atenolol / Generic mfg. - LARVOL DELTA

Blocking β-adrenergic receptor signaling enhances the sensitivity of AML to MCL-1 inhibitor S63845. (PubMed, Life Sci) - "Stress induced catecholamines confer S63845 resistance in AML through β-AR signaling. Critically, β2-AR blockade by propranolol downregulates MCL-1 expression, potentiating S63845 sensitivity in vitro and in vivo. Our findings establish pharmacological β-AR blockade as a promising strategy to overcome resistance in MCL-1-targeted therapy by abrogating compensatory MCL-1 upregulation."

IO biomarker • Journal • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Oncology • BCL2

First-Line β-Blocker Use for Hypertension in the Veterans Health Administration. (PubMed, JAMA Netw Open) - "Metoprolol and carvedilol were the most commonly initiated β-blockers and increased over time, and atenolol initiation decreased over time. In this cross-sectional study, most veterans using β-blockers as a first-line treatment for hypertension did not have compelling indications, and several factors were associated with likelihood of β-blocker initiation in this group. Interventions are needed to improve initial guideline-concordant treatment for veterans with incident hypertension."

Journal • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Hepatology • Hypertension • Immunology • Myocardial Infarction

Phototrophic periphyton tolerance reflects in situ exposure to pharmaceuticals overtime - A translocation study using a pollution-induced community approach (PICT). (PubMed, J Hazard Mater) - "Acute toxicity tests on photosynthesis were performed to assess the evolution of community tolerance to three pharmaceuticals (atenolol, diclofenac, paracetamol), using a pollution-induced community tolerance (PICT) approach...It suggests that changes in tolerance, reflecting community adaptation or resilience, were at least partly related to changes in diatom assemblages. Combining PICT with DNA metabarcoding is a relevant strategy for in situ assessment of the effects of pharmaceuticals on aquatic microbial communities."

Journal

Application of Lactation Physiologically Based Pharmacokinetic Modeling to Predict Milk Exposure of Passively Diffused Drugs. (PubMed, J Clin Pharmacol) - "As a part of the framework, the current paper focuses on performance of lactation PBPK models to predict maternal plasma and milk concentrations for drugs that are not substrates of P-glycoprotein (P-gp) or breast cancer resistance protein (BCRP) transporters-atenolol, escitalopram, and alprazolam. The current work shows the potential of lactation PBPK models to predict drug exposure in human milk for drugs that are not P-gp or BCRP substrates. The approach will be further evaluated for drugs that are substrates for these active transporters known to be present in mammary tissues."

Journal • PK/PD data • Breast Cancer • Oncology • Solid Tumor

Prolonged operating cycle and enhanced removal of emerging contaminants in slow sand filters: Significance of algae-bacteria interaction. (PubMed, J Hazard Mater) - "These BioMnOx significantly improved the removal efficiencies of carbamazepine (CMZ), diclofenac (DCF), atenolol (ATL), sulfamethoxazole (SMX), and ofloxacin (OFL). Furthermore, the algae-bacteria columns exhibited a 58 % longer operational cycle due to MOB's inhibition of algal growth, which reduced head loss by mitigating algal-bloom-related clogging. These findings highlight the potential of algae-bacteria interactions to enhance SSF performance in removing ECs and sustaining efficient filter operation."

Journal

Forward osmosis followed by reverse osmosis for the removal of contaminants of emerging concern using a CO2-responsive draw agent (ACS-Fall 2025) - "The CECs investigated were ciprofloxacin, atenolol, trimethoprim, sulfamethoxazole, acetaminophen, and carbamazepine. Using a CO2-responsive draw agent resulted in high CEC removal efficiencies over multiple filtration cycles."

