amikacin sulfate / Generic mfg. - LARVOL DELTA

A Comparative Analysis of Resistance Patterns in Rifampin-Resistant Tuberculosis: Mutations Within and Outside the Rifampicin Resistance-Determining Region. (PubMed, Cureus) - "Background Rifampicin resistance in tuberculosis (TB), often linked with isoniazid resistance, defines multidrug-resistant TB. Conclusions Mutations in the RRDR remained the primary drivers of MDR-TB. However, mutations outside the RRDR suggested a potential association with amikacin resistance, necessitating expanded molecular surveillance and larger studies for validation."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Establishment of an In Vitro Neurovascular Unit Model With Blood and Brain Components and Investigation of Its Blood-Brain Barrier. (PubMed, J Biomed Mater Res A) - "Permeability to tracers was significantly reduced in the multicellular model, and ceftriaxone showed higher transport than amikacin, reflecting human BBB selectivity. This model provides a physiologically relevant platform for neurovascular research and drug screening."

Journal • Preclinical • CD31 • PECAM1

Omadacycline as a drug candidate for Mycobacterium avium infections: in vitro insights on single and combination therapies. (PubMed, J Antimicrob Chemother) - "Omadacycline demonstrated in vitro activity against M. avium, particularly in combination with amikacin. Emergence of clarithromycin and amikacin resistance seemed to be prevented by co-exposure to omadacycline. Further research is warranted to assess omadacycline's role in treating M. avium disease."

Journal • Preclinical • Infectious Disease

Efficacy of ceftazidime-avibactam for the treatment of central nervous system infection caused by carbapenem-resistant Klebsiella pneumoniae after neurosurgery. (PubMed, Front Neurol) - "No relapses were reported in treated patients during a follow-up period of 3-12 months. Intravenous CAZ-AVI combined with intracerebroventricular or intrathecal polymyxin B or amikacin demonstrated promising efficacy as a treatment regimen for CRKP-induced CNS infections."

Journal • CNS Disorders • Hepatology • Infectious Disease • Liver Failure • Pneumonia • Ventriculomegaly

Clonal dissemination of carbapenem-resistant ST477 Klebsiella michiganensis co-producing NDM-1, SFO-1, and VEB-3 in a Chinese hospital. (PubMed, Front Cell Infect Microbiol) - "Antimicrobial susceptibility testing showed high-level resistance to imipenem, meropenem, and ceftazidime-avibactam, while susceptibility was retained to amikacin, aztreonam-avibactam, eravacycline, tigecycline, and colistin. No ST477-related genomes were identified in current public datasets. This study is the first to report the clonal dissemination of ST477 K. michiganensis harboring bla NDM-1 in a Chinese hospital."

Journal • Critical care

Chronic Respiratory Infections And Bronchiectasis: A Case of Specific Antibody Deficiency And Strommen Syndrome (ACAAI 2025) - "Antimicrobial regimens (clofazimine, amikacin, azithromycin, ethambutol, bedaquiline) led to minimal clinical improvement over three years. This expands the immunologic spectrum of STIM1-GOF syndromes, reinforcing the need for multidisciplinary care across pulmonology, infectious disease, genetics, and immunology. Recognition of SAD and early IVIG therapy can improve outcomes, mitigate irreversible lung damage, and potentially lead to less antimicrobial resistance."

Clinical • Bronchiectasis • Hematological Disorders • Immunology • Infectious Disease • Myositis • Pneumonia • Primary Immunodeficiency • Pulmonary Disease • Respiratory Diseases • Thrombocytopenia • STIM1

Anti-IFN-gamma Autoantibodies In An Adult Patient With Disseminated Mycobacterium Abscessus Infection (ACAAI 2025) - "Supraclavicular lymph node biopsy showed inflammation with sclerosis, and cultures grew M. abscessus , prompting initiation of amikacin, meropenem, and omadacycline. Seven months later, patient had radiographic and clinical improvement and was transitioned to oral omadacycline and tedizolid for minimum twelve-month course...Identification of anti-IFN-γ autoantibodies is critical given the role of immunomodulatory therapies including rituximab and IFN-γ in patients with antimicrobial-refractory infections. Most recently, CAAR T cell therapy has shown promise in averting anti-IFN-γ autoantibody-related infections by targeting self-reactive B cells."

