albendazole / Generic mfg. - LARVOL DELTA

The Puncture, Aspiration, Injection and Re-aspiration (PAIR) Technique of Hepatic Hydatid Cyst: A Case Report and Review of Literature. (PubMed, Cureus) - "Our report demonstrates that percutaneous drainage with adjunctive albendazole therapy is a feasible and effective alternative to surgery in hemodynamically stable patients with ruptured hepatic hydatid cysts. Further studies are warranted to refine patient selection criteria and optimize long-term outcomes."

Journal • Gastrointestinal Disorder • Infectious Disease • Pain

Residual and recurrent spinal echinococcosis: MRI and intraoperative correlation in two patients. (PubMed, BMJ Case Rep) - "Both cases were treated with albendazole (15 mg/kg/day). We highlight the classical imaging features on MRI and CT, surgical observations and the importance of vigilant follow-up. Early diagnosis and multimodal management are crucial in preventing irreversible neurological deficits."

Journal • Musculoskeletal Diseases • Orthopedics

Etidronate May Reduce Residual Calcification in Porcine Neurocysticercosis. (PubMed, Am J Trop Med Hyg) - "All animals received albendazole plus praziquantel for 5 days, either alone (n = 6) or with etidronate (20 mg/kg/day for 2 weeks, then 10 mg/kg/day for 8 weeks; n = 6). Etidronate reduced the risk of calcification by 21% (risk ratio = 0.79; 95% CI: 0.65-0.90; P = 0.020); however, there was considerable individual variability in the magnitude of this risk reduction, as well as significantly decreased calcium and phosphorus content in granulomas. Etidronate was well tolerated and may serve as an adjunctive therapy to reduce residual calcification after antiparasitic treatment in NCC."

Journal • Preclinical • CNS Disorders • Epilepsy • Inflammation

Effect of apatinib on albendazole metabolism in vitro and in vivo. (PubMed, Bioorg Chem) - "For the metabolites albendazole sulfoxide and hydroxyalbendazole, apatinib caused significant increases in AUC(0-t), AUC(0-∞), and Tmax, while a significant decrease in CLz/F. In summary, apatinib could inhibit the metabolism of albendazole in vitro and in vivo, so albendazole should be closely monitored for adverse effects when used in combination with apatinib and discontinued if necessary."

Journal • Preclinical • Oncology • CYP3A4

Detecting Angiostrongylus cantonensis Eosinophilic Meningitis with Highly Sensitive Quantitative Polymerase Chain Reaction-Report of Five Cases in Southern India. (PubMed, Am J Trop Med Hyg) - "All patients responded to management with steroids and albendazole. When AEM cases reported from India were reviewed and mapped, the majority were reported from southern Indian states. Managing and preventing this emerging zoonosis in these areas requires 1) access to accurate and timely diagnostics, 2) increasing awareness among clinicians, and 3) risk assessment with public health officials on acquiring infections from water and food contaminated by gastropods and other paratenic hosts."

Journal • Polymerase Chain Reaction • CNS Disorders • Infectious Disease • Ocular Infections • Ophthalmology

Trichinellosis after Raw Bear Eyeball Consumption. (PubMed, Am J Trop Med Hyg) - "Serology confirmed trichinellosis, and treatment with albendazole led to full recovery...Clinicians and public health practitioners should be aware that any uncooked tissue may carry an infection risk. These findings underscore the need for vigilance against unconventional transmission routes and culturally sensitive education for accurate diagnosis and prevention."

Journal • Fatigue • Infectious Disease • Musculoskeletal Pain • Pain

Short-Term Consequences of Incomplete Resection of an Echinococcal Cyst of the Lung. (PubMed, Am J Trop Med Hyg) - "Postoperative histology confirmed residual echinococcal tissue. The patient was discharged on prolonged albendazole therapy and remains under follow-up."

Journal • Pain

Characterisation of Trichuris incognita n sp in Côte d'Ivoire: a morphological, genomic, and genome-wide association with drug sensitivity study. (PubMed, Lancet Microbe) - "Our results demonstrate that trichuriasis can be caused by multiple whipworm species, and that differences in response rates might result from species responding differently to drug treatment, rather than from the intraspecies establishment of resistance. This discovery, coupled with the high tolerability of T incognita n sp to albendazole-ivermectin, marks a substantial shift in how we understand and approach whipworm infections."

