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Beyond the Bloodstream: Gastrointestinal Involvement in Idiopathic Hyper-Eosinophilic Syndrome (ACG 2025) - "A CT scan of the abdomen and pelvis showed dilated, fluid-filled loops of the small bowel, multiple thickened small bowel loops, ascites, and small bilateral pleural effusions.Despite empiric treatment with albendazole initiated by the infectious disease team, her eosinophil count continued to rise. She exhibited a dramatic decrease in WBC count from 42 (79% eosinophils) in the morning to 17 (65.8% eosinophils) by the afternoon, and further to 11 (2.4% eosinophils) the following day, with marked improvement in her symptoms. The patient was then transitioned to a tapering dose of steroids, along with an antihistamine, an H2 blocker, and an anti-IL-5 antibody. Hypereosinophilic syndrome (HES) is diagnosed when hypereosinophilia is accompanied by tissue damage and other potential causes of eosinophilia or tissue damage are excluded.HES with primary gastrointestinal eosinophilic diseases (EGIDs) is rare, with only 34 reported cases.we report a 25-year-old female with..."

Asthma • Dermatology • Eosinophilia • Food Hypersensitivity • Hematological Disorders • Hypereosinophilic Syndrome • Immunology • Infectious Disease • Respiratory Diseases • IL5

Does Albendazole Play a Role in Preventing Lung Hydatidosis Relaps? (ERS 2025) - No abstract available

Pulmonary Disease • Respiratory Diseases

Renal hydatid cyst: diagnostic and treatment considerations (ECP 2025) - "Treatment options include surgery (partial or total nephrectomy), percutaneous drainage, and antiparasitic therapy with albendazole... This case underscores the rare presentation of renal hydatid cysts and emphasizes the importance of early diagnosis to prevent severe complications such as rupture or infection. Accurate identification through imaging and serological tests is crucial, and timely treatment significantly improves patient outcomes."

Infectious Disease • Kidney Cancer • Ocular Melanoma • Renal Cell Carcinoma • Solid Tumor • Urology

Unusual hydatid cysts: 5 cases report with heart, brain, kidney, muscle and bone localization (ECP 2025) - "The disease may have many different clinical presentations. The widespread use and development of imaging methods such as CT and MRI make our job easier in diagnosis. Although it is a benign disease, sometimes it can cause serious morbidity and even mortality."

Case report • Clinical

Pharmacological evaluation on benzimidazole anthelmintics for eradication of the gill fluke Microcotyle sebastis infesting a black rockfish, Sebastes schlegelii. (PubMed, Vet Parasitol) - "This study comprehensively evaluated the in vitro and in vivo anthelmintic efficacy and pharmacokinetics of four benzimidazole compounds: febantel (FB), fenbendazole (FBZ), albendazole (ABZ), and mebendazole (MBZ) against the gill fluke Microcotyle sebastis in cultured black rockfish (Sebastes schlegelii). These findings highlight ABZ as the most efficacious compound, with FB showing promise through metabolic conversion to FBZ, and MBZ demonstrating limited efficacy due to poor absorption and rapid inactivation. Overall, this study provides an integrated evaluation of both efficacy and pharmacokinetics, indicating that ABZ and FB are effective candidates for managing M. sebastis infections in aquaculture."

Journal • Infectious Disease

Critical dysregulated signaling pathways in drug resistance: highlighting the repositioning of mebendazole for cancer therapy. (PubMed, Front Pharmacol) - "Mebendazole (MBZ), albendazole, flubendazole, and oxfendazole are broad-spectrum anti-helminthic drugs from the benzimidazole family. While the anticancer effects of MBZ are encouraging, further research is needed before it can be used clinically. Extensive data from in vitro, in vivo, and clinical trials support MBZ's anticancer potential and highlight the need for innovative delivery methods, including polymeric nanoparticles, nanostructured lipid formulations, micelles, nanosuspensions, and beyond."

