolates were susceptible to ampicillin or gentamicin (59%), ampicillin or cefotaxime (42%), and ampicillin or amikacin (72%). A multivariable analysis revealed that patients in the non-susceptible group (n = 18) were more likely to experience late-onset EOS (48-72 h; p = 0.01) and require endotracheal intubation on day 1 (p = 0.04) compared to patients in the susceptible group (n = 31). In areas with high multidrug resistance, broader-spectrum antibiotic therapy (ampicillin plus amikacin) should be considered for neonates who develop clinical sepsis within 48-72 h of birth and experience respiratory failure at birth."

Journal • Infectious Disease • Respiratory Diseases • Septic Shock

THE CLINICAL CASE OF COMBINED HEMATOPOIETIC STEM CELL TRANSPLANT COMPLICATIONS IN PATIENT WITH MYELODYSPLASTIC SYNDROME. (ESPID 2025) - "The conditioning regimen included treosulfan, endocan, melphalan, and anti-thymocyte globulin (ATG); cyclosporine and ruxolitinib were used to prevent GVHD...Morphological confirmation of GVHD was obtained during colonoscopy with P. aeruginosa from the biopsy culture, which is sensitive to colistin and amikacin...Medrol, mycophenolate mofetil, mesenchymal stem cell transplantation, ruxolitinib, basiliximab, and rituximab, treatment with defibrotide, antibiotics, and antiviral therapy led to the short-term improvement in the child's condition...Antibacterial and immunosuppressive therapy was intensified, and eculizumab was used to treat thrombotic microangiopathy...Learning Points/Discussion Combined complications of HSCT pose insurmountable challenges for physicians. Low sensitivity to antibiotics complicates the course of the disease."

Clinical • Infectious Disease • Septic Shock

IT TAKES A LOT OF GUTS (ESPID 2025) - "After an uneventful recovery, she developed a catheter-related infection with Acinetobacter baumannii, treated with meropenem, amikacin, and catheter removal...She received treatments with methylprednisolone, sirolimus, ruxolitinib, thalidomide, infliximab, and ustekinumab on multiple occasions...During her extended 17-month hospital stay, she experienced 17 episodes of BSIs involving Staphylococcus epidermidis and Staphylococcus haemolyticus, Enterococcus faecium (which developed resistance to vancomycin over time), Stenotrophomonas maltophilia, Pseudomonas aeruginosa, Enterobacter cloacae, and Candida glabrata...Key Learning Points Bacterial gastrointestinal translocation presents significant challenges in the post-HSCT setting, contributing to severe complications. In cases where conventional medical therapies are ineffective, intestinal resection can be a life-saving intervention."

Infectious Disease • PIK3CD

Constrictive Bronchiolitis With Paraneoplastic Autoimmune Multi-organ Syndrome Treated With Lung Transplantation (ATS 2025) - "6 months prior, she was diagnosed with abdominal grade 1 follicular lymphoma, treated with Bendamustine and Rituximab...Secondary to radiographic findings consistent with NTM-PD (bronchial wall thickening and mucoid impaction) and pending lung transplant, she was treated with omadacycline, tedizolid, amikacin and clofazimine until sputum culture negativity (3-months)...Post-operatively she was started on Tacrolimus, Mycophenolate Mofetil and Prednisone...Her lymphoma recurrence risk was very low after 2 years of remission following initial treatment, and as her lymphoma was not associated with immunosuppression, post-transplant immunosuppression likely does not increase risk of recurrence. Additionally, while mycobacterium abscessus poses significant risks, intensive treatment in the peri-transplant period can help allow for safe transplantation."

Follicular Lymphoma • Hematological Malignancies • Immunology • Infectious Disease • Lymphoma • Oncology • Pulmonary Disease • Respiratory Diseases • Transplantation

Mycobacterium Avium Complex Biofilm in a Lung Cavity (ATS 2025) - "This was treated with chemotherapy, erlotinib and radiation therapy for brain metastasis...Sputum collected two months pre-operatively demonstrated many acid-fast bacilli (AFB) on smear, and rough and smooth variants of M. intracellulare subspecies chimaera, susceptible to clarithromycin and amikacin. We treated her with oral azithromycin, ethambutol, clofazimine, and omadacycline; inhaled amikacin and off-label ceftazidime-avibactam IV were added for additional coverage during the perioperative period...To our knowledge, this is the first report of MAC biofilm in a human. MAC biofilm within cavities may be a cause of disease that is refractory to medical therapy."