RaP-AF: Rate Control in Patients With Atrial Fibrillation (clinicaltrials.gov) - P=N/A | N=50 | Active, not recruiting | Sponsor: National Taiwan University Hospital | Not yet recruiting ➔ Active, not recruiting | Trial completion date: Jun 2022 ➔ Dec 2026

Enrollment closed • Trial completion date • Atrial Fibrillation • Cardiovascular

Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries (clinicaltrials.gov) - P4 | N=60 | Recruiting | Sponsor: Damanhour Teaching Hospital | Trial completion date: Jul 2025 ➔ Jan 2026 | Trial primary completion date: Jul 2025 ➔ Jan 2026

Trial completion date • Trial primary completion date • Anesthesia • Hypotension • Otorhinolaryngology

The potential of native microalgae consortia to remove pharmaceutical compounds present in treated wastewater. (PubMed, J Environ Manage) - "The removal efficiency of these compounds by native microalgae consortia was variable, ranging from almost no removal for Clofibric acid or Ketoprofen to near complete removal for Fluoxetine, Venlafaxine, Atenolol or Diuron. In addition to what is now reported, microalgae treatment also removes other pollutants, such as nutrients, metals or microplastic particles, constituting a versatile tertiary treatment for polishing treated wastewaters. These findings demonstrate the potential of native microalgae consortia-based systems to improve wastewater treatment processes, mitigating the environmental impact of pharmaceutical compounds while producing potentially useful biomass."

Journal • Pain

Efficient removal of beta-blockers from water using fluorinated covalent organic polymers: Insights into sigmoidal adsorption behavior and environmental applications. (PubMed, Environ Res) - "In this research, fluorinated covalent organic polymer (FCOP) was synthesized and evaluated as a novel adsorbent for removing atenolol (ATL) and metoprolol (MTL), two widely prescribed beta-blockers frequently found in water environments...Furthermore, FCOP maintained high efficiency even in complex aqueous environments containing inorganic ions, humic acids, and in real water from the river and sewage treatment plants (STP), underscoring its practical applicability. Given its straightforward one-pot synthesis, cost-effectiveness, and excellent adsorption capabilities, FCOP represents a promising solution for addressing pharmaceutical pollution, providing critical insights into advanced materials for sustainable water purification technologies."

Journal

A Case of Thiazide-Induced Hyponatremia in an Elderly Patient. (PubMed, Cureus) - "She was previously taking famotidine, atorvastatin, losartan, triamterene, and atenolol to manage her hypertension and hyperlipidemia. Her medication was changed to azilsartan-chlorthalidone, amlodipine, and carvedilol one week before presentation for better management of her blood pressure...She was followed for two weeks and had been doing well. This case highlights the importance of taking a detailed history and examination, and taking into account drugs as a source of hyponatremia in elderly patients."

Journal • Cardiovascular • Dyslipidemia • Heart Failure • Hypertension

An integrated meta-omics approach for identifying candidate organic micropollutant degraders in complex microbial communities. (PubMed, Water Res) - "To demonstrate the approach, we used five nitrifier-rich batch cultures, first validating with ammonia (a macropollutant) before applying it to atenolol (an OMP)...By contrast, it was correlated with the expression of the amidohydrolase asparagine synthase (AsnB) identified in the Terrimonas and Flavobacterium MAGs. In summary, we present a novel association-based method for investigating biotransformation processes robust to variability in enzyme reaction kinetics with implications for OMP control."

Journal

β-blockers and risk of neuropsychiatric adverse events: An active-comparator restricted disproportionality on the FAERS. (PubMed, J Psychopharmacol) - "β-blockers, especially propranolol, may be associated with a higher risk of neuropsychiatric AEs compared to lisinopril and losartan. These findings highlight the importance of considering the specific β-blocker prescribed, particularly in patients at risk for central nervous system side effects. Further population-based studies are warranted to confirm these results."

