albendazole / Generic mfg. - LARVOL DELTA

Effect of apatinib on albendazole metabolism in vitro and in vivo. (PubMed, Bioorg Chem) - "For the metabolites albendazole sulfoxide and hydroxyalbendazole, apatinib caused significant increases in AUC(0-t), AUC(0-∞), and Tmax, while a significant decrease in CLz/F. In summary, apatinib could inhibit the metabolism of albendazole in vitro and in vivo, so albendazole should be closely monitored for adverse effects when used in combination with apatinib and discontinued if necessary."

Journal • Preclinical • Oncology • CYP3A4

Cardiac Hydatid Cyst: A Diagnostic and Therapeutic Challenge Requiring a Multidisciplinary Approach. (PubMed, JACC Case Rep) - "Cardiac hydatid cysts, although exceptional, should be suspected in patients from endemic regions presenting with intracardiac masses. Negative serologic results do not exclude the diagnosis. Echocardiography and cardiac magnetic resonance imaging are key for diagnosis and surgical planning. Long-term follow-up is mandatory because of the risk of recurrence, even after complete resection."

Journal • Pain • Pulmonary Disease

Toxocariasis in Internationally Adopted Children: Seroprevalence, Diagnostic and Therapeutic Strategies: Toxocariasis in Internationally Adopted Children. (PubMed, Int J Infect Dis) - "Approximately one in six internationally adopted children shows Toxocara spp. seropositivity. While IgG-TES ELISA is a sensitive screening tool, confirmatory Western blot substantially improves specificity and diagnostic stewardship, reducing unnecessary second-level investigations. A substantial proportion of seropositive children likely represent clinically inactive seropositivity, for which it is not possible to differentiate recent infection from past exposure to the parasite. Integrating serology with eosinophil counts, IgE levels, and clinical assessment is crucial to distinguish active from resolved infection and to identify children who require clinical and instrumental follow-up and albendazole therapy, thereby avoiding unnecessary interventions."

Journal • Eosinophilia • Infectious Disease

Insights from a fatal case of disseminated albendazole refractory Annacaliia algerae myositis (ESCMID Global 2026) - No abstract available

Clinical • Immunology • Myositis

Albendazole pharmacokinetics in plasma and cystic tissue of human cystic and alveolar echinococcosis (ESCMID Global 2026) - No abstract available

PK/PD data

The Death to Onchocerciasis and Lymphatic Filariasis (DOLF) project: Accomplishments and ongoing research. (PubMed, PLoS Negl Trop Dis) - "More recently, we have shown that single-dose treatment with moxidectin plus albendazole is superior to the ivermectin plus albendazole regimen currently recommended for LF elimination in Africa. DOLF has also addressed the issue of MDA compliance, because improved treatments cannot be effective if people do not swallow the tablets. We highlight here some of DOLF's important discoveries that support the control and elimination of neglected tropical diseases caused by helminths."

Journal • Review • Infectious Disease • Ophthalmology

Poor Response to Albendazole in Hookworm-Infected Abnormal Haemoglobin Carriers. (PubMed, Trop Med Int Health) - "These findings suggest that abnormal haemoglobin may be a host factor contributing to low albendazole efficacy in treating hookworm infections."

Journal • Infectious Disease

Cystic echinococcosis in patients with leukemia: Clinical challenges and review of reported cases. (PubMed, IJID Reg) - "One patient had chronic lymphocytic leukemia and a hepatic CE2 cyst managed with albendazole and surgery before chemoimmunotherapy, and another patient had B-cell acute lymphoblastic leukemia and prior hepatic and pulmonary CE treated with concurrent albendazole and induction chemotherapy...A literature review identified only a few cases, mostly acute myeloid leukemia, and none from Latin America. These cases highlight therapeutic dilemmas in balancing infection control and malignancy treatment, underscoring the need for tailored management strategies in endemic regions."

Journal • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • B Acute Lymphoblastic Leukemia • Chronic Lymphocytic Leukemia • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Oncology

Potential of secondary metabolite compounds of sweet potato (Ipomoea batatas) leaves as anthelmintic against Haemonchus contortus. (PubMed, Open Vet J) - "was almost as effective as 2 mg/ml albendazole after 3 hours and equal after 4 hours...exhibited anthelmintic effects against H. contortus. Ultrastructural changes were observed on the rough, wrinkled surface with irregular cuticle structure and the occurrence of damage, indicating that the anterior and posterior cuticle structures were vulnerable."