Cough • Fibrosis • Hematological Disorders • Hepatology • Immunology • Leukopenia • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Respiratory Diseases • Solid Tumor

Pulmonary Cavitary Lesions: Mycobacterium Abscessus or Malignancy? (ATS 2025) - "However, five days after discharge, AFB cultures were found to grow Mycobacterium abscessus and she was started on cefoxitin 2 g TID, amikacin 10 mg/kg daily, and PO linezolid 300 mg daily in addition to omadacycline 300 mg daily after FDA approval was obtained. Additionally, NGS testing later revealed elevated PD-L1 expression (90%), and the patient was started on pembrolizumab...After approximately two months of treatment, all antibiotics were discontinued due to side effects including visual disturbance, rash, and confusion. This case highlights the steps taken to evaluate pulmonary cavitary lesions and illustrates the use of the novel drugs omadacycline and clofazimine used to treat what turned out to be a case of Mycobacterium abscessus."

IO biomarker • Chronic Obstructive Pulmonary Disease • Cough • Hepatitis C • Hepatology • Immunology • Infectious Disease • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Respiratory Diseases • Solid Tumor • PD-L1

Exploring evolutionary perspectives and antibiogram analysis of biofilm-forming Staphylococcus aureus in goat mastitis. (PubMed, Vet Res Commun) - "The S. aureus subjected to the Kirby-Bauer disc diffusion method revealed the highest resistance to cefoxitin and oxytetracycline followed by gentamycin, amikacin, trimethoprim + sulphamethoxazole, and vancomycin. The study concluded that biofilm-producing S. aureus is prevalent in dairy goats of different breeds, including Beetal, Teddi, Barbari, and Makhi-cheeni, across various lactation stages (early, mid, and late), regardless of milk collection times in Pakistan of Pakistan with risk to the udder health and milk quality. Moreover, the biofilm formation may be associated with multidrug resistance of study isolates."

Journal • Infectious Disease

Limited predictive power of known resistance genes for phenotypic drug resistance in clinical Mycobacterium abscessus complex from Beijing in China. (PubMed, Antimicrob Agents Chemother) - "Of the total 81 MABC isolates, six strains exhibited clarithromycin (CLM) resistance by day 3 in culture, but only one (16.7%, 1/6) contained a mutation in the rrl gene. Although there were four (4.9%) amikacin-resistant, nine (11.1%) linezolid-resistant, eight (9.9%) clofazimine-resistant, 23 (28.4%) bedaquiline-resistant, and 27 (33.3%) cefoxitin-resistant strains, no known mutations associated with resistance to these antibiotics were found. These results suggest that the explanatory power of known resistance genes for clinical MABC resistance is limited and that other unidentified genes or novel resistance mechanisms may be involved."

Journal • Pulmonary Disease • Respiratory Diseases

Detection of rare β-lactamase bla SCO-1 from a Klebsiella pneumoniae high-risk clone in Peru. (PubMed, JAC Antimicrob Resist) - "Susceptibility to amoxicillin/clavulanic acid, amoxicillin/sulbactam, piperacillin/tazobactam, aztreonam, ceftriaxone, cefotaxime, ceftazidime, ceftazidime/avibactam, cefepime, imipenem, meropenem, ciprofloxacin, trimethoprim/sulfamethoxazole, gentamicin, amikacin and tigecycline was determined using the Kirby-Bauer disc diffusion method...Illumina WGS showed the presence of bla SCO-1 and bla OXA-1, bla SHV-28, bla TEM-1, bla CTX-M-15, as well as genes associated with resistance to quinolones, fosfomycin, aminoglycosides, sulphonamides, trimethoprim and phenicols...Phylogenetic relationships were established by comparisons with 19 K. pneumoniae genomes carrying bla SCO-1 from other countries in the Americas, revealing at least three different clades. This study highlights the importance of genomic surveillance of uncommon antimicrobial resistance genes such as bla SCO-1, which might contribute to further antimicrobial resistance levels in this country."

Journal • Infectious Disease • Pneumonia

Nano-engineered Antibiotic Formulation That Targets Chronic MRSA Infection. (PubMed, Appl Biochem Biotechnol) - "MRSA isolates exhibited complete resistance to ampicillin, ciprofloxacin, amoxicillin, and amoxicillin-clavulanic acid on Mueller-Hinton agar plates...Encapsulation of ciprofloxacin, amikacin, cloxacillin, and vancomycin within vesicles demonstrated improved antimicrobial efficacy against Escherichia coli, Staphylococcus aureus, Acinetobacter baumannii, Klebsiella pneumoniae, and MRSA...The results of this study suggest that liposomal antibiotics hold significant potential for treating severe infections both systemically and topically. They may enhance therapeutic effectiveness while minimizing adverse effects, offering a promising approach to combating antibiotic-resistant bacterial infections."

