amikacin sulfate / Generic mfg. - LARVOL DELTA

Lung microbial dysregulation and TNF inhibition are associated with worsened nontuberculous mycobacterial lung disease. (PubMed, Front Microbiol) - "Young (4-7 years old) rhesus macaques were either pretreated with: (1) nebulized amikacin and vancomycin to disrupt the lung microbiome; (2) the TNF inhibitor Inflectra to suppress Th1 responses; or (3) left untreated. No control animals showed granulomas. These data suggest that lung microbiome disruption and TNF inhibition are associated with increased susceptibility to NTM granulomatous disease."

Journal • Immunology • Nontuberculous Mycobacterial Disease • Primary Immunodeficiency • Pulmonary Disease • Respiratory Diseases

Mycosis Fungoides with Vasculopathic, Granulomatous, and Syringotropic Features Presenting with Severe Ischemia and Digital Necrosis (EADV 2026) - "Cultures from wound exudate and skin biopsy tissue grew multidrug-resistant Pseudomonas aeruginosa sensitive only to meropenem and amikacin...Systemic treatment with methotrexate (up to 20mg/week) showed limited response, prompting recent initiation of mogamulizumab...While granulomatous syringotropic MF has been previously described, the addition of vasculopathic involvement with resultant tissue loss is novel. It highlights several critical clinical lessions: (1) vasculopathic involvement in MF can be a cause of severe ischemic tissue loss; (2) vascular interventions may be futile or harmful when the underlying cause is lymphomatous vasculopathy; (3) the 7-year diagnostic delay underscores the challenge of diagnosing MF; and (4) early, accurate diagnosis through multidisciplinary collaboration and comprehensive histopathologic evaluation is essential for optimal management of complex MF variants."

IO biomarker • Cardiovascular • Cutaneous T-cell Lymphoma • Dermatology • Hematological Disorders • Immunology • Mycosis Fungoides • Oncology • Sezary Syndrome • Vasculitis • CD4

Comparison of Lateral Flow Test and PCR for Carbapenemase Detection in Carbapenem-Resistant Klebsiella pneumoniae and the Ceftazidime-Avibactam Resistance Profile. (PubMed, Niger J Clin Pract) - "These findings highlight the importance of rapid and easily applicable diagnostic tests, as well as the urgent need for new antimicrobial agents and novel therapeutic approaches (e.g, Phage therapy, immunotherapies)."

Clinical • Journal • Infectious Disease • Pneumonia

Combined antibacterial activity of imipenem-funobactam with different antibiotics against carbapenem-resistant gram-negative bacteria in China. (PubMed, Int J Antimicrob Agents) - "IPM-FNB combined with sulbactam shows promising activity in vitro against CRAB that may warrant further investigation. In addition, IPM-FNB combined with aztreonam demonstrates promising in vitro synergistic activity against CREC and CRKP, including both KPC-2- and NDM-producing isolates. Additive activity was most common in IPM-FNB combinations against CRPA."

Journal • Infectious Disease • Pneumonia

Successful Treatment of Nocardia Infection Presenting As Tumor-Like Skin Lesions for 17 Years: A Case Report (EADV 2026) - "Initial treatment with itraconazole (0.2g daily for 2 weeks) was ineffective...Single surgical excision is insufficient for the treatment of such long-standing cutaneous nocardiosis, and combined systemic antimicrobial therapy (amikacin, TMP-SMX, clarithromycin) with surgical intervention can significantly improve the therapeutic effect and reduce recurrence...B, Dry wrinkled pink colonies were observed in yeast submerged medium after seven days of culturing. C, The colonies were picked for weak acid-fast staining, and short red bacilli were observed (×1000)."