Clinical • Asthma • Cough • Gastrointestinal Disorder • Herpes Zoster • Immunology • Infectious Disease • Inflammation • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases • Tetanus • Tuberculosis • CD4 • CSF2 • IFNG

Nocardia Brain Abscess in a Previously Healthy Woman: A Diagnostic Clue to Underlying Immune Dysfunction (ACAAI 2025) - "She was started on amikacin, imipenem-cilastatin, and linezolid...After successful antibiotic treatment she was placed on trimethoprim/sulfamethoxazole prophylaxis...This impairs innate immune aspects such as phagocytic activity and T cell response, weakening host defense and enabling development of opportunistic infections beyond the lungs such as CNS nocardiosis and cryptococcosis [6,7,8,9]. This case highlights the importance of considering anti-GM-CSF autoantibodies in patients presenting with disseminated nocardiosis."

Clinical • CNS Disorders • Glaucoma • Human Immunodeficiency Virus • Infectious Disease • Ophthalmology • Respiratory Diseases • CSF2 • SPI1 • STAT5

Going For a Bumpy Ride: Diagnostic Journey in a Child with Granulomas (ACAAI 2025) - "The patient underwent surgical excision of the lesions and was treated with IV amikacin and imipenem for 9.5 months resulting in resolution of her infection...Her clinical picture strongly suggests MSMD as the most probable diagnosis. Although presently considered a heterozygous VUS, her mutation in IFNGR2 is notable and suggests a link to MSMD."

Clinical • Human Immunodeficiency Virus • Immunology • Infectious Disease • Primary Immunodeficiency • Sarcoidosis • IFNAR2 • IFNG

Pediatric Urinary Tract Infections: Pathogen Prevalence, Antibiotic Susceptibility, and Cost-Effectiveness Analysis in a Tertiary Medical Center in Israel. (PubMed, Isr Med Assoc J) - "E. coli was the predominant pathogen in pediatric UTIs among hospitalized children. Carbapenems and amikacin showed high susceptibility but were costly. Fosfomycin demonstrated high susceptibility, favorable cost-effectiveness, and the advantage of oral administration, making it a promising option for empiric treatment. Empiric antibiotic selection should integrate susceptibility patterns, clinical context, and economic considerations."

HEOR • Journal • Retrospective data • Infectious Disease • Nephrology • Pediatrics

Antimicrobial resistance in raw cow's milk in Bwegera, Democratic Republic of the Congo: implications for food safety. (PubMed, BMC Microbiol) - "Inadequate sanitary and pharmaceutical practices foster resistant bacterial strains. Improved farmer education, stricter antibiotic regulations, and alternative interventions such as probiotics are needed within a 'One Health' framework."

Journal • Infectious Disease • Pneumonia

Preclinical evaluation of epetraborole in the hollow fibre system model of Mycobacterium abscessus lung disease. (PubMed, J Antimicrob Chemother) - "Epetraborole microbial kill is the best, thus far, achieved in the HFS-MAB, more than two times omadacycline's 123 cfu/mL below B0. We propose to test a novel combination regimen of epetraborole plus omadacycline plus a β-lactam versus GBT first in the HFS-MAB, followed by clinical trials."

Journal • Preclinical • Pulmonary Disease • Respiratory Diseases

A Case Report on Fortified Drop Toxicity in Refractory Stromal Abscess. (PubMed, Ann Afr Med) - "Further course of treatment included intrastromal injection of vancomycin (1 mg/0.1 ml) and amikacin (0.4 mg/0.1 ml) along with topical antibiotics. Upon no significant improvement in the condition, the patient received therapeutic penetrating keratoplasty as part of a comprehensive approach to control the infection and restore corneal integrity. This case highlights the challenge of managing a recalcitrant corneal stromal abscess with epithelial toxicity from prolonged fortified antibiotic drops, requiring targeted intrastromal therapy and corneal healing."