Journal • Review • Oncology

Endoscopy in the Diagnosis of Anemia (ACG 2025) - "The treatment of choice for hookworm infection is albendazole (400mg) or mebendazole (500mg) administered orally for 3 days for maximum effectiveness, with iron and nutritional support. This case demonstrates the necessity to suspect hookworm infection in IDA patients even when stool tests are negative and shows how prevention efforts fail to address zoonotic transmission. The control of soil-transmitted helminthiasis requires regular deworming programs together with veterinary interventions in areas where the disease is endemic and to prevent its long term morbidity calls for public health strategies that combine education with sanitation improvements and multisectoral collaboration.Figure: Parasitic worm located in the descending part of the second part of duodenum.Figure: Parasitic worms located in the ampullary region of the second part of duodenum."

Anemia • Anorexia • Eosinophilia • Fatigue • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease • Pulmonary Disease

Pinworm Found During Screening Colonoscopy (ACG 2025) - "The main medications used are albendazole, mebendazole, or pyrantel pamoate. The are no estimates of the prevalence of pinworms found during routine colonoscopy.Figure: Figure 1. Small worms in the cecum near the appendiceal orifice."

Colorectal Cancer • Infectious Disease • Pruritus • Solid Tumor

A Squirmy Surprise: Enterobiasis vermicularis Treatment in Pregnancy (ACG 2025) - "Pyrantel pamoate is preferred to albendazole and mebendazole due to poor systemic absorption limiting fetal exposure. In order to prevent reinfection, hygienic measures should be implemented to include washing bedsheets, fingernail clipping and, frequent handwashing. Due to the endemic nature of pinworms and their potential complications, physicians need greater awareness and understanding on treatment in pregnancy.Figure: Pinworm in rectumFigure: Pinworm in sigmoid colon"

Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Pruritus

Unmasking the Cause: A Rare Case of Idiopathic Hypereosinophilic Syndrome in a Young Male Presenting with Symptoms of Gastroenteritis (ACG 2025) - "Systemic corticosteroids (prednisone 20 mg TID) were then initiated, resulting in rapid clinical and laboratory improvement: WBC decreased to 12.43 × 10³/μL and AEC to 2.61 × 10³/μL...Albendazole has been effective in treating parasitic causes of eosinophilia, but our patient failed to respond until corticosteroids were initiated...Overall, this case highlights IHES as a rare but important differential diagnosis in patients presenting with GI symptoms and marked eosinophilia. Figure: Figure 1: CT abdomen and pelvis showing nonspecific fluid in pelvis."

Clinical • Cardiovascular • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Hypereosinophilic Syndrome • Immunology • Rare Diseases

Unmasking the Biliary Trap: Diagnostic and Therapeutic Challenges of Cysto-Biliary Communication in Hepatic Hydatid Disease (ACG 2025) - "Albendazole was initiated preoperatively...C. Histopathology - High power: Highlights crescent-shaped, eosinophilic, chitinous hooks of E. granulosus protoscolices arranged in a diagnostic double row."

Anorexia • Cardiovascular • CNS Disorders • Diabetes • Fibrosis • Hematological Disorders • Hypertension • Infectious Disease • Metabolic Disorders

The Hidden Culprit: Abdominal Pain Secondary to Parasitic Infection (ACG 2025) - "The patient was treated with albendazole 400mg PO daily for 3 days...A high index of suspicion for parasitic infections in the appropriate clinical context is essential to ensure timely diagnosis and management.Figure: Figure 1. Colonoscopy images of cylindrical, off-white worms at cecum."

Anemia • Crohn's disease • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Inflammatory Bowel Disease • Pain • Peptic Ulcer • Pruritus

Schistosomiasis or Ulcerative Colitis? Unraveling the Overlap Between Parasitic Infection and IBD (ACG 2025) - "He was started on mesalamine and prednisone...Symptom improvement following praziquantel and albendazole may reflect parasite clearance, but concurrent steroid use makes it unclear whether recovery was due to anti-parasitic therapy, immunosuppression, or both...Endoscopic image of the rectum showing continuous moderate inflammation consistent with ulcerative colitis, with loss of vascular pattern, erythema, friability, and superficial ulcerations (Mayo 2).Figure: Figure 2. Left colon biopsy: Colonic mucosa with increased lamina propria eosinophils, eosinophilic microabscess, and parasite ova/larva."