Case report • Clinical • Infectious Disease • Mood Disorders • Oncology • Respiratory Diseases • Skin Cancer • Tuberculosis

Between grains and pain: Therapeutic challenges in six cases of mycetoma (EADV 2026) - "Results Six cases were included, comprising five actinomycetomas and one eumycetoma.Among actinomycetoma cases, three patients received Cotrimoxazole monotherapy (40 mg/kg/day), with favorable outcomes in two cases with almost complete clinical regression and no relapse after two years of follow up.In the third patient, treatment had to be discontinued due to a maculopapular drug eruption.An alternative therapeutic regimen was therefore initiated, consisting of an intensive phase with intramuscular Amikacin (15 mg/kg/day) administered for three weeks per month combined with Ciprofloxacin (500 mg twice daily) for three months...The remaining two patients, who presented with bone involvement, were treated with triple antibiotic therapy consisting of Cotrimoxazole (10 mg/kg/day), Amoxicillin–clavulanic acid (1 g three times daily) and Amikacin (15 mg/kg/day administered in cyclical regimens), resulting in progressive clinical improvement over a two years follow up period.In..."

Clinical • Infectious Disease • Pain

A successful case report of the treatment of HRAS-mutant inflammatory linear verrucous nevus following Mycobacterium obuense infection with sequential therapy using secukinumab and guselkumab (EADV 2026) - "After six months of combined antimicrobial therapy (amikacin, rifampicin, isoniazid, clarithromycin), the infection was controlled...After failure of acitretin treatment, secukinumab was added...Neither biologic agent induced reactivation of non-tuberculous mycobacteria, indicating their safety in settings of co-infection. This case highlights the clinical value of sequential use of IL-17i and IL-23i in achieving the therapeutic goal of "induced response–long-term maintenance." Future research should focus on elucidating the molecular mechanisms underlying HRAS regulatory region mutations ."

Case report • Clinical • Immunology • Infectious Disease • Inflammation • Nontuberculous Mycobacterial Disease • Pruritus • Psoriasis • Rare Diseases • Respiratory Diseases • HRAS • IL17A • IL23A

TITLE- AN UNSUAL PRESENTATION OF CUTANEOUS MYCOBACTERIA ABSCESSUS AS SPOROTRICHOSIS AND RESPONSE TO LINEZOLID (EADV 2026) - "The treatment consist of Macrolide and a parenteral agent such as amikacin, cefoxitin, imipenem or tigecycline, or combination of parenteral agents. Response to Linezolid is very poor (48% ). Our patient responded well to monotherapy of Linezolid."

Infectious Disease • Inflammation

A Preventable Source of Cutaneous Mycobacterium abscessus Infection: Contaminated Insulin Syringes in a Patient with Diabetes Mellitus (EADV 2026) - "Case Presentation A 48-year-old woman with type 2 diabetes mellitus treated with insulin glargine, metformin, and weekly semaglutide presented with a two-month history of painful inflammatory lesions involving both upper extremities...Multiple empirical antibiotic regimens, including dicloxacillin, clindamycin, and ciprofloxacin, were ineffective...Broth microdilution susceptibility testing according to Clinical and Laboratory Standards Institute guidelines demonstrated susceptibility to amikacin, clarithromycin, azithromycin, tigecycline, omadacycline, and tedizolid; intermediate susceptibility to imipenem and cefoxitin; and resistance to fluoroquinolones and linezolid...Negative stains and molecular assays do not exclude the diagnosis, and prolonged mycobacterial culture remains essential. This case highlights the importance of species identification and antimicrobial susceptibility testing to guide targeted multidrug therapy."

Clinical • Aesthetic Medicine • Diabetes • Infectious Disease • Inflammation • Metabolic Disorders • Mood Disorders • Nontuberculous Mycobacterial Disease • Respiratory Diseases • Type 2 Diabetes Mellitus

Extrapulmonary Nontuberculous Mycobacteria (EP-NTM) Infection in a 66-year-old patient - A Case Report (EADV 2026) - "Combination therapy with azithromycin (250 mg/day), rifampicin (600 mg/day), and ethambutol (15 mg/kg/day) was initiated...However, due to persistently positive sputum cultures throughout the treatment course, an extension of the antimicrobial regimen with amikacin and clofazimine is currently being considered...Primary cutaneous manifestations may occur in the complete absence of pulmonary symptoms and may also present with a disseminated distribution pattern, in contrast to the sporotrichoid distribution typically observed in other nontuberculous mycobacteria infections. This case highlights the crucial role of dermatology in diagnosing extrapulmonary nontuberculous mycobacteria infections."

