aspirin / Generic mfg. - LARVOL DELTA

Adjuvant aspirin for colorectal cancer with PIK3CA-mutated and COX-2 overexpressed tumours: the ASCOLT translational research study and meta-analysis. (PubMed, EBioMedicine) - P3 | "In ASCOLT TR, adjuvant aspirin was not associated with significantly improved DFS in CRC with PI3K-related mutations or COX-2 overexpression, albeit with wide confidence intervals. Combined results of the three published trials showed improved DFS among patients with PIK3CA exon 9/20 mutations. Moderate, but important, effects of aspirin in other patient groups have not been excluded."

Journal • Retrospective data • Colorectal Cancer • Oncology • Solid Tumor • PACERR • PI3K • PIK3CA • PTEN • PTGS2

Multi-Center Phase II Trial of Iberdomide and SQ Daratamumab as Post-ASCT Maintenance Therapy in Pts With Multiple Myeloma (the IBEX Trial): Initial Safety Analysis and Interim Efficacy Results. (IMS 2026) - "Lenalidomide (LEN) is standard maintenance therapy. Addition of an anti-CD38 antibody such as daratumumab (DARA) increases MRD(-) responses and further improves outcomes...All pts received aspirin unless anticoagulated... Post-ASCT maintenance with IBER plus DARA is feasible and safe. Neutropenia was manageable at the doses used in IBEX. Improvements in IMWG response and MRD conversion were observed despite pre-ASCT quadruplet induction."

Clinical • P2 data • Cardiovascular • Hematological Malignancies • Infectious Disease • Multiple Myeloma • Neutropenia • Respiratory Diseases • Targeted Protein Degradation • CRBN

Paediatric Adverse Event Signals Associated with OTC Cosmeceutical Skincare Ingredients in FAERS: A Pharmacovigilance Disproportionality Analysis Coinciding with the TikTok Skincare Boom (EADV 2026) - "Pharmaceutical confounders, including aspirin, isotretinoin, systemic tretinoin, corticosteroid combinations, prenatal vitamins and oncology formulations, were excluded. Findings support the need for age-specific skincare safety guidance, clearer paediatric labelling of cosmeceutical products and dermatologist-led public health education addressing TikTok-driven skincare behaviours in minors. The DiAna-based workflow provides a reproducible framework for ongoing surveillance of social media-driven cosmetic exposure trends."

Adverse events • Febrile Neutropenia • Hematological Disorders • Infectious Disease • Neutropenia • Pediatrics

Herbal and Natural Products for NSAID-Induced Small Intestinal Injury: a systematic review and meta-analysis of randomized controlled trials. (PubMed, J Pharmacopuncture) - "Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, are widely used medications that frequently cause small intestinal injury (enteropathy)...This study will synthesize the current clinical evidence on natural interventions for NSAID-induced enteropathy. The findings will inform the management of small intestinal injury and guide future research."

Journal • Retrospective data • Review

Successful Treatment of Impending Skin Necrosis Due to Nasal Arterial Occlusion Following Multiple Hyaluronic Acid Filler Injections by a Non-Physician Injector (EADV 2026) - "Adjunctive therapy included oral cefixime, cetirizine (10 mg/day), methylprednisolone (16 mg/day), and aspirin (100 mg/day), along with topical mupirocin and normal saline compresses.The patient was closely monitored on a daily basis, with no evidence of clinical deterioration. Early recognition of vascular compromise and immediate, aggressive management, particularly with timely administration of hyaluronidase, are essential to prevent irreversible tissue necrosis. Strengthening regulatory control and enhancing public awareness are crucial to minimizing such preventable complications."

Aesthetic Medicine • Dermatology

Left atrial appendage closure after a hospital admission for gastrointestinal bleeding in patients anticoagulated for atrial fibrillation. (PubMed, Rev Esp Enferm Dig) - "In real-world clinical practice, LAAC was infrequently used after hospitalization for GIB in anticoagulated patients with AF, being selectively reserved for specific clinical phenotypes. Nevertheless, this strategy was associated with a lower risk of adverse outcomes after adjusting for measured confounders. These findings should be interpreted cautiously given the observational design of the study."

Journal • Atrial Fibrillation • Cardiovascular • Gastroenterology

Apixaban in preventing portal vein thrombosis after laparoscopic splenectomy and azygoportal disconnection for cirrhosis: A single-arm trial. (PubMed, Surgery) - "Apixaban was associated with a lower risk of portal vein system thrombosis after laparoscopic splenectomy and azygoportal disconnection in cirrhotic patients compared with aspirin, suggesting its potential utility for prophylaxis in this population."