Dermatology • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

Trichuris Causing Severe Iron Deficiency Anemia in an Adult in a Non-Endemic Area (ACG 2025) - "She completed albendazole therapy but was unable to access ivermectin due to insurance limitations...TDS in adults is rare with the majority having no to minimal non specific abdominal symptoms such as abdominal pain, diarrhea, occult bleeding, and IDA is usually the reason for endoscopic evaluation which shows large parasite infestation confirming the diagnosis. A broader differential, cultural competence, and attention to healthcare access can guide appropriate workup and management.Figure: Colonoscopy showing internal hemorrhoids, a lipoma, and parasite-Trichuris"

Clinical • Anemia • Cardiovascular • CNS Disorders • Diabetes • Endocrine Disorders • Eosinophilia • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Hematological Disorders • Hypertension • Infectious Disease • Mental Retardation • Metabolic Disorders

Chronic Strongyloidiasis Presenting With Severe Sepsis and Hemorrhagic Enteritis: A Case Report (ACG 2025) - "Treatment with ivermectin was started for 1 month and albendazole for 7 days for severe disease...Thus a high level of clinical suspicion is necessary for prompt diagnosis and treatment of these cases to reduce mortality rates.Figure: Low power gastric mucosa with parasites. Figure: Duodenal image of duodenitis."

Case report • Clinical • Anemia • Cardiovascular • Chronic Kidney Disease • Dermatology • Diabetes • Eosinophilia • Gastrointestinal Disorder • Hematological Disorders • Hypotension • Infectious Disease • Metabolic Disorders • Nephrology • Pneumonia • Pulmonary Arterial Hypertension • Pulmonary Disease • Renal Disease • Respiratory Diseases • Septic Shock

The Hidden Worms: Colonoscopy as a Key Diagnostic Tool for Parasitic Infestation (ACG 2025) - "He was treated with Albendazole 400 mg for 3 days, with notable symptom improvement and hemoglobin stabilization to 8 g/dL...Its role is particularly critical in diagnosing parasitic infections when standard stool analyses fail, as demonstrated in this case. In patients with negative stool studies but high clinical suspicion, colonoscopy is critical for timely diagnosis and effective management.Figure: Colonoscopy showing a live adult Trichuris trichiura attached to the cecal mucosa."

Anemia • Gastroenterology • Hematological Disorders • Infectious Disease

Stringy Deception: Rare Case of Pseudoparasitosis (ACG 2025) - "Given her distress, she was prescribed an empiric course of albendazole while emphasizing the negative test results...Second generation antipsychotics have shown efficacy of up to 70% in treating this condition, however high relapse rates (30%) emphasize care be taken to maintain patient trust and follow up. While controversial, our approach utilizing empiric antiparasitics while reinforcing negative workup helped maintain the therapeutic alliance with our patient while transitioning to psychiatric care."

Clinical • CNS Disorders • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Mood Disorders • Nicotine Addiction • Psychiatry • Rare Diseases

Misdiagnosed Mass: A Case of Trauma and Hidden Parasites (ACG 2025) - "Antiparasitic therapy with albendazole is necessary. Preoperative treatment with benzimidazoles is recommended to lower intracystic pressure and reduce the risk of rupture during cyst removal.Figure: Image A. CT scan of the abdomen showing a mass of 62 mmFigure: Image B. MRI of the abdomen showing the walled-off cyst"

Clinical • Gastrointestinal Disorder • Infectious Disease • Mood Disorders • Peptic Ulcer

Double Trouble: Unmasking Parasitic Colitis Mimicking Inflammatory Bowel Disease (ACG 2025) - "Despite absent eosinophilia, serology testing and biopsy-confirmed diagnosis prevented mismanagement and treatment with albendazole and praziquantel led to significant improvement, underscoring the need for early recognition and appropriate therapy.Figure: Images of the transverse colon reveal stricture and ulcerating disease. Stricture also present in splenic flexure, as well as a friable ileo-cecal valve."