Case report • Clinical • Nontuberculous mycobacteria • Cytomegalovirus Infection • Epstein-Barr Virus Infections • Hepatology • Infectious Disease • Nontuberculous Mycobacterial Disease • Respiratory Diseases • CD4 • CD8

Antibiotic Susceptibility of Mycobacterium abscessus on the Single-Cell Level (NACFC 2026) - "Mab cells also display growth phase-dependent drug susceptibility and are less susceptible to antibiotics like amikacin when at stationary phase... Biofilm growth results in increased cell-to-cell heterogeneity, which contributes to antibiotic resistance in Mab. Mab is known to form biofilms during infection, so this finding may help explain why in vitro drug susceptibility data often does not reflect in vivo drug efficacy. Cells within Mab biofilms display spatially-dependent physiologies, suggesting that drug susceptibility may also be correlated with where a cell is in a biofilm."

Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Nontuberculous Mycobacterial Disease • Respiratory Diseases

CF-HEAR: Rates of Hearing and Vestibular Abnormalities in People with Cystic Fibrosis Exposed to Ototoxic Therapies (NACFC 2026) - "Participants included PwCF ages 6 years and older currently or recently prescribed an oral macrolide (azithromycin) and/or an inhaled or intravenous (IV) aminoglycoside (amikacin or tobramycin)...In the three years prior to enrollment, 89% of PwCF were prescribed chronic azithromycin, 38% inhaled tobramycin, and 15% IV tobramycin... Utilizing a standardized screening approach for testing hearing and vestibular abnormalities in PwCF exposed to ototoxic medications, we identified a significantly higher proportion of PwCF with abnormalities than is reported in CF Foundation patient registry data. As the lifespan of PwCF continues to increase, this underscores the vital importance of a standardized, easily accessible approach to assessing this in PwCF to identify opportunities for intervention to improve quality of life."

Cystic Fibrosis • Genetic Disorders • Immunology • Otorhinolaryngology • Respiratory Diseases

Two Morphotypes, Two Strategies: Metabolic Drivers of Nitric Oxide Tolerance in Mycobacterium abscessus (NACFC 2026) - " We investigated whether MABR has a survival advantage over MABS under infection-mimicking conditions: zinc limitation, oxygen deprivation, nitric oxide exposure, and treatment with the clinically relevant antibiotics amikacin and azithromycin. NO is produced by host immune cells, serves as a key antimicrobial effector and has also been administered therapeutically in CF care. Here we demonstrate that MABR exhibits substantial tolerance to NO, mediated by the PAA pathway. Given that NO is both naturally generated during infection and used as an inhaled therapeutic in CF, bacterial metabolism may influence the efficacy of NO-based treatment and could create selective pressure favoring the emergence of MABR."

Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Inflammation • Respiratory Diseases

Nitric Oxide Enhances Antimicrobial Effects of Clofazimine Against Mycobacterium abscessus (NACFC 2026) - "We also performed 3-D checkerboard assays in one laboratory strain (ATCC 19977) combining CFZ + dNO with seven antibiotics (amikacin, cefoxitin, linezolid, tedizolid, bedaquiline, omadacycline, and imipenem). Inhaled NO is a promising adjunctive therapy for MAB, particularly when combined with CFZ. However, NO-antibiotic interactions are complex, and further research is needed to guide the selection of optimal antibiotic regimens."

Cardiovascular • Infectious Disease • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Pediatric Subcorneal Pustular Dermatosis Triggered by Mycobacterium abscessus: A Rare Association and Literature Review (EADV 2026) - "Blood cultures identified Mycobacterium abscessus , which was exclusively sensitive to amikacin...The close temporal relationship between systemic mycobacterial flares and cutaneous disease activity, supported by characteristic histopathology and rapid response to targeted antimicrobial therapy, suggests a reactive immune-mediated process rather than primary skin infection. Early recognition of this association and thorough systemic evaluation are essential, as prompt treatment of the underlying trigger can result in favorable outcomes even in complex immunocompromised pediatric settings."