Journal • Diabetes • Infectious Disease • Keratitis • Metabolic Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation

COVID-19 pandemic increased ESKAPEEc bloodstream infections and amplified carbapenem resistance in Chinese children: a multicenter surveillance study (2016-2023). (PubMed, Front Cell Infect Microbiol) - "Between 2016-2019 and 2020-2023, resistance to ceftazidime and gentamicin decreased in Escherichia coli and Klebsiella pneumoniae while resistance to imipenem and meropenem increased. Acinetobacter baumannii exhibited reduced resistance to most antibiotics except cefotaxime, levofloxacin and amikacin...The MIC values for vancomycin in MRSA strains remained stable over time, whereas a decreasing susceptibility trend to vancomycin in MSSA strains and linezolid MIC shifts were not observed. Our findings are expected to provide to treatment of bloodstream infections in children and evidence on best practices and resource sharing for policy consideration to healthcare providers at the local and international levels."

Journal • Retrospective data • Infectious Disease • Novel Coronavirus Disease • Pediatrics • Pneumonia • Respiratory Diseases

Antimicrobial resistance of Enterobacterales in Central Africa: a systematic review and meta-analysis. (PubMed, Commun Med (Lond)) - "The high prevalence of AMR in Central Africa underscores the urgent need to strengthen antimicrobial susceptibility testing capacities, restrict empirical use of key antibiotics, and ensure equitable access to effective antimicrobials. Without coordinated investments for microbiology capacities scale-up, prescription regulation, strategies for water, sanitation and hygiene, and infection prevention and control, patient outcomes and regional AMR containment will be jeopardized."

Journal • Retrospective data • Infectious Disease

Management and Resolution of Hypersensitivity Pneumonitis-Related Events in Japanese Patients Treated with Amikacin Liposome Inhalation Suspension in the CONVERT and INS-312 Clinical Trials. (PubMed, Infect Dis Ther) - P3 | "At the time of diagnosis, one patient had ground-glass opacity, and the other patient had consolidation in the right lower lobe of the lung; both patients had serum KL-6 levels > 600 U/mL. Changes in chest radiography and KL-6 levels at the onset of respiratory symptoms during ALIS treatment suggest that these assessments may help guide management strategies for potential hypersensitivity pneumonitis in patients taking ALIS.Clinical Trial Registration: NCT02344004 (CONVERT) and NCT02628600 (INS-312)."

Journal • Immunology • Inflammation • Interstitial Lung Disease • Nontuberculous Mycobacterial Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Epidemiology and Drug Resistance of Pulmonary Nocardiosis Among Tuberculosis-Suspected Patients in Guangzhou, China. (PubMed, Infect Drug Resist) - "Antimicrobial susceptibility testing demonstrated that co-trimoxazole, amikacin, moxifloxacin, and linezolid were reliable therapeutic options. In contrast, the tested β-lactams, macrolides, and tetracyclines exhibited high resistance rates, limiting their clinical utility...Morphological analysis serves as an effective tool for reducing the risk of misdiagnosing Nocardia as mycobacteria. Future efforts should focus on optimizing detection methods and conducting multicenter studies to better understand prevalence trends and resistance mechanisms, ultimately improving clinical management."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

A Highly Drug-Resistant Salmonella Enterica Serovar Weltevreden of Human Origin from India and Detection of its Virulence Factors. (PubMed, Indian J Microbiol) - "ampicillin, amikacin, ciprofloxacin, cotrimoxazole, cefepime, ceftriaxone, ceftazidime, cefotaxime, cefuroxime, gentamicin, kanamycin, meropenem, nalidixic acid, nitrofurantoin, norfloxacin, trimethoprim. Although, this study reports a single case of extensively drug-resistant NTS serovar, the possibility of more such serovars circulating in the community cannot be ruled out. Hence, there is an urgent need to implement effective antibiogram surveillance among NTS to detect such serovars and to formulate effective policies regarding antibiotic usage."

Journal • Review • Infectious Disease

Efficacy and Mechanism of Ceftobiprole in Treating Mycobacterium abscessusLung Disease (ChiCTR) - P=N/A | N=100 | Recruiting | Sponsor: Shenzhen Third People's Hospital; Shenzhen Third People's Hospital

New trial

Recurrent Small Bowel Obstruction Secondary to Intestinal Tuberculosis: A Case Report and Review of the Literature (ACG 2025) - "A nasogastric tube was placed and the patient was started on IV rifampin, levofloxacin, amikacin, and linezolid...Intestinal TB may be difficult to diagnose as it can present similarly to pathologies such as intra-abdominal infection, IBD, or malignancy. Misdiagnosis rates of intestinal tuberculosis have been reported to be as high as 50-70%, even in countries with a high prevalence of tuberculosis."

