aspirin / Generic mfg. - LARVOL DELTA

Predictive Role of Circulating Tumor DNA in Stage III Colon Cancer Treated With Celecoxib: A Post Hoc Analysis of the CALGB (Alliance)/SWOG 80702 Phase 3 Randomized Clinical Trial. (PubMed, JAMA Oncol) - P3 | "Observational studies have associated use of aspirin and selective cyclooxygenase inhibitors with decreased recurrence and improved survival in patients with colon cancer...This was a post hoc analysis of the phase 3 Cancer and Leukemia Group B (now Alliance)/Southwest Oncology Group 80702 randomized clinical trial (2010-2015) assessing adjuvant celecoxib vs placebo and 3 vs 6 months of adjuvant 5-fluorouracil, leucovorin, and oxaliplatin for stage III colon cancer...The findings of this post hoc analysis suggest that ctDNA status has the potential to inform clinical decision-making among patients with stage III colon cancer who should consider adjuvant celecoxib in addition to conventional chemotherapy. ClinicalTrials.gov Identifier: NCT01150045."

Circulating tumor DNA • Clinical • Journal • P3 data • Retrospective data • Colon Cancer • Colorectal Cancer • Hematological Malignancies • Leukemia • Microsatellite Instability • Oncology • Solid Tumor • MSI • PIK3CA

Ponatinib as a consolidation strategy for a second attempt at TKI discontinuation in chronic myeloid leukemia: Interim results from the restop Trial (ASH 2025) - P2 | "The potencyof the third-generation TKI ponatinib makes it a promising candidate to deepen molecular response priorto a second discontinuation attempt.METHODSResToP is a phase II, multicenter, open-label, non-comparative clinical trial that enrolled adult patientswith chronic-phase CML who had previously failed a first TKI discontinuation attempt and hadsubsequently regained a sustained deep molecular response (MR4) for ≥1 year after restarting therapy.Patients received consolidation therapy with ponatinib 15 mg/day and acetylsalicylic acid 100 mg/day for2 years, followed by complete treatment withdrawal. The most frequent grade 1–2 toxicities werehypertension (14.7%), hepatotoxicity, arthralgia, and myalgia (each at 11.8%). One death unrelated totherapy was recorded.CONCLUSIONConsolidation therapy with ponatinib represents an effective and safe strategy for a second TKIdiscontinuation in CML patients after a prior failed withdrawal attempt."

Chronic Myeloid Leukemia • Hematological Malignancies • Hypertension • Leukemia • Musculoskeletal Pain • Myocardial Infarction • ABL1

Aspirin as secondary prevention for colorectal cancer liver metastases (ASAC): A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial. (ASCO 2025) - P2/3 | "This phase 3 trial showed that in patients with colorectal cancer liver metastasis, daily aspirin 160 mg after complete tumor removal did not improve disease-free or overall survival. Additionally, aspirin was associated with an increased incidence of serious adverse events."

Clinical • Late-breaking abstract • P3 data • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor

Dual-drug nanoplatform HPA@NPs reprograms the fibrotic microenvironment by suppressing EMT and M2 macrophage polarization in pulmonary fibrosis. (PubMed, Int Immunopharmacol) - "To overcome these challenges, we developed a multifunctional nanotherapeutic platform, termed HPA@NPs, through co-assembly of hyaluronic acid-platycodin D (HA-PD) and aspirin-platycodin D (ASA-PD) conjugates...In bleomycin-induced PF mice, HPA@NPs significantly improved pulmonary function and attenuated histopathological damage...Importantly, HPA@NPs exhibited no detectable cytotoxicity, hemolytic activity, or major organ toxicity at therapeutic doses, demonstrating favorable biocompatibility. In summary, HPA@NPs integrate precise targeting, multi-pathway synergy, and excellent biosafety, offering a promising translational strategy for PF treatment."

Journal • Fibrosis • Immunology • Inflammation • Interstitial Lung Disease • Pulmonary Disease • Respiratory Diseases • CDH2 • COL1A1 • IL10 • TGFB1 • TJP1 • VIM

Xuming tongmai decoction modulates astrocyte polarization and mitophagy via the PINK1/Parkin pathway in a rat model of acute ischemic stroke. (PubMed, Brain Res) - "XMTM decoction exerts its neuroprotective effects in AIS rats by targeting the PINK1/Parkin-mediated mitophagy pathway, which subsequently promotes the polarization of astrocytes toward the neuroprotective A2 phenotype."