Clinical • Review • Bone Marrow Transplantation • Dermatology • Infectious Disease • Inflammation • Nontuberculous Mycobacterial Disease • Pediatrics • Respiratory Diseases • Transplant Rejection • IFNG

High-Dose Inhaled Colistin-Aminoglycoside Combination Therapy in Critically Ill Patients With Multidrug-Resistant Pseudomonas aeruginosa Hospital/Ventilator-Associated Pneumonia: A Case Report and Literature Review. (PubMed, Case Rep Crit Care) - "All received adjunctive high-dose inhaled colistin immediately followed by inhaled amikacin or tobramycin, in addition to systemic therapy. High intrapulmonary concentrations achieved through aerosolization may overcome resistance while maintaining acceptable systemic safety. Prospective PK-guided studies are warranted."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases

Systemic lupus erythematosus complicated by refractory Mycobacterium avium complex infection involving bilateral lower extremities: a case report and literature review. (PubMed, Front Med (Lausanne)) - "We report a 52-year-old female with SLE on long-term prednisone, azathioprine, leflunomide, and hydroxychloroquine, who developed bilateral tibial and femoral osteomyelitis complicated by soft tissue abscesses, drug-induced dermatitis, and severe malnutrition...She underwent five surgical debridements and prolonged multidrug antimycobacterial therapy (azithromycin, rifampicin, ethambutol, amikacin), along with nutritional support and immunosuppressant adjustment...mNGS enables rapid pathogen identification and is crucial for diagnosing complicated infections. Management requires combined surgical debridement, prolonged antimycobacterial therapy, and multidisciplinary care."

Journal • Dermatitis • Dermatology • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Lupus • Nontuberculous Mycobacterial Disease • Respiratory Diseases • Systemic Lupus Erythematosus

Colistin therapy and survival outcomes in neonatal carbapenem-resistant gram-negative sepsis. (PubMed, Daru) - "A colistin-containing regimen was associated with significantly improved survival among neonates with CR-GN sepsis. Despite limitations in susceptibility testing, these findings underscore the clinical value of colistin in resource-limited NICUs, warranting prospective validation of dosing, safety, and antimicrobial stewardship strategies."

Journal • Retrospective data • Critical care • Infectious Disease • Septic Shock

Pulmonary nocardiosis mimicking malignancy on 18 F-FDG-PET/CT in a patient with a history of melanoma (EANM 2026) - "The patient was placed on intravenous trimethoprim/ sulfamethoxazole and amikacin, with gradual clinical improvement. Pulmonary nocardiosis can exhibit high FDG uptake and mimic metastatic malignancy on PET/CT. This case highlights the importance of considering infection as a differential diagnosis of hypermetabolic pulmonary nodular lesions on 18F-FDG-PET/CT, even in patients with prior malignancy. 18F-FDG-PET/CT is valuable in determining the extent of infection, guiding biopsies, from the most metabolically active lesions for a definite diagnosis, and assessing treatment response."

Clinical • FDG PET • Chronic Obstructive Pulmonary Disease • Cough • Cutaneous Melanoma • Immunology • Infectious Disease • Melanoma • Oncology • Pulmonary Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections • Skin Cancer • Solid Tumor • Tuberculosis

Genomic characterization of CTX-M-15-producing Klebsiella pneumoniae ST709-KL9 from neonatal bacteraemia in eastern India. (PubMed, Mol Biol Rep) - "This single-isolate genomic study is the first report of blaCTX-M-15-caryying MDR K. pneumoniae ST709-KL9 in India. Systematic and strategic large-scale genomic AMR surveillance is essential to understand the trafficking and contain the transmission of emerging pathogens in India."