Journal • Infectious Disease

Albendazole-doxycycline combination therapy alleviates MRI- and pathology-evident neuroinflammation and restores IL-33/GFAP balance in mouse neuroangiostrongyliasis. (PubMed, Parasit Vectors) - "ABZ-DOX co-therapy was associated with reduced parasite recovery and multilevel improvements across pathology, MRI, and glial markers in mice neuroangiostrongyliasis. These findings support ABZ-DOX co-therapy as a candidate regimen for further investigation in the management of A. cantonensis-associated neuroinflammation."

Journal • Preclinical • CNS Disorders • Hematological Disorders • Infectious Disease • Inflammation • FAP • GFAP • IL33

Effectiveness of single-dose albendazole against soil-transmitted helminth infection in children: A longitudinal study in a tribal dominated district of Odisha, India. (PubMed, Indian J Med Res) - "Integrating treatment with WASH (Water, Sanitation, and Hygiene) programs and health education may improve long-term control. Monitoring resistance patterns and exploring combination therapies could further enhance treatment efficacy."

Journal • Observational data • Infectious Disease

Cardiac Hydatid Cyst: A Diagnostic and Therapeutic Challenge Requiring a Multidisciplinary Approach. (PubMed, JACC Case Rep) - "Cardiac hydatid cysts, although exceptional, should be suspected in patients from endemic regions presenting with intracardiac masses. Negative serologic results do not exclude the diagnosis. Echocardiography and cardiac magnetic resonance imaging are key for diagnosis and surgical planning. Long-term follow-up is mandatory because of the risk of recurrence, even after complete resection."

Journal • Pain • Pulmonary Disease

Toxocariasis in Internationally Adopted Children: Seroprevalence, Diagnostic and Therapeutic Strategies: Toxocariasis in Internationally Adopted Children. (PubMed, Int J Infect Dis) - "Approximately one in six internationally adopted children shows Toxocara spp. seropositivity. While IgG-TES ELISA is a sensitive screening tool, confirmatory Western blot substantially improves specificity and diagnostic stewardship, reducing unnecessary second-level investigations. A substantial proportion of seropositive children likely represent clinically inactive seropositivity, for which it is not possible to differentiate recent infection from past exposure to the parasite. Integrating serology with eosinophil counts, IgE levels, and clinical assessment is crucial to distinguish active from resolved infection and to identify children who require clinical and instrumental follow-up and albendazole therapy, thereby avoiding unnecessary interventions."

Journal • Eosinophilia • Infectious Disease

Insights from a fatal case of disseminated albendazole refractory Annacaliia algerae myositis (ESCMID Global 2026) - No abstract available

Clinical • Immunology • Myositis

Albendazole pharmacokinetics in plasma and cystic tissue of human cystic and alveolar echinococcosis (ESCMID Global 2026) - No abstract available

PK/PD data

The Death to Onchocerciasis and Lymphatic Filariasis (DOLF) project: Accomplishments and ongoing research. (PubMed, PLoS Negl Trop Dis) - "More recently, we have shown that single-dose treatment with moxidectin plus albendazole is superior to the ivermectin plus albendazole regimen currently recommended for LF elimination in Africa. DOLF has also addressed the issue of MDA compliance, because improved treatments cannot be effective if people do not swallow the tablets. We highlight here some of DOLF's important discoveries that support the control and elimination of neglected tropical diseases caused by helminths."

Journal • Review • Infectious Disease • Ophthalmology

Poor Response to Albendazole in Hookworm-Infected Abnormal Haemoglobin Carriers. (PubMed, Trop Med Int Health) - "These findings suggest that abnormal haemoglobin may be a host factor contributing to low albendazole efficacy in treating hookworm infections."

