resveratrol (GSK184072) / GSK - LARVOL DELTA

Quantitative Analysis of Factors Regulating Angiogenesis for Stem Cell Therapy. (PubMed, Biology (Basel)) - "Resveratrol and quercetin enhanced the expression of PPARγ, and luteolin suppressed the expression of COX-1...(4) We showed the promoting effect of Ang-1 or DFAT and the suppressing effect of polyphenols on angiogenesis and studied their molecular mechanisms. These results help control angiogenesis in regenerative therapy."

Journal • ANGPT1 • CD31 • NOS3 • PPARG

Red Wine Antioxidant Supplements Don’t Help Obese Men (Eminetra) - "Dr. Howard Weintraub...said that was good advice. 'Wine has advantages over resveratrol, partly because alcohol helps improve good cholesterol, he said. 'If you enjoy red wine, one or two glasses a day may be beneficial'. But he warned, more is better just because one or two glasses may be good for you. It does not mean that."

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"13:36, OK, Jeff Hodges? While you are playing w/ LOST @TheRTP, @GSK Jobs & Assets for @UNC Mebane Park & Ride Hospital? GENTLEMEN? Back to the Future w/ Resveratrol @VeteransHealth https://t.co/IGJhXgoxK5 & @NIH https://t.co/38kifX758j Thank you @JimInhofe https://t.co/xoSZXzg6cX" (@MHolland_VA)

Clinical

"awesome compound if you are a mouse. @GSK spent billions on SRT501 without seeing efficacy in human beings" (@CharlesMBrenner)

Preclinical

"You are confused because @charlesmbrenner is dishonest. He helped sell resveratrol to @GSK back in the day and his prof jealousy of @davidmsinclair has led to anti resveratrol campaign now." (@chardonnayaok2)

Shousha, Naglaa Zayed, Mahmoud N El-Rouby, Ahmed O Kaseb, Ashraf - "...Ahmed O. Kaseb...Veliparib Hydrophobic bile acids, such as deoxycholic acid (DCA), are know to modulate the expression of several apoptosis-related proteins, including c-Jun N-terminal kinase (JNK), leading to cell death. In addition, microRNAs (miRNAs or miRs) are being increasingly implicated in cell death and in the pathogenesis of human liver diseases."

"Would it be "unkind" to point out @CharlesMBrenner was on board of company that sold @GSK #resveratrol? #hypocrite" (@chardonnayaok2)

"Reminds me of the ppl who sold resveratrol to @GSK for $720 m" (@CharlesMBrenner)

"No and resveratrol is water soluble and not particularly lipophilic — it’s expensive pee. Ask @GSK" (@CharlesMBrenner)

"we were happy that our horses were not hitched to that wagon. The concept that @GSK bought w respect to resveratrol & other so-called STACs was a house of cards. Resveratrol not a STAC & underlying SIRT lore based on overinterpreted, overhyped & nonreproducible experiments. /11" (@CharlesMBrenner)

Why isn’t resveratrol being used after every heart attack, & in all cases of angina chest pain with or without coronary artery stent? - "As Milton Packer MD states: 'The results of the (ORBITA) trial threatened the livelihoods of thousands of interventional cardiologists… they criticized the trial with a vengeance,' they have placed the ORBITA trial 'into the dustbin of history.'"

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