Case report • Clinical • Review • Gastrointestinal Disorder • Hepatology • Infectious Disease • Respiratory Diseases • Tuberculosis

Under Pressure: Granulomatous Liver Disease and Portal Hypertension in Disseminated MAC (ACG 2025) - "The patient was discharged on ethambutol, rifabutin, azithromycin, and IV amikacin. Fig 3. High-power (400X mag) Ziehl-Neelsen stain highlights abundant acid-fast bacilli."

Candidiasis • Cardiovascular • Fibrosis • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • Portal Hypertension

Leclercia adecarboxylata Bacteremia in a Patient With Ulcerative Colitis (ACG 2025) - "The organism was sensitive to ceftriaxone and amikacin. The present case supports the hypothesis that the patient's active UC was the likely source of bacteremia. Literature suggests that UC and other inflammatory GI conditions increase the risk of invasive infections due to gut bacterial translocation."

Clinical • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis • CRP

Management of Refractory Pulmonary Mycobacterium abscessus Infection in a Patient with Bronchiectasis: A Case Experience (WBC 2025) - "Treatment with IV amikacin, IV cefoxitin, oral clarithromycin, and oral clofazimine was initiated on 21 June 2023, but was frequently interrupted by adverse events, including transaminitis, urticarial rash (requiring allergist review and cefoxitin challenge), and PICC complications...Alternative agents (IV meropenem, oral trimethoprim-sulfamethoxazole) were also poorly tolerated...In February 2024, following NTM specialist input, the regimen was revised to IV amikacin, IV tigecycline, oral linezolid, and oral clofazimine...Despite adherence to guideline-based regimens, sustained culture clearance—the traditional marker of treatment success—may remain unattainable in complex cases, necessitating a pragmatic shift in goals of care from microbiological cure to symptom control, functional stability, and prevention of further decline. There is an urgent need for studies to guide optimal treatment regimens beyond first-line agents for refractory or partially responsive..."

Clinical • Bronchiectasis • Chronic Cough • Cough • Dermatology • Fatigue • Immunology • Infectious Disease • Nontuberculous Mycobacterial Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis • Urticaria

A COMPLEX ONGOING CASE OF MEDICAL MANAGEMENT OF EXTENSIVE, RECALCITRANT CAVITARY MYCOBACTERIUM ABSCESSUS LUNG DISEASE (CHEST 2025) - "This isolate was sensitive to amikacin, clofazimine, imipenem, and tigecycline and resistant to cephalosporins...He was started on intensive therapy with IV tigecycline/imipenem and clofazimine in 2020 for four months with clinical and radiologic improvement, then switched to oral continuation therapy with clofazimine and omadacycline to allow him to travel for performances... M. abscessus requires years long intensive, parenteral multidrug regimens, but in some cases, continuous treatment with alternating intensive and continuation phases may be used to accomplish clinical and radiologic improvement for years while allowing for improved quality of life and functionality and limiting drug toxicity. Further research is needed validate new drug combinations for the management of M. abscessus related lung disease."

Clinical • CNS Disorders • Cough • Nontuberculous Mycobacterial Disease • Psychiatry • Pulmonary Disease • Respiratory Diseases • Schizophrenia

Antimicrobial susceptibility patterns and genotypic characteristics of Mycobacterium marinum and Mycobacterium abscessus isolated from cutaneous infections: A retrospective study. (PubMed, J Glob Antimicrob Resist) - "Our findings elucidate distinct antimicrobial susceptibility profiles of M. marinum and M. abscessus isolated from cutaneous infection in China, providing critical guidance for clinical treatment. Cutaneous M. abscessus isolates exhibit extensive drug resistance patterns. Subtyping and erm (41) polymorphism detection serve as reliable predictors of clari-thromycin resistance in M. abscessus."

Journal • Retrospective data • Dermatology • Infectious Disease