Journal

Hepatic cystic echinococcosis in a low-endemic region, Denmark. (PubMed, IDCases) - "The patient was commenced on albendazole and underwent a minimal invasive percutaneous procedure. Repeated CT images months later detected decreased size of the lesions without evidence of recurrence. This case highlights the importance of considering E. granulosus as a differential diagnosis in cystic liver lesions, even in patients without obvious exposure."

Journal • Anorexia • Fatigue • Hepatology • Infectious Disease • Oncology • Pain

Point-of-Care Ultrasound Identification of Motile Enterobius vermicularis in the Appendix of a Toddler: The Youngest Reported Case and Successful Nonoperative Management of Early Appendicitis. (PubMed, Pediatr Emerg Care) - "True intraluminal motility is a critical sonographic discriminator of parasitic infestation and can fundamentally alter management decisions. In this case, early identification of E. vermicularis supported a safe, nonoperative strategy for early appendicitis. Incorporating POCUS early in the evaluation of atypical pediatric abdominal pain may prevent unnecessary surgical intervention."

Journal • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Pain • Pediatrics

Research Project on the Prevention and Control of Clonorchiasis (Subproject 1: Comparative Study on the Therapeutic Efficacy of Anthelmintic Drugs against Clonorchiasis) (ChiCTR) - P4 | N=567 | Recruiting | Sponsor: The People’s Hospital of Guangxi Zhuang Autonomous Region; The People’s Hospital of Guangxi Zhuang Autonomous Region

New P4 trial

Multicenter Cross-Sectional Study on Pharmacotherapeutic Regimens for Clonorchiasis in Guangxi: Focus on Clinical Application Status of Albendazole and Praziquantel (ChiCTR) - P=N/A | N=650 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Guangxi Medical University; The First Affiliated Hospital of Guangxi Medical University

New trial

Thereaputic efficacy of single dose Albendazole against Ascaris lumbricoides, prevalence of re-infection, and its associated factors among school children at Northwest Ethiopia: an open-label trial study. (PubMed, BMC Infect Dis) - No abstract available

Journal • Infectious Disease

Moxidectin for LF, Cote d'Ivoire (DOLF) (clinicaltrials.gov) - P3 | N=164 | Completed | Sponsor: Washington University School of Medicine | Active, not recruiting ➔ Completed

Trial completion

Coacervated and Freeze-Dried Polysaccharides-Nanoparticle with Efficient Encapsulation of Albendazole for High-Performance Treatment of Monogenean Parasite Infestation in Tilapia Fish. (PubMed, Int J Mol Sci) - "The treatment of 100% prevalence of monogeneans was effective with a six-day dosage providing a total of 915 mg/kg b.w. of drug, resulting in total parasite clearance after 10 days from the treatment beginning, evidenced by microscopy analysis, and no mortality occurred. Therefore, molecular interactions between biofriendly polyelectrolytes yielded albendazole-carrying nanoparticles for high-efficiency parasite treatment in fish farming."

Journal

A Sustainable Strategy for Gastrointestinal Nematode Control in Sheep. (PubMed, Vet Sci) - "This study compared two parasite control strategies in Zerasca sheep: routine albendazole treatment administered twice yearly (T) and a long-term non-chemical approach based on rotational grazing (relocation to a new pasture when grass height fell below 10 cm) combined with quarterly veterinary monitoring (NT)...Hair cortisol concentrations did not differ significantly between groups. Overall, these findings suggest that a non-chemical parasite management strategy, when combined with controlled grazing and veterinary monitoring, may maintain acceptable parasite levels while supporting body condition and stable welfare indicators, potentially reducing reliance on routine anthelmintic treatments."