Journal • Infectious Disease

Cystic echinococcosis in patients with leukemia: Clinical challenges and review of reported cases. (PubMed, IJID Reg) - "One patient had chronic lymphocytic leukemia and a hepatic CE2 cyst managed with albendazole and surgery before chemoimmunotherapy, and another patient had B-cell acute lymphoblastic leukemia and prior hepatic and pulmonary CE treated with concurrent albendazole and induction chemotherapy...A literature review identified only a few cases, mostly acute myeloid leukemia, and none from Latin America. These cases highlight therapeutic dilemmas in balancing infection control and malignancy treatment, underscoring the need for tailored management strategies in endemic regions."

Journal • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • B Acute Lymphoblastic Leukemia • Chronic Lymphocytic Leukemia • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Oncology

Potential of secondary metabolite compounds of sweet potato (Ipomoea batatas) leaves as anthelmintic against Haemonchus contortus. (PubMed, Open Vet J) - "was almost as effective as 2 mg/ml albendazole after 3 hours and equal after 4 hours...exhibited anthelmintic effects against H. contortus. Ultrastructural changes were observed on the rough, wrinkled surface with irregular cuticle structure and the occurrence of damage, indicating that the anterior and posterior cuticle structures were vulnerable."

Journal

Hepatic cystic echinococcosis in a low-endemic region, Denmark. (PubMed, IDCases) - "The patient was commenced on albendazole and underwent a minimal invasive percutaneous procedure. Repeated CT images months later detected decreased size of the lesions without evidence of recurrence. This case highlights the importance of considering E. granulosus as a differential diagnosis in cystic liver lesions, even in patients without obvious exposure."

Journal • Anorexia • Fatigue • Hepatology • Infectious Disease • Oncology • Pain

Point-of-Care Ultrasound Identification of Motile Enterobius vermicularis in the Appendix of a Toddler: The Youngest Reported Case and Successful Nonoperative Management of Early Appendicitis. (PubMed, Pediatr Emerg Care) - "True intraluminal motility is a critical sonographic discriminator of parasitic infestation and can fundamentally alter management decisions. In this case, early identification of E. vermicularis supported a safe, nonoperative strategy for early appendicitis. Incorporating POCUS early in the evaluation of atypical pediatric abdominal pain may prevent unnecessary surgical intervention."

Journal • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Pain • Pediatrics

Research Project on the Prevention and Control of Clonorchiasis (Subproject 1: Comparative Study on the Therapeutic Efficacy of Anthelmintic Drugs against Clonorchiasis) (ChiCTR) - P4 | N=567 | Recruiting | Sponsor: The People’s Hospital of Guangxi Zhuang Autonomous Region; The People’s Hospital of Guangxi Zhuang Autonomous Region

New P4 trial

Multicenter Cross-Sectional Study on Pharmacotherapeutic Regimens for Clonorchiasis in Guangxi: Focus on Clinical Application Status of Albendazole and Praziquantel (ChiCTR) - P=N/A | N=650 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Guangxi Medical University; The First Affiliated Hospital of Guangxi Medical University

New trial

Thereaputic efficacy of single dose Albendazole against Ascaris lumbricoides, prevalence of re-infection, and its associated factors among school children at Northwest Ethiopia: an open-label trial study. (PubMed, BMC Infect Dis) - No abstract available

Journal • Infectious Disease

Moxidectin for LF, Cote d'Ivoire (DOLF) (clinicaltrials.gov) - P3 | N=164 | Completed | Sponsor: Washington University School of Medicine | Active, not recruiting ➔ Completed

Trial completion

Coacervated and Freeze-Dried Polysaccharides-Nanoparticle with Efficient Encapsulation of Albendazole for High-Performance Treatment of Monogenean Parasite Infestation in Tilapia Fish. (PubMed, Int J Mol Sci) - "The treatment of 100% prevalence of monogeneans was effective with a six-day dosage providing a total of 915 mg/kg b.w. of drug, resulting in total parasite clearance after 10 days from the treatment beginning, evidenced by microscopy analysis, and no mortality occurred. Therefore, molecular interactions between biofriendly polyelectrolytes yielded albendazole-carrying nanoparticles for high-efficiency parasite treatment in fish farming."

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