AG011 / Precigen - LARVOL DELTA

Analysis of the effects of air pollutants and meteorological factors on upper respiratory tract infection outpatients in Gansu Province. (PubMed, Environ Sci Process Impacts) - "For NO2, the maximum RRs were 1.118 (95% CI: 1.022, 1.224) in Jiuquan (lag011) and 1.158 (95% CI: 1.104, 1.215) in Tianshui (lag011), while NO2 has no significant association in Dingxi...In Tianshui, the RRs are: PM2.5 (RR = 1.090, 95% CI: 1.058, 1.124), PM10 (RR = 1.043, 95% CI: 1.024, 1.062), NO2 (RR = 1.180, 95% CI: 1.115, 1.248), and CO (RR = 1.894, 95% CI: 1.631, 2.210). In conclusion, both air pollutants and meteorological factors had an influence on URTI outpatient visits, and the influence on URTI outpatient visits may have an interaction."

Journal • Infectious Disease • Respiratory Diseases • LAG3

Short-term effects of ambient air pollution on influenza incidence in Chongqing, China: a time-series analysis. (PubMed, Int J Environ Health Res) - "In multi-day lag models, changes peaked at lag011-014. Stratified analyses revealed children aged 0-14 years as particularly vulnerable during the cold season and COVID-19 period. The study demonstrates that short-term lags and cumulative effects of air pollution exposure increase influenza incidence, significant for establishing influenza response strategies."

Journal • Infectious Disease • Influenza • Novel Coronavirus Disease • Respiratory Diseases

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Early Neuronal Accumulation of DNA Double Strand Breaks in Alzheimer’s Disease (AAIC 2019) - "Our study demonstrates that neuronal DSBs accumulate from early stages of AD pathology, raising the possibility that this process causally contributes to cellular dysfunction and cell death in AD. Our finding that pan-nuclear increases in gammaH2AX formation can result from increases in neuronal activity and do not represent DSBs highlight the pitfalls of using total gammaH2AX levels as a proxy for DSBs, and may help resolve some conflicting findings in the literature regarding DSBs in AD. Supported by NIH grants AG011385 and AG053981."