Journal • Infectious Disease • Pneumonia

Comparison of a modified broth microdilution Sensititre™ SLOMYCOI assay with the CLSI-recommended agar disk elution method for antimicrobial susceptibility testing of Mycobacterium haemophilum. (PubMed, J Antimicrob Chemother) - "The modified Sensititre™ microdilution method is a reliable alternative to the agar disk elution method for AST of M. haemophilum. It provides precise MIC values and is better suited for routine clinical use due to improved reproducibility and efficiency."

Journal • Infectious Disease • Nontuberculous Mycobacterial Disease

Cutaneous manifestations of atypical mycobacterium chelonae: A case report (SID 2025) - "Initial treatment included prednisone 20 mg BID resulted in significant immunosuppression. Treatment for suspected Staphylococcus aureus sepsis included multiple courses of antibiotics for vancomycin, ceftriaxone, daptomycin, tigecycline, linezolid, imipenem and amikacin...Although the nodules began to respond to appropriate treatment with minocycline, azithromycin and tigecycline the patient's condition was compromised by CHF and he expired. The state of Hawaii as well as the field of dermatology are both experiencing physician shortages, which has led to poor dermatologic access in the region [1]. This demonstrates multiple cutaneous manifestations of systemic AFB infection."

Case report • Clinical • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Dermatology • Heart Failure • Infectious Disease • Septic Shock • Ventricular Tachycardia

BromAc® Removes Biofilm From Endotracheal Tubes and Exhibits Antibacterial Effect in Mucoid and Non-Mucoid Pseudomonas Aeruginosa (ATS 2025) - "In vitro, biofilms from mucoidal (PA-183, PA-297, PA-298) and non-mucoidal (PA-201) strains were grown on ETTs in a 48-well plate for 48 hours and exposed to BromAc® 6.25-50ug/5mg/ml +/- antibiotic (Colistin, Tobramycin, Amikacin, Gentamicin at 0.72-64ug/ml) for 24 hours (triplicate). In-vitro, BromAc® alone and in combination with antibiotic removed biofilms and reduced bacterial load of Pseudomonas Aeroginosa. The ability of BromAc® to remove biofilm, especially when caused by Pseudomonas Aeroginosa, holds potential to reduce the burden of VAP in mechanically ventilated patients."

Late-breaking abstract • Infectious Disease • Pneumonia • Respiratory Diseases

Pleural Mycobacterium Avium Complex (MAC) Empyema: A Rare Presentation of Disseminated Mac Infection in a Patient With Systemic Lupus Erythematosus/Dermatomyositis Overlap (ATS 2025) - "Treatment was adjusted to clarithromycin, ethambutol, and rifabutin...He is currently treated with rifabutin, ethambutol, azithromycin, and amikacin with close monitoring via pulmonology, rheumatology, and infectious disease... This case illustrates an atypical presentation of an uncommon infection, specifically the complexities of managing MAC empyema in immunocompromised patients with autoimmune disorders. While MAC infections are rare, their prevalence in immunocompromised patients is increasing, warranting high index of suspicious and aggressive treatment. Importantly, further research into optimal management is needed."

Clinical • Dermatomyositis • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Myositis • Respiratory Diseases • Systemic Lupus Erythematosus • Tuberculosis

A Squeaky Lung Mass: A Case of a Rare NTM Disease (ATS 2025) - "We present the case of a 67-year-old female with a medical history of Hodgkin's disease treated with mantle radiation, breast cancer treated with bilateral mastectomy on anastrozole, and progressive lung disease with bronchiectasis status post-right middle and lower lobe lobectomies...Albuterol, N-acetylcysteine, as well as multiple courses of suppressive antibiotics with azithromycin and trimethoprim-sulfamethoxazole over several years provided some relief...The patient started on moxifloxacin, rifabutin, and ethambutol...Due to her history of bronchiectasis and lung resection, parenteral amikacin was considered. Once diagnosed, treatment courses are recommended to continue for at least 12 months from culture conversion. If culture conversion is not achieved, surgical intervention may be a consideration if tolerated, with an 87% culture conversion rate."