Journal • Cardiovascular • Fibrosis • Hematological Disorders • Immunology • Liver Cirrhosis • Portal Hypertension • Thrombosis

4-Point Cannula technique for Lip filler injection (EADV 2026) - "A full medical history specially intake of medications as aspirin, NSAIDS, Vit E supplements...They seek to have their filler injected using cannulas for other face areas as well. Results Conclusions"

Aesthetic Medicine • Dermatology

Comparative efficacy of AAC and ibuprofen versus lasmiditan, ubrogepant, and rimegepant for the acute treatment of episodic migraine in adults: a systematic review and network meta-analysis. (PubMed, Front Neurol) - "Compared with placebo, acetaminophen, aspirin, and caffeine (AAC) combination showed superior 2 h pain relief (RR, 1.76; 95% CI, 1.61-1.94; p-score = 0.96), followed by ibuprofen 400 mg and 200 mg. Larger trials and patient-level analyses are needed to refine efficacy, optimize dosing, and personalize migraine management. https://www.crd.york.ac.uk/PROSPERO/view/CRD420261325571, Identifier CRD420261325571."

Clinical • Journal • Retrospective data • Review • CNS Disorders • Migraine • Pain

Urolithin A has antiplatelet effects in contrast to its glucuronide, urolithin B, and isourolithin A. (PubMed, Front Cardiovasc Med) - "Combination experiments documented that urolithin can improve the antiplatelet effect of acetylsalicylic acid. Our observations suggest that urolithin A can be further investigated or used as a template for the development of antiplatelet drug(s). Additional pharmacokinetic, toxicological and efficacy studies are, however, required to confirm and quantify the extent of this effect in vivo."

Journal • Cardiovascular

Potential Role of Chronic Medication Use in Prurigo Nodularis: A Case–Control Study (EADV 2026) - "Most medication classes, including calcium channel blockers, angiotensin receptor blockers, angiotensin-converting enzyme inhibitors, thiazide diuretics, loop diuretics, beta blockers, insulin, dipeptidyl peptidase-4 inhibitors, metformin, sodium–glucose cotransporter-2 inhibitors, aspirin, and ADP receptor antagonists, did not differ significantly between groups. Conclusions Biopsy-confirmed prurigo nodularis was independently associated with chronic nonsteroidal antiinflammatory drug and antidepressant use compared with chronic pruritus controls. These findings support the importance of structured medication review during the clinical assessment of prurigo nodularis and warrant prospective studies to clarify temporality and underlying mechanisms."

Clinical • Cardiovascular • Diabetes • Dyslipidemia • Endocrine Disorders • Hypertension • Immunology • Metabolic Disorders • Prurigo Nodularis • Pruritus • Type 2 Diabetes Mellitus

Lymphocytic thrombophilic arteritis presenting with ulceration: a mimicker of livedoid vasculopathy and cutaneous polyarteritis nodosa (EADV 2026) - "She had previously been diagnosed with livedoid vasculopathy at another center and treated with rivaroxaban without clinical improvement...The patient was treated with low-dose aspirin and topical clobetasol propionate...Differentiating LTA from these entities is crucial, as livedoid vasculopathy represents a thrombotic vasculopathy and cutaneous polyarteritis nodosa a neutrophilic vasculitis, whereas LTA constitutes a distinct lymphocytic vasculitis, with important therapeutic implications. Increased awareness of this entity may help prevent misdiagnosis and unnecessary aggressive treatments."

Vasculitis

Moyamoya disease masquerading as CNS vasculitis: Diagnostic challenges and imaging insights. (PubMed, Qatar Med J) - "She improved clinically, was discharged on aspirin, and remained asymptomatic at neurosurgery follow-up...A structured, multimodal diagnostic approach is essential, particularly when imaging findings are atypical or potentially misleading. Early recognition and appropriate management can lead to favorable outcomes, as illustrated by our patient, who showed complete recovery and remained symptom-free on medical therapy."

Journal • Cardiovascular • CNS Disorders • Immunology • Pain • Vascular Neurology • Vasculitis

One Stone, Two Birds: Successful Treatment of Generalized Granuloma Annulare and Urticarial Vasculitis with Dupilumab (EADV 2026) - "Her medical history included goiter and cardiac arrhythmia, treated with levothyroxine, bisoprolol, propafenone, and aspirin...She had received systemic corticosteroids, methotrexate, hydroxicholoroquin and azathioprine; each for at least 3 months at different time points...Multiple treatments, including intralesional and systemic corticosteroids, narrowband UVB phototherapy with acitretin, omalizumab, and cyclosporine, were ineffective...(D) Conclusion Dupilumab demonstrated efficacy and safety in the management of generalized GA and urticarial vasculitis. To our knowledge, this is the first reported case of dupilumab successfully used in both conditions."