Journal • Infectious Disease • Pneumonia

Virulence arsenal and antibiotic resistance backgrounds in Pseudomonas aeruginosa isolates from hospital wastewater samples from Iraq. (PubMed, Mol Biol Rep) - "The most P. aeruginosa isolates possessed toxA and lasB genes. The results indicated that hospital effluents are critical sources of MDR and virulent P. aeruginosa, and there is an urgent demand to improve the management of wastewater."

Journal

Phenotypic antimicrobial resistance associated with different bla genotypes and their combinations in Enterobacterales. (PubMed, Ceylon Med J) - "In conclusion, this study showed that Enterobacterales with different bla gene combinations manifest variations in phenotypic resistance to both β-lactam and non-β-lactam antibiotics."

Journal

IMPACT OF BILE CULTURES ON ANTIBIOTIC MANAGEMENT IN ACUTE CHOLANGITIS (UEGW 2026) - "Anaerobic bacteria were identified in 3.9% of positive cultures, and Candida species accounted for 10.2% of isolates.Overall susceptibility analysis showed that amikacin was the most active antibiotic (93.3%), followed by imipenem (77.9%) and piperacillin–tazobactam (77.2%). Ceftriaxone demonstrated intermediate activity (66.7%), whereas amoxicillin–clavulanate showed low overall sensitivity (31.4%), particularly in grade II disease.Antibiotic therapy was modified in 46 patients (38.0%)... Bile cultures in acute cholangitis show a high microbiological yield, dominated by Gram-negative organisms with heterogeneous resistance profiles. More than one-third of patients required antibiotic modification, most often enabling de-escalation after effective drainage. These findings support the clinical value of bile sampling to optimise antibiotic management in routine practice."

Cholangiocarcinoma • Gallbladder Cancer • Hepatology • Infectious Disease • Pneumonia • Solid Tumor

THE RELEVANCE OF LIVER BIOPSY IN PATIENTS WITH HUMAN IMMUNODEFICIENCY VIRUS AND CHOLESTASIS: A CASE OF HEPATIC TUBERCULOSIS MIMICKING DRUG-INDUCED LIVER INJURY (UEGW 2026) - "Suspected drug-induced liver injury (DILI) prompted a switch to amikacin, levofloxacin, ethambutol, and meropenem...The patient was discharged on levofloxacin, rifampicin, isoniazid, and ethambutol, in addition to prednisone, ART, and standard treatment for neurotoxoplasmosis.Two months later, he was readmitted with vomiting and jaundice...Microscopy for acid-fast bacilli was negative, but the Xpert MTB/RIF confirmed hepatic tuberculosis and rifampicin resistance.A multidrug-resistant tuberculosis regimen was initiated (levofloxacin, clofazimine, bedaquiline, and terizidone) leading to an 80% reduction in alkaline phosphatase and normalization of serum bilirubin within three months.This case highlights the challenge of distinguishing DILI from opportunistic infections in advanced HIV, particularly in cholestatic presentations with hepatotoxic drug exposure. Noninvasive tests may be insufficient, emphasizing the role of liver biopsy and molecular testing in management."

Biopsy • Clinical • Cholestasis • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Liver Failure • Respiratory Diseases • Septic Shock • Tuberculosis

Phenotypic Susceptibility, Resistance-Associated Genomic Determinants, and Mobile-Genetic-Element Context of Canine Otitis Externa-Associated Pseudomonas aeruginosa Collected in Hungary in 2010 and 2017. (PubMed, Vet Sci) - "European Committee on Antimicrobial Susceptibility Testing epidemiological cut-off values identified non-wild-type subsets for ciprofloxacin (7/67), tobramycin (4/67), imipenem (1/67), and piperacillin-tazobactam (51/67), whereas all isolates remained within the available wild-type distributions for ceftazidime, gentamicin, and amikacin. The discordance between conserved resistance-gene repertoires and heterogeneous MICs demonstrates that sequence-based detection alone is insufficient for therapeutic inference. Integrated phenotypic and genomic surveillance is therefore required to support evidence-based antimicrobial stewardship in canine pseudomonal otitis."

Journal • Otorhinolaryngology