Journal • Preclinical • Cardiovascular • Ischemic stroke • ARG1 • PINK1 • S100A10

Effect of a regional guideline-education initiative on dual antiplatelet therapy use in minor non-cardioembolic stroke: a pre-post analysis from the Shanghai Stroke Service System. (PubMed, Stroke Vasc Neurol) - P=N/A | "Following implementation of a regional guideline-education initiative within 4S, standard DAPT use increased and overall in-hospital stroke recurrence declined. However, the parallel rise in non-standard DAPT use observed in secondary hospitals highlights persistent practice variability and the need for targeted quality-improvement strategies."

Journal • Cardiovascular • Ischemic stroke

Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer. (PubMed, N Engl J Med) - No abstract available

Journal • Colorectal Cancer • Oncology • Solid Tumor

Open repair of a mycotic thoracic aortic aneurysm in a 5-month-old infant. (PubMed, J Vasc Surg Cases Innov Tech) - "TAA open repair and patch aortoplasty with a pulmonary artery allograft was performed. The patient was discharged on antibiotic prophylaxis, aspirin, and diuretic treatment and achieved complete recovery by the 30-day follow-up."

Journal • Cardiovascular • Infectious Disease • Pediatrics

Bridging the Gaps between Aspirin Guidelines and Pregnancy Outcomes. (PubMed, Dela J Public Health) - "With this effort, the rate of appropriate LDA prescription increased from 10% to 65%. Further studies and thoughtful conversations around additional barriers to care must be addressed jointly by researchers, providers, public health officials, patients and the community at large if the full promise shown in randomized controlled trials is to be realized."

Journal • Gynecology

HeartWare™ HVAD support without anticoagulation. (PubMed, Indian J Thorac Cardiovasc Surg) - "This case underscores the importance of a multidisciplinary team approach, along with enhanced patient and family education, to minimize complications and optimize outcomes. We also highlight the evolving antithrombotic strategies in VAD patients, with Antiplatelet Removal and Hemocompatibility Events with a HeartMate 3 (ARIES-HM3) trial supporting aspirin avoidance; however, applying these results to other VADs warrants considerable caution."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Hematological Disorders • Oncology • Osteosarcoma • Pediatrics • Sarcoma • Solid Tumor • Thrombocytopenia • Transplantation

Why low-dose aspirin persists in recurrent pregnancy loss without APS: cognitive bias and system design. (PubMed, AJOG Glob Rep) - "Understanding the cognitive architecture of empirical LDA use enables reproductive medicine to redesign its environment so that good science and good care no longer compete. Recognizing these dynamics can help clinicians and institutions redesign care environments that support evidence-based restraint without diminishing empathy."

Journal • Genetic Disorders • Gynecology • Hematological Disorders • Infectious Disease • Obstetrics

Noninferiority of Aspirin to Other Anticoagulants for VTE Prophylaxis in Low Risk Patients Undergoing Aseptic Revision TKA (AAOS 2026) - "Aspirin is a safe, effective, and noninferior option for VTE prophylaxis following aseptic rTKA in appropriately selected patients."

Clinical • Head-to-Head

Aspirin Versus Potent VTE Chemoprophylaxis in Total Knee Arthroplasty: Reduced Postoperative Pain and Complications with Aspirin Use (AAOS 2026) - "TKA patients treated with potent VTEC versus aspirin experience more postoperative pain in the first 90-days and have an increased odds of stiffness requiring MUA."

Orthopedics • Pain

A Break-Even Cost-Effectiveness Analysis for Venous Thromboembolism Prophylaxis in Achilles Tendon Repair Surgery (AAOS 2026) - "We found that aspirin 81 mg, aspirin 325 mg, and warfarin are cost effective for VTE chemoprophylaxis following surgery for Achilles tendon rupture. Enoxaparin and rivaroxaban are not cost effective."

Cost effectiveness • HEOR • Surgery • Cardiovascular • Venous Thromboembolism

Are Xa Inhibitors Associated with an Increased Risk of Manipulation after Primary Total Knee Arthroplasty Compared to Aspirin in a Contemporary Cohort? (AAOS 2026) - "In a database study of 461,510 primary TKA patients, Xa inhibitor use was associated with an increased risk of manipulation compared to aspirin though rivaroxaban and apixaban were similar."