Cardiovascular • Dermatology • Endocrine Disorders • Immunology • Rare Diseases • Urticaria • Vasculitis • CD68

From Refractory Disease to Remission: Anifrolumab in Severe Discoid Lupus and Lupus Panniculitis (EADV 2026) - "Her treatment included hydroxychloroquine (200 mg daily), acitretin (25 mg daily), belimumab (from December 2021 to June 2025), low-dose aspirin, as well as topical corticosteroids and immunomodulators. She had also required multiple courses of systemic prednisone...Conclusion This case illustrates the successful use of anifrolumab in a patient with refractory cutaneous lupus, including severe discoid lupus erythematosus and lupus panniculitis, who had failed multiple systemic therapies such as acitretin and belimumab. Targeting the type I interferon pathway may represent an effective therapeutic strategy in recalcitrant cutaneous lupus, supporting the need for further studies to define its role in this subset of patients."

Clinical • Discoid Lupus Erythematosus • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Musculoskeletal Pain • Systemic Lupus Erythematosus • IFNAR2

Masked polycythaemia vera presenting with extensive splanchnic venous thrombosis and mesenteric ischaemia. (PubMed, BMJ Case Rep) - "We report a woman in her 60s with masked PV who had been managed for 5 years with intermittent phlebotomy and aspirin without haematology referral, molecular testing or cytoreductive therapy...Therapeutic anticoagulation was initiated with enoxaparin and subsequently transitioned to apixaban, while hydroxyurea achieved sustained haematologic control...Given ongoing portal hypertension, oesophageal varices, occasional mild ostomy bleeding and low body weight, anticoagulation was continued indefinitely at reduced intensity with apixaban 2.5 mg twice daily. At 21-month follow-up, the patient remained free of recurrent thrombosis and major bleeding."

Journal • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hypertension • Polycythemia Vera • Portal Hypertension • Thrombosis • Venous Thromboembolism • JAK2

Prostaglandin E2 Protects Against MRGPRX2/b2-mediated and Aspirin-aggravated Anaphylaxis via modulation of Mast Cell Activation. (PubMed, J Allergy Clin Immunol) - "Our findings demonstrate the protective role of PGE2 through mitigating MRGPRX2/b2-mediated anaphylaxis via a direct reduction of mast cell activation. Further studies are needed to clarify whether EP receptors may serve as therapeutic targets for preventing or modifying anaphylactic responses."

Journal • Immunology

Can we optimize the efficacy of aspirin for cardiovascular prevention? (PubMed, J Thromb Haemost) - No abstract available

Journal • Cardiovascular

EPIDEMIOLOGICAL, CLINICAL, AND BIOLOGICAL CHARACTERISTICS OF DRESSSYNDROME IN ELDERLY PATIENTS: A RETROSPECTIVE STUDY OF 21 CASES (EADV 2026) - "Allopurinol was the most frequently implicated drug (85.7%)...Other drugs included phenobarbital, an antibiotic, and aspirin (4.7% each)...Overall, DRESS in elderly patients shows clinical features similar to those in younger adults but appears to be associated with a higher frequency of visceral involvement, particularly renal. These findings highlight the need for careful prescribing practices and increased vigilance in elderly patients, as well as further studies focusing on this population."

Retrospective data • Cardiovascular • Diabetes • Eosinophilia • Gout • Hypertension • Inflammatory Arthritis • Metabolic Disorders

Pemphigoid-like bullous drug eruption associated with rivaroxaban: A case report (EADV 2026) - "Case Presentation A 76-year-old female patient with a history of hypertension treated with ramipril and acetylsalicylic acid and two previous cardioembolic ischemic strokes in 2021 and 2023, after which treatment was modified by the introduction of rivaroxaban and rosuvastatin, presented with a pruritic bullous skin eruption that appeared two months after initiation of the new medications, with preserved general condition...Management consisted of initiating topical therapy with very potent corticosteroids using clobetasol propionate 0.05% cream at an initial dose of 30 g/day with gradual tapering, combined with withdrawal of the suspected drug, rivaroxaban, which was replaced by apixaban in consultation with the cardiologist...The compatible temporal relationship, rapid improvement after rivaroxaban withdrawal, and absence of recurrence after more than one year support the probable involvement of rivaroxaban. This case underlines the need to consider pemphigoid-like..."