Adverse events • Journal • Cardiovascular • CNS Disorders • Insomnia • Mental Retardation • Psychiatry • Sleep Disorder

Human pharmaceuticals surface water pollution across urban gradients in the Buenos Aires Metropolitan Region, Argentina. (PubMed, Environ Toxicol Chem) - "Owing to their average annual concentrations and frequencies, acetaminophen, ibuprofen, carbamazepine, atenolol, enalapril, metformin, and sildenafil were the dominant HAPIs. Shifts in HAPIs frequencies and concentrations around the overall medians were a better indicator of seasonal variations than the absolute values affected by hydrological conditions. This study enhances understanding of the relationship between urbanization and HAPIs surface water pollution in a major metropolitan area of South America, offering valuable data for future HAPIs aquatic ecological risk assessments in the region."

Journal

Thyroiditis After Botox Injection to the Neck: A Case of Thyrotoxicosis Triggered by Aesthetic Treatment (ENDO 2025) - "She was prescribed NSAIDs and atenolol, and started on a 5-week tapering course of prednisone, leading to resolution of symptoms and normalization of thyroid tests. Subacute thyroiditis can be due to radiation, trauma, or infections; this case describes a rare instance of subacute thyroiditis following Botox injection into the platysmal bands...found that eyelid injections of Botox on a Hashimoto patient caused persistent TSH elevation despite adequate levothyroxine therapy, likely due to anti-Botox antibodies inducing anti-TSH-R antibodies inhibiting TSH-R signaling... Botox injections to the cervical area used for both aesthetic and medical purposes are generally considered benign, however, can rarely trigger a severe thyroiditis reaction. Patients should be informed of said risk and monitor for possible symptoms of thyrotoxicosis. Early recognition of subacute thyroiditis allows for prompt diagnosis and appropriate management."

Clinical • Aesthetic Medicine • Endocrine Disorders • Immunology • Infectious Disease • Inflammation • Mood Disorders • Movement Disorders • Solid Tumor

From Hashimoto's Thyroiditis to Graves' Disease: Autoimmune Thyroid Disease, a Dynamic Spectrum (ENDO 2025) - "After the initial diagnosis of hypothyroidism, the patient remained on levothyroxine for around 8 years...The patient was started on Methimazole for the treatment of GD and Atenolol for symptomatic management which helped improve symptoms...The patient was seen by an Oculoplastic specialist who started the patient on Teprotumumab for the treatment of severe thyroid eye disease... Autoimmune thyroid disorder is a spectrum with its dynamic nature stemming from the delicate balance of different characteristic antibodies. This case is a cardinal reminder of this, and it documents the rare but possible phenomenon of transitioning from a diagnosis of HT to GD. Furthermore, it underscores the importance of the close monitoring of thyroid studies and antibody profiles in patients with an autoimmune thyroid disease."

Endocrine Disorders • Grave’s Disease • Immunology • Ophthalmology • Thyroid Eye Disease

An Unusual Case of Catecholamine-Secreting Carotid Body Paraganglioma (ENDO 2025) - "She was started on doxazosin 2 mg and atenolol 25 mg oral daily for symptom control. HNPGLs are rarely associated with catecholamine hypersecretion. The prevalence of clinically significant catecholamine secreting HNPGLs has been estimated to be 7.7%-9.2%. However, this patient has bilateral carotid body PGLs with distinct metabolic activity."

Clinical • Cough • Endocrine Cancer • Endocrine Disorders • Gastrointestinal Disorder • Metabolic Disorders • Musculoskeletal Pain • Neuroendocrine Tumor • Oncology • Otorhinolaryngology • Pain • Respiratory Diseases • Solid Tumor • SYP

Elevated Risk of Life Threatening Metabolic Acidosis with Combined Metformin and SGLT2 Inhibitor Therapy in the Elderly (ENDO 2025) - "Her home medications included Dapagliflozin 5 mg (started 6 months ago), Metformin XR 500 mg BID (started 8 years ago), Amlodipine, Atenolol, Hydrochlorothiazide, Olmesartan, and Rosuvastatin. Although it is often challenging to identify the exact cause of lactic acidosis, her clinical picture raised suspicion of metformin-induced lactic acidosis due to the initial failure to respond to fluid resuscitation and pressors, followed by improvement after CRRT, and a negative work-up for infection and other causes.There is a similar case presenting severe euglycemic ketoacidosis and lactic acidosis in a diabetic patient on chronic Dapagliflozin and Metformin therapy, which was triggered by poor oral intake and dehydration, ultimately requiring dialysis. Our case underscores the caution needed when using a combination of metformin and SGLT-2 inhibitors, especially in elderly T2D patients with decreased"