Anemia • Autoimmune Hepatitis • Cardiovascular • Eosinophilia • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Liver Cirrhosis • Portal Hypertension

Perils of Parasitism: A Novel Endoscopic Diagnosis of Severe Iron Deficiency Anemia (ACG 2025) - "The patient was treated with a 400 mg dose of albendazole, resulting in resolution of symptoms and normalization of hemoglobin to 14.0 g/dL at a two-month follow-up visit. This case highlights the importance of considering hookworm infection in the differential diagnosis of iron-deficiency anemia, particularly in individuals from endemic areas...Ancylostoma duodenale in the duodenumFigure: Figure 2. Ancylostoma duodenale in the cecum"

Anemia • Eosinophilia • Gastroenterology • Hematological Disorders • Infectious Disease • Inflammation • Mucositis

Beyond IBS: An Unusual Case of Eosinophilic Gastroenteritis (ACG 2025) - "Conservative management was started, infectious disease recommended treatment with a dose of oral albendazole 400 mg and ivermectin 200 mcg/kg...Given the negative infectious workup, we initiated prednisone 20 mg with a taper over four weeks...This represents an important functional cause of obstruction. We highlight how corticosteroids can be beneficial after completing a hematology-oncology workup and ruling out infectious causes."

Clinical • Constipation • Eosinophilia • Eosinophilic Esophagitis • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Rare Diseases

Suspected Familial Hypertrophic Cardiomyopathy in a 13-Year-Old Male From an Underserved Region of the Dominican Republic: A Case Report. (PubMed, Cureus) - "Treatment consisted of ivermectin and albendazole for parasitic infection, a multivitamin for nutritional support, and a referral to pediatric cardiology for workup. Here, we describe the challenges of care in an international setting, the importance of gathering a solid history and physical examination, and the disparities associated with hypertrophic cardiomyopathy in underserved communities. This case highlights the importance of access to high-quality healthcare services in underdeveloped and underserved countries to increase patient longevity, improve health equity, and reduce morbidity."

Journal • Cardiomyopathy • Cardiovascular • Hypertrophic Cardiomyopathy • Infectious Disease • Pain • Pediatrics

Prevalence & determinants of soil-transmitted helminth infection among 1-15 year-olds in a tribal-dominated district of Odisha, India. (PubMed, Indian J Med Res) - "Identifying the prevalent risk factors, developing multi-prong integrated strategies could be effective in preventing and controlling STH infection in these areas. The interventions need to focus on improving awareness on STH, ensuring hygiene and sanitation practices and compliance to biannual administration of albendazole under health programmes."

Journal • Infectious Disease

Subarachnoid Neurocysticercosis Caused by Larval-Stage Taenia crassiceps Tapeworm, Slovenia. (PubMed, Emerg Infect Dis) - "The parasite was identified by 12S rDNA PCR and sequencing. Despite prolonged therapy with albendazole and praziquantel, the disease recurred after treatment was discontinued."

Journal • CNS Disorders • Infectious Disease

Long-Term Neuroimaging Findings in a Murine Model of Human Extraparenchymal Neurocysticercosis. (PubMed, ACS Infect Dis) - "Current treatment involves cysticidal drugs (albendazole and/or praziquantel) combined with glucocorticoids to manage the associated neuroinflammation; however, only ∼30% of patients respond effectively. MRI confirmed NCC in 77% of infected rats, all exhibiting extraparenchymal localization and persistently elevated levels of HP10, a marker of viable cysticerci. Imaging also enabled precise cyst localization and estimation of the parasite-occupied volume."

Journal • Preclinical • Infectious Disease • Inflammation