Clinical • Breast Cancer • Bronchiectasis • Hodgkin Lymphoma • Infectious Disease • Nontuberculous Mycobacterial Disease • Oncology • Pulmonary Disease • Respiratory Diseases • Solid Tumor

A Life-saving Journey: Miliary Tuberculosis as ARDS in a Newly Diagnosed AIDS Patient - Early TB Treatment Enables VV ECMO Weaning (ATS 2025) - "Initially, broad-spectrum antibiotics, including meropenem, were administered...Therefore, second-line anti-TB therapy with amikacin and levofloxacin were initiated, along with steroids upon ICU admission...While the timely initiation of injectable anti-TB medications led to significant clinical improvement, careful monitoring is essential. Consulting with infectious disease and tuberculosis specialists is critical to balance the benefits of early treatment against potential risks associated with compromised organ function."

Clinical • Acute Kidney Injury • Acute Respiratory Distress Syndrome • Anorexia • Cough • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Human Immunodeficiency Virus • Hypotension • Infectious Disease • Liver Failure • Metabolic Disorders • Nephrology • Pulmonary Disease • Renal Disease • Respiratory Diseases • Septic Shock • Tuberculosis • CD4

Real-world Experience of Prolonged Treatment for Patients With Treatment-refractory Nontuberculous Mycobacterial Pulmonary Disease (ATS 2025) - "Clofazimine (32.0% vs. 11.0%, p=0.008) and inhaled amikacin (28.0% vs. 9.6%, p=0.015) were more frequently used in the prolonged group. CONCLUSIONS Prolonged treatment increases the risk of adverse events and may elevate the likelihood of acquiring macrolide resistance. Given the similar overall treatment outcomes and occasional delayed culture conversions, prolonged treatment could be a viable option for managing refractory NTM-PD in patients who can tolerate side effects, though careful monitoring for macrolide resistance is recommended."

Clinical • Nontuberculous mycobacteria • Real-world • Real-world evidence • Hematological Disorders • Immunology • Nontuberculous Mycobacterial Disease • Pulmonary Disease • Respiratory Diseases

Longitudinal Changes in St. George's Respiratory Questionnaire Scores Following Culture Conversion in Patients With Mycobacterium Avium Complex Lung Disease (ATS 2025) - P3 | "This abstract is funded by: Insmed Incorporated Rationale Amikacin liposome inhalation suspension (ALIS) is indicated for treatment of Mycobacterium avium complex (MAC) lung disease as part of a combination antibacterial drug regimen for adult patients who do not achieve negative sputum cultures after at least 6 consecutive months of multidrug antibiotic therapy...The same trend was observed across the 3 health domains measured by the SGRQ, with a 7.8 point reduction in Symptoms, 6.2 point reduction in Activity, and 7.9 point reduction in Impact at EOT+3 months (P<0.05 for all). Conclusions After treatment was completed, patients who achieved sputum culture conversion experienced significant reduction in SGRQ scores from baseline, which may indicate improvement across all included health domains."

Pulmonary Disease • Respiratory Diseases

Eosinophilic Systemic Drug Reaction With Multidrug Resistant Mycobacterium Therapy (ATS 2025) - "Treatment was planned with inhaled liposomal amikacin, clofazimine, and minocycline but was not started at the time due to patient reluctance...Based on sensitivities, treatment was started with doxycycline, cefoxitin, inhaled liposomal amikacin, and clofazimine...The presence of HHV-6 DNA suggests a potential reactivation of latent infection, which may have contributed to the patient's immune response and exacerbated his condition. Clinicians should remain vigilant for signs of DRESS and consider viral infections in patients receiving prolonged antimicrobial therapies."

Cough • Dermatology • Eosinophilia • Epstein-Barr Virus Infections • Infectious Disease • Pain • Pneumonia • Pulmonary Disease • Respiratory Diseases

The Culprit Was Under the Nose: A Refractory Case of Chronic Sinusitis With Polyposis Due to P. Aeruginosa Colonization (ATS 2025) - "This is a 39-year-old male with History of Aspirin-exacerbated respiratory disease (AERD), CRSwNP, and who has been followed by Allergy and ENT due to unrelenting sinusitis for the past ten years...He received Omalizumab and Dupilumab a year and a half each with no improvement seen...ID was consulted and recommended 21 days of IV antibiotics, amikacin nasal rinses, and to start dupixumab...Highly-virulent organisms like Pseudomonas are known to infect CRS patients after surgeries, and require IV antibiotics to adequately treat, but are associated to immunocompromise states and Cystic fibrosis (CF). This case shows how Pseudomonas infection may also occur in an immunocompetent, non-CF patient, thus should remain in the differential in patient with recurrent disease."

Clinical • Chronic Rhinosinusitis With Nasal Polyps • Cough • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Inflammation • Nasal Polyps • Otorhinolaryngology • Pain • Respiratory Diseases • Sinusitis