Clinical • Alzheimer's Disease • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Dementia • Diabetes • Diabetic Nephropathy • Hypotension • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

Graves' Disease and Thyrotoxic Periodic Paralysis: A Case Series (ENDO 2025) - "Following development of hypothyroidism, he was placed on levothyroxine replacement, with no further recurrence of paralysis.Case 2: An 18 y.o. Caucasian male with a history of Graves' disease presented after multiple hospitalizations for hypokalemia and lower extremity weakness...He was restarted on methimazole as well as atenolol and advised on medical adherence... These cases highlight the under recognition of TPP in non-Asian populations in the United States, leading to delayed diagnosis and recurrent hospitalizations. Clinicians should maintain a high index of suspicion for TPP in young males with hypokalemia, and generalized weakness, particularly in the setting of undiagnosed or untreated hyperthyroidism. Prompt recognition and definitive treatment of hyperthyroidism is critical to preventing recurrent episodes and associated morbidity."

Clinical • Endocrine Disorders • Grave’s Disease • Myositis

Paradigm Shift in the Management of Infantile Hemangiomas in the Beta-blocker Era: A Retrospective Cohort Study. (PubMed, J Am Acad Dermatol) - "At tertiary centers, treatment was initiated in a majority of patients. This represents an important shift in the management practices of IH, moving away from the traditional hands-off approach prior to the emergence of beta blockers for IH."

Journal • Retrospective data • Oncology • Pediatrics

In brief: Low-dose chlorthalidone (HemiClor) for hypertension. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Cardiovascular • Hypertension

Quantifying cross-linking strength in sodium starch glycolate and its impact on tablet disintegration and dissolution. (PubMed, Eur J Pharm Biopharm) - "The tablet disintegration and API dissolution of these SSG grades were evaluated for a wet granulation formulation with atenolol...The findings of this study show that understanding the type of cross-link and the SXL of SSG can support formulators with the development of good, robust formulations, in line with a quality-by-design approach. The provided case study shows that formulators can make their formulations more robust to stress exposure before, during or after tablet manufacturing by using an SSG grade with phosphorous cross-links, thereby limiting the risk of product failure."

Journal

3D-Printed Boron-Nitrogen Doped Carbon Electrodes for Sustainable Wastewater Treatment via MPECVD. (PubMed, Nanomicro Lett) - "Electrochemical characterization demonstrated that the optimized electrodes performed significantly better, achieving 4.7-, 4-, and 6.5-fold increases in the degradation rates of atenolol, metoprolol, and propranolol, respectively, during electrochemical oxidation. These results highlight the efficacy of the integrated fabrication and simulation approach in producing high-performance electrodes for sustainable wastewater treatment applications."

Journal

Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids. (PubMed, Transl Psychiatry) - "Notably, one of the genes in identified loci (RRP1B) was found to be a target of the approved drug Atenolol suggesting potential for drug repurposing. Overall, our findings suggest that taking interaction between genetic variants and psychosocial factors into account and including genetically diverse populations can lead to novel discoveries for serum lipids."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Exploring the relationship between atenolol use and depression: A network pharmacology approach using NHANES data. (PubMed, J Affect Disord) - "Our findings indicate a positive correlation between atenolol use and depression, particularly among individuals in the middle-aged demographic. It is important to monitor the mental health of patients when prescribing atenolol."

Journal • Cardiovascular • CNS Disorders • Depression • Mood Disorders • Psychiatry • ADRB2 • DRD2 • SLC6A3