Journal • Hematological Disorders

Ultrastructural Evaluation (SEM) of Ascaris lumbricoides Eggs Treated with Silver Nanoparticles Biosynthesised by Duddingtonia flagrans Using Scanning Electron Microscopy (SEM). (PubMed, Pathogens) - "The combined treatment with AgNPs and albendazole resulted in severe degradation. These findings demonstrate that AgNPs exhibit significant ovicidal activity and may serve as effective adjuvants to enhance the action of conventional anthelmintics against highly resistant helminth eggs."

Journal

Primary Subcutaneous Hydatid Cyst of the Abdominal Wall in a Child: A Case Report and Literature Review. (PubMed, Cureus) - "The lesion was completely excised through a right iliac fossa approach without intraoperative complications, and albendazole therapy was administered. A review of the literature identified only a small number of abdominal wall hydatid cysts located in the subcutaneous tissue, with very few paediatric cases and most associated with concomitant visceral disease. This case illustrates that hydatid disease should be considered in the differential diagnosis of any subcutaneous cystic mass in patients from endemic areas, even in the absence of hepatic or pulmonary involvement."

Journal • Infectious Disease • Pain • Pediatrics

Core-shell heterostructured nanozyme for alveolar echinococcosis treatment via targeted electron transfer and catalytic reactive oxygen species generation. (PubMed, J Colloid Interface Sci) - "Alveolar echinococcosis (AE), a severe parasitic disease, poses a significant therapeutic challenge due to the limitations of surgery and albendazole chemotherapy, particularly the difficulty in achieving targeted drug delivery and disrupting the robust structure of the protoscoleces (PSCs)...The subsequent interfacial ET from FZ-2 disrupts the PSCs' membrane potential, leading to lethal osmotic imbalance and a high efficacy (98%) in inducing PSCs death. This work not only provides a potent nanomedicine for AE but also establishes a pioneering ET-based therapeutic paradigm for treating diseases with complex multicellular barriers."

Biomarker • Clinical • Journal • Observational data • Preclinical • Retrospective data • Review

Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH) (clinicaltrials.gov) - P3 | N=357716 | Completed | Sponsor: University of Washington | Active, not recruiting ➔ Completed

Trial completion

Unusually Extensive Furuncular Myiasis in a Returning Traveller from Rural Ethiopia Complicated by Streptococcus Pyogenes Secondary Infection Following Albendazole Therapy. (PubMed, Reports (MDPI)) - "Clinicians should maintain a high index of suspicion for myiasis in patients with compatible cutaneous lesions and relevant history. Increasing travel and shifting vector distributions make familiarity with tropical dermatoses and provision of effective safety measures essential in clinical practice."

Journal • Dermatology • Infectious Disease

Effectiveness of eprinomectin, albendazole and their combination therapy against strongyle nematode in dairy goats: A clinical field study using nemabiome-integrated approach in Thailand. (PubMed, Curr Res Parasitol Vector Borne Dis) - "Haemonchus contortus and Trichostrongylus colubriformis were the main contributors to the resistance, whereas Trichostrongylus axei and Oesophagostomum columbianum remained highly susceptible to eprinomectin and albendazole. These findings demonstrate the value of integrating FECRT with nemabiome to provide species-level insights into treatment responses, supporting the development of targeted deworming protocols and improving anthelmintic resistance surveillance in regions with limited treatment options."

Journal

Assessment of the efficacy and safety of two albendazole regimens for the treatment of hypermicrofilaraemic loiasis in adults in Woleu-Ntem Province, Gabon: A phase IIb single-blind randomised controlled trial. (PubMed, PLoS Negl Trop Dis) - "Daily administration of 400 mg albendazole for 30 days effectively reduces microfilarial loads in patients with L. loa hypermicrofilaraemia and is well tolerated and safe. This pre-treatment regimen may reduce the risk of adverse events associated with ivermectin administration. Further research is needed to evaluate the long-term persistence of microfilarial suppression."

Clinical • Journal • P2b data • Infectious Disease

Giant cystic choroid plexus papilloma mimicking intracerebral hydatid cyst. (PubMed, Childs Nerv Syst) - "It is imperative to consider hydatid cysts as a cause of giant intra-axial cysts given the disastrous consequences of anaphylactic shock if spillage occurs and this differential has not been considered. This is a rare case of an entirely cystic choroid plexus papilloma mimicking a hydatid cyst."

Journal • Oncology