allogeneic BM-MSCs / Mayo Clinic - LARVOL DELTA

Intra-articular delivery of allogeneic bone marrow derived mesenchymal stromal cells (BM-MSCs) for painful lumbar facet arthropathy: a phase I clinical trial. (PubMed, Stem Cell Res Ther) - P1 | "This study demonstrated a favorable safety profile for intra-articular delivery of BM-MSCs for painful LFA. Preliminary therapeutic benefits were observed, including back pain relief, improved physical function, and reduced facet joint degeneration. Further larger, randomized clinical trials are warranted to further assess its safety and efficacy. Trial Registration ClinicalTrials.gov Identifier: NCT04410731."

Clinical • Journal • P1 data • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain • Rheumatology

Cellkine: Allogeneic BM-MSCs in Patients with Lumbar Facet Arthropathy (clinicaltrials.gov) - P1 | N=10 | Completed | Sponsor: Mayo Clinic | Active, not recruiting ➔ Completed | Trial completion date: Oct 2024 ➔ Mar 2024 | Trial primary completion date: Oct 2024 ➔ Mar 2024

Trial completion • Trial completion date • Trial primary completion date • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain • Rheumatology

CellKine clinical trial: first report from a phase 1 trial of allogeneic bone marrow-derived mesenchymal stem cells in subjects with painful lumbar facet joint arthropathy. (PubMed, Pain Rep) - "This patient also reported improvements in mental and social health, along with a notable improvement in the grade of facet synovitis observed at the one-year follow-up MRI evaluation. This case report suggests the safety and feasibility of administering intra-articular allogeneic BM-MSCs, offering therapeutic benefits for pain management and functional activities."

Journal • P1 data • Back Pain • Lumbar Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Pain • Rheumatology

Cellkine: Allogeneic BM-MSCs in Patients With Lumbar Facet Arthropathy (clinicaltrials.gov) - P1 | N=10 | Active, not recruiting | Sponsor: Mayo Clinic | Trial completion date: Apr 2024 ➔ Aug 2024 | Trial primary completion date: Apr 2024 ➔ Aug 2024

Trial completion date • Trial primary completion date • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain • Rheumatology

Cellkine: Allogeneic BM-MSCs in Patients With Lumbar Facet Arthropathy (clinicaltrials.gov) - P1 | N=10 | Active, not recruiting | Sponsor: Mayo Clinic | Recruiting ➔ Active, not recruiting | Trial completion date: Apr 2022 ➔ Apr 2024 | Trial primary completion date: Apr 2022 ➔ Apr 2024

Enrollment closed • Trial completion date • Trial primary completion date • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain • Rheumatology • CRP

Cellkine: Allogeneic BM-MSCs in Patients With Lumbar Facet Arthropathy (clinicaltrials.gov) - P1; N=10; Recruiting; Sponsor: Mayo Clinic; Trial completion date: Jul 2021 ➔ Apr 2022; Trial primary completion date: Jul 2021 ➔ Apr 2022

Clinical • Trial completion date • Trial primary completion date • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain • Rheumatology • CRP • MRI

Cellkine: Allogeneic BM-MSCs in Patients With Lumbar Facet Arthropathy (clinicaltrials.gov) - P1; N=10; Recruiting; Sponsor: Mayo Clinic; Trial completion date: Dec 2020 ➔ Jul 2021; Trial primary completion date: Dec 2020 ➔ Jul 2021

Clinical • Trial completion date • Trial primary completion date • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain • Rheumatology • CRP • MRI

Cellkine: Allogeneic BM-MSCs in Patients With Lumbar Facet Arthropathy (clinicaltrials.gov) - P1; N=10; Recruiting; Sponsor: Mayo Clinic; Active, not recruiting ➔ Recruiting

Clinical • Enrollment open • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain • Rheumatology • CRP