Case report • Clinical • Bullous Pemphigoid • Cardiovascular • Dermatopathology • Hypertension • Immunology • Ischemic stroke • Urticaria

From Analgesic to Adversary: Toxic Epidermal Necrolysis Caused by Nimesulide (EADV 2026) - "Corticosteroids and cyclosporine were gradually tapered. Follow-up CAST-ELISA testing for NSAIDs (lysine-acetylsalicylic acid, acetaminophen, diclofenac, and ibuprofen) was negative...This case illustrates the typical clinical course of SJS/TEN, demonstrating the importance of timely therapeutic intervention in preventing severe complications and achieving favourable outcomes. It also highlights the urgent need for clear, standardized treatment guidelines to ensure optimal management of these life-threatening conditions."

Alopecia • CNS Disorders • Conjunctivitis • Gastrointestinal Disorder • Infectious Disease • Migraine • Ocular Infections • Ocular Inflammation • Ophthalmology • Pneumonia • Respiratory Diseases • Steven-Johnson Syndrome

Type I cryoglobulinemic vaso-occlusion mimicking calciphylaxis: an important differential diagnosis in end-stage renal disease (EADV 2026) - "Treatment included methylprednisolone (1 mg/kg/day), aspirin (100mg/day), local warmth therapy, plasmapheresis for five days, and re-initiation of rituximab. Accurate diagnosis of cutaneous vasculopathy in dialysis-dependent patients requires integration of histopathology, systemic disease history, and prior therapy. Recognition of reactive angioendotheliomatosis as a marker of severe endothelial injury facilitates appropriate treatment, which may substantially affect prognosis."

Calciphylaxis • Cardiovascular • Complement-mediated Rare Disorders • Dermatopathology • Fibrosis • Gastroenterology • Glomerulonephritis • Heart Failure • Hematological Malignancies • Hepatology • Immunology • Infectious Disease • Influenza • Liver Cirrhosis • Lupus Nephritis • Monoclonal Gammopathy • Nephrology • Rare Diseases • Renal Disease • Respiratory Diseases • Thrombosis

Livedo racemosa after intra-articular hyaluronic acid injection confirmed by histopathology (EADV 2026) - "Conclusion This case highlights that iatrogenic vascular injury should be considered in the differential diagnosis of a painful reticulated eruption arising shortly after intra-articular hyaluronic acid injection. Histopathologic examination was critical for confirming hyaluronic acid embolization, and conservative treatment including aspirin may be a reasonable option in selected localized cases."

Immunology • Pruritus

Pleomorphic Dermal Sarcoma of the Posterior Cruris in an Elderly Woman Presenting as an Exophytic Noduloulcerative Lesion: An Uncommon Clinicodemographic and Anatomic Presentation (EADV 2026) - "The clinical appearance raised concern for a primary cutaneous malignancy; the differential diagnosis included squamous cell carcinoma, atypical fibroxanthoma, angiosarcoma, and metastatic disease.Her past medical history was significant for hypertension and prior coronary angiography; current medications included amlodipine, valsartan, and aspirin...Clinicians and pathologists should maintain a high index of suspicion for PDS when evaluating atypical ulcerated soft tissue lesions of the lower extremity, even in the absence of classic risk factors such as male sex or head and neck location. Multidisciplinary management including wide local excision and adjuvant radiotherapy remains the recommended approach for high-grade tumours."

Clinical • Angiosarcoma • Hypertension • Sarcoma • Skin Cancer • Solid Tumor • Squamous Cell Carcinoma • CD31 • CD34 • MME • PECAM1

Balancing Biologic Therapy and Tuberculosis Prophylaxis in Psoriasis: A Case of Suspected Ixekizumab–Isoniazid Cross-Reaction (EADV 2026) - "The patient was also receiving chronic treatment with perindopril/indapamide, sibutramine, and acetylsalicylic acid as part of her cardiovascular management. The occurrence of a suspected ixekizumab–isoniazid cross-reaction emphasizes the importance of close monitoring, particularly in the first hours following biologic initiation, multidisciplinary management and individualized therapeutic decision-making in patients with psoriasis. Reintroduction of ixekizumab after discontinuation of isoniazid proved safe and effective, leading to sustained clinical improvement."

Clinical • Atopic Dermatitis • Cardiovascular • Dermatology • Immunology • Infectious Disease • Inflammation • Plaque Psoriasis • Psoriasis • Respiratory Diseases • Tuberculosis • IL17A