Orthopedics • Pain

Aspirin May Be a Suitable Prophylaxis for Visceral Organ Malignancy Patients Undergoing Primary Total Knee Arthroplasty (AAOS 2026) - "Based on these findings, aspirin may be a suitable option for VTE prophylaxis in patients with visceral organ cancer that are undergoing primary TKA."

Clinical • Oncology • Orthopedics • Pain

Bleeding Disorders Are Not a Contraindication to Aspirin Prophylaxis in Patients Undergoing Primary Total Knee Arthroplasty (AAOS 2026) - "The findings of our study suggest that aspirin is a safe and effective method of VTE prophylaxis in patients with bleeding disorders that are undergoing primary TKA."

Clinical • Hematological Disorders • Orthopedics • Pain

Noninferiority of Aspirin to Other Anticoagulants for VTE Prophylaxis in Low Risk Patients Undergoing Aseptic Revision TKA (AAOS 2026) - "Aspirin is a safe, effective, and noninferior option for VTE prophylaxis following aseptic rTKA in appropriately selected patients."

Clinical • Head-to-Head

Antithrombotic Therapy and Their Association with Periprosthetic Joint Infection Risk after Total Knee Arthroplasty: A 12-Year Review (AAOS 2026) - "Over the past decade, aspirin has emerged as the most commonly used postoperative ATT agent following TKA and is associated with reduced risk of PJI."

Review • Infectious Disease • Orthopedics • Pain

Aspirin Is Noninferior to Other Anticoagulants for VTE Prophylaxis Following Aseptic Revision THA (AAOS 2026) - "Aspirin is a safe, effective, and noninferior option for VTE prophylaxis following aseptic rTHA in appropriately selected patients."

Chenodeoxycholic Acid (CDCA) Improves Biochemical Parameters in Patients with Cerebrotendinous Xanthomatosis (CTX) Presenting with Normal Cholestanol Levels (ACMG 2026) - " Case 1: A 3-month female presented with persistent neonatal cholestasis and was treated initially with ursodiol...He started CDCA 250 mg TID; aspirin was added to manage cardiovascular disease... CDCA treatment in cases 1 and 3 resulted in marked reduction of toxic plasma BA precursors and urinary bile alcohol levels, reflecting restoration of BA homeostasis. Additional data for all adult cases is forthcoming. While biochemical diagnosis of CTX traditionally relies on elevated plasma cholestanol, these atypical cases underscore the importance of assessing BA precursor and bile alcohol levels for diagnosis and therapeutic monitoring of CTX."

Clinical • Cardiovascular • Cataract • Cholestasis • Hepatology • Metabolic Disorders • Movement Disorders • Ophthalmology • ARG1 • CYP27A1

Postoperative Enoxaparin Versus Aspirin in Tibial Nailing of Closed Tibial Fracture: Equivalent Effects in Preventing Deep Vein Thrombosis (AAOS 2026) - "Aspirin is as effective as enoxaparin in the prevention of deep vein thrombosis and pulmonary embolism in patients treated with intramedullary nailing of closed tibial fracture."

Cardiovascular • Hematological Disorders • Musculoskeletal Diseases • Orthopedics • Pulmonary Embolism • Respiratory Diseases • Thrombosis • Venous Thromboembolism

Trends in the Utilization of Venous Thromboembolism Prophylaxis Following Hip Fracture from 2010 to 2023 (AAOS 2026) - "From 2010–2023, aspirin and DOAC use for VTE prevention after hip fracture surgery increased, while VTE rates declined slightly. LMWH remains the most commonly used prophylactic agent."

Cardiovascular • Musculoskeletal Diseases • Orthopedics • Venous Thromboembolism

Impact of Anticoagulation on Incidence of Manipulation under Anesthesia in Total Knee Arthroplasty (AAOS 2026) - "Aspirin is associated with lower rates of manipulation under anesthesia and postoperative hematoma compared to other common anticoagulants after primary total knee arthroplasty."

Anesthesia • Orthopedics • Pain

Aspirin Versus Potent VTE Chemoprophylaxis in Total Knee Arthroplasty: Reduced Postoperative Pain and Complications with Aspirin Use (AAOS 2026) - "TKA patients treated with potent VTEC versus aspirin experience more postoperative pain in the first 90-days and have an increased odds of stiffness requiring MUA."

Orthopedics • Pain